10 research outputs found
A Multilab Replication of the Ego Depletion Effect
Get PDFThere is an active debate regarding whether the ego depletion effect is real. A recent preregistered experiment with the Stroop task as the depleting task and the antisaccade task as the outcome task found a medium-level effect size. In the current research, we conducted a preregistered multilab replication of that experiment. Data from 12 labs across the globe (N = 1,775) revealed a small and significant ego depletion effect, d = 0.10. After excluding participants who might have responded randomly during the outcome task, the effect size increased to d = 0.16. By adding an informative, unbiased data point to the literature, our findings contribute to clarifying the existence, size, and generality of ego depletion
The interplay between explicit and implicit right-wing populism in Germany and Switzerland
No full textDiscrepancies between Implicit and Explicit Self–concepts of Intelligence Predict Performance on Tests of Intelligence
No full textMonitoring of mononuclear cell subsets isolated from the coronary sinus and the right atrium in patients after heart allograft transplantation
No full textOn the Road to the Unconscious Self: Understanding when People Gain Self–knowledge of Implicit Disgust Sensitivity from Behavioural Cues
No full textHow Implicit–Explicit Consistency of the Intelligence Self–Concept Moderates Reactions to Performance Feedback
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A Multilab Replication of the Ego Depletion Effect
No full text10.1177/1948550619887702SOCIAL PSYCHOLOGICAL AND PERSONALITY SCIENCE12114-2
Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses
Get PDFSummaryBecause immune responses simultaneously defend and injure the host, the immune system must be finely regulated to ensure the host’s survival. Here, we have shown that when injected with high Toll-like receptor ligand doses or infected with lymphocytic choriomeningitis virus (LCMV) clone 13, which has a high viral turnover, inflammatory monocyte-derived dendritic cells (Mo-DCs) engulfed apoptotic erythroid cells. In this process, called hemophagocytosis, phosphatidylserine (PS) served as an “eat-me” signal. Type I interferons were necessary for both PS exposure on erythroid cells and the expression of PS receptors in the Mo-DCs. Importantly, hemophagocytosis was required for interleukin-10 (IL-10) production from Mo-DCs. Blocking hemophagocytosis or Mo-DC-derived IL-10 significantly increased cytotoxic T cell lymphocyte activity, tissue damage, and mortality in virus-infected hosts, suggesting that hemophagocytosis moderates immune responses to ensure the host’s survival in vivo. This sheds light on the physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases
