Metody fizykalne w terapii odleżyn = Physical methods for the treatment of bedsores

Radzimińska Agnieszka, Stettler Dorota, Weber-Rajek Magdalena, Zimmermann Agnieszka Anna, Sowała Krzysztof, Goch Aleksander, Zukow Walery. Metody fizykalne w terapii odleżyn = Physical methods for the treatment of bedsores. Journal of Education, Health and Sport. 2015;5(4):405-414. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.38244http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A405-414https://pbn.nauka.gov.pl/works/685685Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.03.2015. Revised 05.04.2015. Accepted: 26.04.2015. Metody fizykalne w terapii odleżynPhysical methods for the treatment of bedsores Agnieszka Radzimińska1, Dorota Stettler2, Magdalena Weber-Rajek1, Agnieszka Anna Zimmermann3, Krzysztof Sowała4, Aleksander Goch1, Walery Zukow5 1.      Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra Fizjoterapii, Bydgoszcz, Polska2.      Bydgoska Szkoła Wyższa, Bydgoszcz, Polska3.      Wyższa Szkoła Gospodarki, Bydgoszcz, Polska4.      Szpital Polski, Sztum, Polska5.      Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bydgoszcz, Polska Adres do korespondencji:dr n. med. Agnieszka RadzimińskaUniwersytet Mikołaja Kopernika w ToruniuCollegium Medicum im. Ludwika Rydygiera w BydgoszczyKatedra Fizjoterapiiul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcze-mail: [email protected] StreszczenieOdleżyny (obok zakażeń szpitalnych) to najpoważniejsze powikłania występujące u pacjentów hospitalizowanych. Od lat poszukuje się najskuteczniejszych metod leczenia zachowawczego odleżyn. Wśród tych metod należy zwrócić uwagę na metody leczenia fizykalnego, a wśród nich: fototerapię, elektroterapię, magnetoterapię i sonoterapię.  SummaryPressure ulcers (next to nosocomial infections) are the most serious complications occurring in hospitalized patients. For years he sought the most effective methods of conservative treatment of pressure ulcers. Among these methods, you must pay attention to the methods of physical treatment, among them: phototherapy, electrotherapy, magnetic fields and sonotherapy. Słowa kluczowe: metody fizykalne; terapia; odleżyny.Keywords: physical methods; therapy; bedsores

Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review

Radzimińska Agnieszka, Zimmermann Agnieszka Anna, Weber-Rajek Magdalena, Strojek Katarzyna, Bułatowicz Irena, Goch Aleksander, Zukow Walery. Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review. Journal of Education, Health and Sport. 2015;5(10):108-120. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.32518http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2810%29%3A108-120https://pbn.nauka.gov.pl/works/660102Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.08.2015. Revised 05.09.2015. Accepted: 20.10.2015. Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literaturySterile necrosis of bone, the characteristics of the illness and physical examination - a literature reviewAgnieszka Radzimińska1, Agnieszka Anna Zimmermann2, Magdalena Weber-Rajek1, Katarzyna Strojek1, Irena Bułatowicz1, Aleksander Goch1, Walery Zukow31.      Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum w Bydgoszczy, Katedra Fizjoterapii, Bydgoszcz, Polska2.      Wyższa Szkoła Gospodarki, Bydgoszcz, Polska3.      Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bydgoszcz, Polska StreszczenieJałowe martwice kości stanowią zespół chorobowy cechujący się obumieraniem tkanki kostnej oraz tkanki chrzęstnej bez udziału chorobotwórczych drobnoustrojów. Schorzenie to występuje często w nasadach rosnących kości dzieci i młodzieży i jest konsekwencją braku połączeń pomiędzy naczyniami nasad i przynasad kości (brak krążenia obocznego) w okresie wzrostu. Do najczęstszych postaci tej choroby zaliczamy: chorobę Perthesa (martwica typu Legga-Calvégo-Perthesa), chorobę Osgooda-Schlattera, chorobę Freiberga-Köhlera II, chorobę Köhlera I, chorobę Haglunda, chorobę Scheuermanna. Etiologia choroby nie jest znana. Celem niniejszej pracy jest przegląd literatury dotyczącej charakterystyki poszczególnych postaci jałowych martwic kości oraz postępowania fizykalnego w różnych postaciach tej choroby. Abstract Avascular necrosis constitute a syndrome characterized by the withering away of bone tissue and cartilaginous tissue without the participation of pathogenic microorganisms. This disease often occurs in the roots of the growing bones of children and young people and is a consequence of the lack of connection between vessels and the metaphyseal bone epiphysis (lack of collateral circulation) during growth. The most common form of the disease include: Perthes disease (Legg-Calve-Perthes disease), Osgood-Schlatter disease, Freiberg-Köhler disease II, Köhler disease I, Haglund's disease, Scheuermann's disease. The etiology of the disease is not known. The aim of this article is review the literature on the characteristics of each form of aseptic osteonecrosis and physiotherapy in various forms of the disease. Słowa kluczowe: jałowe martwice kości, postępowanie fizykalne.Key word: sterile necrosis of bone, physical examination

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation