When Does Changing Representation Improve Problem-Solving Performance?

The aim of changing representation is the improvement of problem-solving efficiency. For the most widely studied family of methods of change of representation it is shown that the value of a single parameter, called the expulsion factor, is critical in determining (1) whether the change of representation will improve or degrade problem-solving efficiency and (2) whether the solutions produced using the change of representation will or will not be exponentially longer than the shortest solution. A method of computing the expansion factor for a given change of representation is sketched in general and described in detail for homomorphic changes of representation. The results are illustrated with homomorphic decompositions of the Towers of Hanoi problem

Cellular immune response to acute exercise

Objectives: Exercise‐induced cellular mobilization might play a role in treatment and prevention of several diseases. However, little is known about the impact of different exercise modalities on immune cell mobilization and clinical cellular inflammation markers. Therefore, the present study aimed to investigate differences between acute endurance exercise (EE) and resistance exercise (RE) on cellular immune alterations. Methods: Twenty‐four healthy men conducted an acute EE (cycling at 60% of peak power output) and RE (five exercise machines at 70% of the one‐repetition maximum) session lasting 50 minutes in randomized order. Blood samples were collected before, after and one hour after exercise cessation. Outcomes included counts and proportions of leukocytes, neutrophils (NEUT), lymphocytes (LYM), LYM subsets, CD4/CD8 ratio, and the clinical cellular inflammation markers NEUT/LYM ratio (NLR), platelets/LYM ratio (PLR), and systemic immune inflammation index (SII). Results: Alterations in all outcomes were revealed except for CD8+ T cells, CD4/CD8 ratio, NLR, and PLR. EE induced a stronger cellular immune response and provoked alterations in more immune cell populations than RE. SII was altered only after EE. Conclusion: An acute EE session causes a stronger mobilization of immune cells than RE. Additionally, SII represents an integrative marker to depict immunological alterations

Noise and performance of propellers for light aircraft : final report

July 1980Project Manager: G. P. Succi ; Contributors: E.E. Larrabee, P.D. [i.e. P. B.] Dunbeck, D.H. Munro, J.A. Zimmer; Principal Investigators: K.U. Ingard, J.L. KerrebrockIncludes bibliographical references (pages 22-23)Final report. February 24, 1978 to July 31, 1980Introduction and Summary: The project "Noise and Performance of Propellers for Light Aircraft," Contract #NASl-15154 between NASA Langley and MIT, has now been completed, and the main results obtained are summarized in this report and its appendices. The primary practical objective of the study was to explore the possibility of reducing the noise from a general aviation type propeller without altering significantly its aerodynamic performance or the engine characteristics. After an extensive study of this question, involving aerodynamic and acoustic theory, design, construction and wind tunnel testing of model propellers, design and manufacturing of full scale propellers and, finally, flight tests, we are pleased to report that for one of the propellers tested an overall reduction of 4.8 dBA as measured in a flight test was achieved.The theory deals with aerodynamics and acoustics of lightly loaded propellers with subsonic tip speeds and includes studies of the effects of sweeping the blades, altering the radial load distribution, and changing the number of blades. These studies lead to new insight into the general problem of sound generation from moving bodies. Of particular value are the algorithms, which are well suited for computer coding. The wind tunnel tests involved three propellers, 1/4 scale, including a replica of a fixed pitch propeller used on a 150 HP single engine airplane. The other two propellers were designed to have the peak radial load distribution shifted inboard. The acoustic wind tunnel which was used in these tests enabled measurement not only of the radiated sound field but also the thrust and torque of the propeller. In addition, the load distribution was determined indirectly from wake surveys.Sound pressure signatures were obtained at different locations and speeds (up to a tip Mach number of 0.75) and compared with theoretical predictions in which only the shape and motion of the propeller were needed as input parameters; no empirical adjustments were made. Agreement to within a few percent was obtained throughout except in the presence of a transonic "buzz" instability which was encountered within a narrow speed range. On the basis of the theoretical analysis and its verification in the model tests, a two-bladed fixed pitch propeller was designed for a 150 HP single engine airplane. Flight tests with this propeller indicated about the same performance as the production propeller for that airplane, but the maximum sound level during a full power flyover at 1000 feet was found to be 4.8 dBA lower. A second propeller, with three blades and fixed pitch, was designed for the Ohio State University 180 HP single engine airplane.Flight tests of this propeller have not yet been made at this time.NASA Contract NAS1-1515

CULTIVO DE PLEUROTUS OSTREATUS EM RESIDUOS DA AGROINDUSTRIA DE MILHO

Este trabalho avaliou o potencial do fungo Pleurotus ostreatus para a conversão de resíduos da cadeia do milho oriundos da região Sudoeste do Paraná. A metodologia do trabalho consistiu em estudar através de planejamento fatorial de experimentos completo o efeito dos co-substratos palha de milho e efluente agroindustrial oriundo do processo de produção de farinha de milho, canjica especial e farinha de biju. Os resultados mostraram que a adição do efluente nos níveis de variação estudados reduziu o grau de colonização do formulado pelo fungo. Os melhores resultados, que produziram o maior índice de colonização (93%) foi observada para a condição que utilizou 30% de palha de milho e 30% de efluente agroindustrial

Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis-a community-based randomized controlled trial

Background: The relevance of regular moderate to intense exercise for ameliorating psychomotor symptoms in persons with multiple sclerosis (pwMS) is becoming increasingly evident. Over the last two decades, emerging evidence from clinical studies and animal models indicate immune regulatory mechanisms in both periphery and the central nervous system that may underlie these beneficial effects. The integrity of the blood-brain barrier as the main structural interface between periphery and brain seems to play an important role in MS. Reducing the secretion of proteolytic matrix metalloproteinases (MMP), i.e. MMP-2, as disruptors of blood-brain barrier integrity could have profound implications for MS. Methods: In this two-Armed randomized controlled trial 64 participants with relapsing-remitting MS (RRMS) (EDSS 0-4.0) will be allocated to either an intervention group or a passive wait list control group. The intervention group will perform 60 min of combined functional resistance and endurance exercises 3x per week over a period of 12 weeks in a community-based and publicly available setting. Changes in serum concentration of MMP-2 will be the primary outcome. Secondary outcomes are numbers of immune cell subsets, soluble (anti-) inflammatory factors, physical capacity, cognitive performance, physical activity behavior, gait performance, and patient-reported outcomes. All outcome measures will be assessed at baseline and after week 12 with an additional blood sampling before, during and immediately after a single training session in week 6. Discussion: To our knowledge, this will be the first RCT to investigate both the acute and chronic effects of a community-based intense functional resistance and endurance exercise regimen in persons with RRMS. Combining analysis of biological and cognitive or psychological outcomes may provide a better understanding of the MS-specific symptomology. Trial registration: DRKS00017091; 05th of April, 2019; International Clinical Trials Registry Platform

Renormalization group and perfect operators for stochastic differential equations

We develop renormalization group methods for solving partial and stochastic differential equations on coarse meshes. Renormalization group transformations are used to calculate the precise effect of small scale dynamics on the dynamics at the mesh size. The fixed point of these transformations yields a perfect operator: an exact representation of physical observables on the mesh scale with minimal lattice artifacts. We apply the formalism to simple nonlinear models of critical dynamics, and show how the method leads to an improvement in the computational performance of Monte Carlo methods.Comment: 35 pages, 16 figure

The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction

Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it has shown conflicting results so far. This controversy may be associated with the glucocorticoid type and the period when it is administered. To elucidate these, the present aims to evaluate if the brief methylprednisolone acetate administration is determinant for heart adaptation after AMI. Male Wistar rats were divided into 3 groups: sham-operated (SHAM); infarcted (AMI); infarcted treated with methylprednisolone acetate (AMI+M). Immediately after surgery, the AMI+M group received a single dose of methylprednisolone acetate (40 mg/kg i.m.). After 56 days, the cardiac function was assessed and lungs, liver and heart were collected to determine rates of hypertrophy and congestion. Heart was used for oxidative stress and metalloproteinase activity analyses. Methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. Our data indicate that administration of methylprednisolone acetate shortly after AMI may be a therapeutic alternative for attenuation of detrimental ventricular remodeling

Genetical, clinical and functional analysis of a large international cohort of patients with autosomal recessive congenital ichthyosis due to mutations in NIPAL4

n/

Bright Field Microscopy as an Alternative to Whole Cell Fluorescence in Automated Analysis of Macrophage Images

Fluorescence microscopy is the standard tool for detection and analysis of cellular phenomena. This technique, however, has a number of drawbacks such as the limited number of available fluorescent channels in microscopes, overlapping excitation and emission spectra of the stains, and phototoxicity.We here present and validate a method to automatically detect cell population outlines directly from bright field images. By imaging samples with several focus levels forming a bright field -stack, and by measuring the intensity variations of this stack over the -dimension, we construct a new two dimensional projection image of increased contrast. With additional information for locations of each cell, such as stained nuclei, this bright field projection image can be used instead of whole cell fluorescence to locate borders of individual cells, separating touching cells, and enabling single cell analysis. Using the popular CellProfiler freeware cell image analysis software mainly targeted for fluorescence microscopy, we validate our method by automatically segmenting low contrast and rather complex shaped murine macrophage cells.The proposed approach frees up a fluorescence channel, which can be used for subcellular studies. It also facilitates cell shape measurement in experiments where whole cell fluorescent staining is either not available, or is dependent on a particular experimental condition. We show that whole cell area detection results using our projected bright field images match closely to the standard approach where cell areas are localized using fluorescence, and conclude that the high contrast bright field projection image can directly replace one fluorescent channel in whole cell quantification. Matlab code for calculating the projections can be downloaded from the supplementary site: http://sites.google.com/site/brightfieldorstaining