1,907 research outputs found

    Π’Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… Π·Π°Π΄Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΏΠΎΠ»ΡƒΠΏΡ€ΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΠΎΠΉ элСктроникС ΠΏΡ€ΠΈ ΠΏΠΎΠΌΠΎΡ‰ΠΈ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… сайтов сСти Π˜Π½Ρ‚Π΅Ρ€Π½Π΅Ρ‚

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    The report examines the author’s experience on the use of educational Internet sites by students in order to solve problems in the courses of semiconductor materials science and solid-state electronics. The pros and cons of the used websites are discussed, and the difficulties of the students work in an English-speaking environment are noted.Π’ Π΄ΠΎΠΊΠ»Π°Π΄Π΅ анализируСтся ΠΎΠΏΡ‹Ρ‚ Π°Π²Ρ‚ΠΎΡ€Π° обучСния студСнтов с использованиСм ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… сайтов Π˜Π½Ρ‚Π΅Ρ€Π½Π΅Ρ‚Π° ΠΏΡ€ΠΈ Ρ€Π΅ΡˆΠ΅Π½ΠΈΠΈ Π·Π°Π΄Π°Ρ‡ ΠΏΠΎ курсам ΠΏΠΎΠ»ΡƒΠΏΡ€ΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΠΎΠ³ΠΎ матСриаловСдСния ΠΈ Ρ‚Π²Π΅Ρ€Π΄ΠΎΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ элСктроники. Π Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ достоинства ΠΈ нСдостатки примСняСмых сайтов, ΠΎΡ‚ΠΌΠ΅Ρ‡Π°ΡŽΡ‚ΡΡ слоТности Ρ€Π°Π±ΠΎΡ‚Ρ‹ студСнтов Π² англоязычной срСдС

    Probation Institution in Russia

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    The author deals with the problems of taking under control the persons after a release from custody and rendering them help in social adaptation

    Two level anti-crossings high up in the single-particle energy spectrum of a quantum dot

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    We study the evolution with magnetic field of the single-particle energy levels high up in the energy spectrum of one dot as probed by the ground state of the adjacent dot in a weakly coupled vertical quantum dot molecule. We find that the observed spectrum is generally well accounted for by the calculated spectrum for a two-dimensional elliptical parabolic confining potential, except in several regions where two or more single-particle levels approach each other. We focus on two two-level crossing regions which show unexpected anti-crossing behavior and contrasting current dependences. Within a simple coherent level mixing picture, we can model the current carried through the coupled states of the probed dot provided the intrinsic variation with magnetic field of the current through the states (as if they were uncoupled) is accounted for by an appropriate interpolation scheme.Comment: 4 pages, 4 figures, accepted for publication in Physica E in MSS 13 conference proceeding

    Single-shot carrier-envelope-phase measurement in ambient air

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    The ability to measure and control the carrier envelope phase (CEP) of few-cycle laser pulses is of paramount importance for both frequency metrology and attosecond science. Here, we present a phase meter relying on the CEP-dependent photocurrents induced by circularly polarized few-cycle pulses focused between electrodes in ambient air. The new device facilitates compact single-shot, CEP measurements under ambient conditions and promises CEP tagging at repetition rates orders of magnitude higher than most conventional CEP detection schemes as well as straightforward implementation at longer wavelengths

    Π­Π»Π΅ΠΊΡ‚Ρ€ΠΎΠ½Π½Ρ‹Π΅ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ рСсурсы ΠΏΡ€ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠΈ тСхнологичСских процСссов микроэлСктроники

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    The possibilities of an advanced student studies of the technological processes of the integrated circuits fabrication by means of educational Internet sites are reviewed. Example of the Internet site that host specialized simulation programs and basic technological and physical parameters calculators is presented.Π Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°ΡŽΡ‚ΡΡ возмоТности использования ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π˜Π½Ρ‚Π΅Ρ€Π½Π΅Ρ‚-рСсурсов для ΡƒΠ³Π»ΡƒΠ±Π»Π΅Π½Π½ΠΎΠ³ΠΎ изучСния студСнтами тСхнологичСских процСссов создания ΠΈΠ½Ρ‚Π΅Π³Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… схСм. ΠŸΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ΡΡ ΠΏΡ€ΠΈΠΌΠ΅Ρ€ сайта, Π½Π° ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΌ Ρ€Π°Π·ΠΌΠ΅Ρ‰Π΅Π½Ρ‹ ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Π΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ ΠΈ ΠΊΠ°Π»ΡŒΠΊΡƒΠ»ΡΡ‚ΠΎΡ€Ρ‹ ΠΏΠΎ расчСтам основных тСхнологичСских ΠΈ физичСских ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ²

    Improving Phrap-Based Assembly of the Rat Using β€œReliable” Overlaps

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    The assembly methods used for whole-genome shotgun (WGS) data have a major impact on the quality of resulting draft genomes. We present a novel algorithm to generate a set of β€œreliable” overlaps based on identifying repeat k-mers. To demonstrate the benefits of using reliable overlaps, we have created a version of the Phrap assembly program that uses only overlaps from a specific list. We call this version PhrapUMD. Integrating PhrapUMD and our β€œreliable-overlap” algorithm with the Baylor College of Medicine assembler, Atlas, we assemble the BACs from the Rattus norvegicus genome project. Starting with the same data as the Nov. 2002 Atlas assembly, we compare our results and the Atlas assembly to the 4.3 Mb of rat sequence in the 21 BACs that have been finished. Our version of the draft assembly of the 21 BACs increases the coverage of finished sequence from 93.4% to 96.3%, while simultaneously reducing the base error rate from 4.5 to 1.1 errors per 10,000 bases. There are a number of ways of assessing the relative merits of assemblies when the finished sequence is available. If one views the overall quality of an assembly as proportional to the inverse of the product of the error rate and sequence missed, then the assembly presented here is seven times better. The UMD Overlapper with options for reliable overlaps is available from the authors at http://www.genome.umd.edu. We also provide the changes to the Phrap source code enabling it to use only the reliable overlaps

    Multi-Zone Shell Model for Turbulent Wall Bounded Flows

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    We suggested a \emph{Multi-Zone Shell} (MZS) model for wall-bounded flows accounting for the space inhomogeneity in a "piecewise approximation", in which cross-section area of the flow, SS, is subdivided into "jj-zones". The area of the first zone, responsible for the core of the flow, S1≃S/2S_1\simeq S/2, and areas of the next jj-zones, SjS_j, decrease towards the wall like Sj∝2βˆ’jS_j\propto 2^{-j}. In each jj-zone the statistics of turbulence is assumed to be space homogeneous and is described by the set of "shell velocities" unj(t)u_{nj}(t) for turbulent fluctuations of the scale ∝2βˆ’n\propto 2^{-n}. The MZS-model includes a new set of complex variables, Vj(t)V_j(t), j=1,2,...∞j=1,2,... \infty, describing the amplitudes of the near wall coherent structures of the scale sj∼2βˆ’js_j\sim 2^{-j} and responsible for the mean velocity profile. Suggested MZS-equations of motion for unj(t)u_{nj}(t) and Vj(t)V_j(t) preserve the actual conservations laws (energy, mechanical and angular momenta), respect the existing symmetries (including Galilean and scale invariance) and account for the type of the non-linearity in the Navier-Stokes equation, dimensional reasoning, etc. The MZS-model qualitatively describes important characteristics of the wall bounded turbulence, e.g., evolution of the mean velocity profile with increasing Reynolds number, \RE, from the laminar profile towards the universal logarithmic profile near the flat-plane boundary layer as \RE\to \infty.Comment: 27 pages, 17 figs, included, PRE, submitte

    Π‘ΠΏΡ–Ρ€ΠΎ[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΡ–Ρ€Π°Π½ΠΎ[3,2-с][1,2]оксатіїн-4,3’-Ρ–Π½Π΄ΠΎΠ»]-3-ΠΊΠ°Ρ€Π±ΠΎΠ½Ρ–Ρ‚Ρ€ΠΈΠ» 5,5-діоксиди: синтСз Ρ– вивчСння Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΡ— активності

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    The development of medicines with several pharmacological activities, including the analgesic, anti-inflammatory and antimicrobial properties, is one of the challenging tasks of modern medicinal chemistry.Aim. To expand the range of novel spiro-condensed derivatives of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, and study the biological activity of the substances obtained.Results and discussions. The target compounds were synthesized as a result of the interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile and isatins. When using ethyl cyanoacetate the interaction appeared to be much more complicated and requires further research. The study of the biological activity has revealed the compounds with the analgesic properties and the antimicrobial effect against gram-positive strains.Experimental part. Two new 2-amino-2’-oxospiro[4H-pyrano[3,2-c][1,2]benzoxathiine-4,3’-indoline]-3-carbonitrile 5,5-dioxides were synthesized by the three-component reaction based on 1,2-benzoxathiin-4(3H)-one 2,2-dioxide. The anti-inflammatory activity was studied on the model of the carrageenan induced paw edema, and the analgesic activity was assessed on the model of the local inflammatory hyperalgesia. The study of the antimicrobial activity of the compounds obtained was performed by the agar well diffusion method.Conclusions. New spiro[benzo[Π΅]pyrano[3,2-c][1,2]oxathiin-4,3’-indolil]-3-carbonitrile 5,5-dioxides have been synthesized. The compounds obtained have revealed high levels of the analgesic properties and the antimicrobial activity. The latter exceeds the activity of the reference drugs, and has appeared to be higher against grampositive bacteria.Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° лСкарствСнных срСдств с нСсколькими Π²ΠΈΠ΄Π°ΠΌΠΈ фармакологичСской активности, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΠ΅, ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ ΠΈ Π°Π½Ρ‚ΠΈΠΌΠΈΠΊΡ€ΠΎΠ±Π½Ρ‹Π΅ свойства, являСтся ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π²Π°ΠΆΠ½Ρ‹Ρ… Π·Π°Π΄Π°Ρ‡ соврСмСнной мСдицинской Ρ…ΠΈΠΌΠΈΠΈ.ЦСль. Π Π°ΡΡˆΠΈΡ€ΠΈΡ‚ΡŒ ряд Π½ΠΎΠ²Ρ‹Ρ… спирокондСнсированных ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Ρ… 1,2-бСнзоксатиин-4(3Н)-ΠΎΠ½ 2,2-диоксида ΠΈ ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… вСщСств.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. Π¦Π΅Π»Π΅Π²Ρ‹Π΅ соСдинСния Π±Ρ‹Π»ΠΈ синтСзированы Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ взаимодСйствия 1,2-бСнзоксатиин-4(3Н)-ΠΎΠ½ 2,2-диоксида, ΠΌΠ°Π»ΠΎΠ½ΠΎΠ΄ΠΈΠ½ΠΈΡ‚Ρ€ΠΈΠ»Π° ΠΈ ΠΈΠ·Π°Ρ‚ΠΈΠ½ΠΎΠ². Π’ случаС использования этилцианоацСтата Π² качСствС ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Π½ΠΈΡ‚Ρ€ΠΈΠ»Π° взаимодСйствиС оказалось Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ слоТным ΠΈ нуТдаСтся Π² дальнСйшСм ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠΈ. ИсслСдованиС биологичСской активности выявило соСдинСния с Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΠΌΠΈ свойствами ΠΈ Π°Π½Ρ‚ΠΈΠΌΠΈΠΊΡ€ΠΎΠ±Π½Ρ‹ΠΌ дСйствиСм Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ Π³Ρ€Π°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… ΡˆΡ‚Π°ΠΌΠΌΠΎΠ².Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π°Ρ Ρ‡Π°ΡΡ‚ΡŒ. Π”Π²Π° Π½ΠΎΠ²Ρ‹Ρ… 2-Π°ΠΌΠΈΠ½ΠΎ-2’-оксоспиро[4Н-ΠΏΠΈΡ€Π°Π½ΠΎ[3,2-с][1,2]бСнзоксатиин-4,3’-ΠΈΠ½Π΄ΠΎΠ»ΠΈΠ½]-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΡ‚Ρ€ΠΈΠ» 5,5-диоксида Π±Ρ‹Π»ΠΈ синтСзированы с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Ρ‚Ρ€Π΅Ρ…ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ Π½Π° основС 1,2-бСнзоксатиин-4(3Н)-ΠΎΠ½ 2,2-диоксида. ΠŸΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈΠ·ΡƒΡ‡Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΊΠ°Ρ€Π°Π³Π΅Π½ΠΈΠ½-ΠΈΠ½Π΄ΡƒΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π΅ΠΊΠ°, Π° Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΎΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ локальной Π²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅Ρ€Π°Π»Π³Π΅Π·ΠΈΠΈ. Π‘Ρ‹Π»ΠΎ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ исслСдованиС Π°Π½Ρ‚ΠΈΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΠΎΠΉ активности ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… соСдинСний ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡ„Ρ„ΡƒΠ·ΠΈΠΈ Π² Π°Π³Π°Ρ€.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π‘ΠΈΠ½Ρ‚Π΅Π·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π½ΠΎΠ²Ρ‹Π΅ спиро[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΠΈΡ€Π°Π½ΠΎ[3,2-с][1,2]оксатиин-4,3’-ΠΈΠ½Π΄ΠΎΠ»ΠΈΠ»]-3-ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΡ‚Ρ€ΠΈΠ» 5,5-диоксиды. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ соСдинСния проявили Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΠ΅ свойства ΠΈ Π°Π½Ρ‚ΠΈΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, которая ΠΏΡ€Π΅Π²Ρ‹ΡˆΠ°Π΅Ρ‚ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² сравнСния ΠΈ оказалась Π²Ρ‹ΡˆΠ΅ Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ Π³Ρ€Π°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ.Π ΠΎΠ·Ρ€ΠΎΠ±ΠΊΠ° Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΈΡ… засобів, Ρ‰ΠΎ Π²ΠΎΠ»ΠΎΠ΄Ρ–ΡŽΡ‚ΡŒ Π΄Π΅ΠΊΡ–Π»ΡŒΠΊΠΎΠΌΠ° Π²ΠΈΠ΄Π°ΠΌΠΈ Ρ„Π°Ρ€ΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΡ— активності, Π²ΠΊΠ»ΡŽΡ‡Π°ΡŽΡ‡ΠΈ Π·Π½Π΅Π±ΠΎΠ»ΡŽΠ²Π°Π»ΡŒΠ½Ρƒ, ΠΏΡ€ΠΎΡ‚ΠΈΠ·Π°ΠΏΠ°Π»ΡŒΠ½Ρƒ Ρ‚Π° Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½Ρƒ, Ρ” ΠΎΠ΄Π½ΠΈΠΌ Π· Π²Π°ΠΆΠ»ΠΈΠ²ΠΈΡ… завдань сучасної ΠΌΠ΅Π΄ΠΈΡ‡Π½ΠΎΡ— Ρ…Ρ–ΠΌΡ–Ρ—.ΠœΠ΅Ρ‚Π°. Π ΠΎΠ·ΡˆΠΈΡ€ΠΈΡ‚ΠΈ ряд Π½ΠΎΠ²ΠΈΡ… спірокондСнсованих ΠΏΠΎΡ…Ρ–Π΄Π½ΠΈΡ… 1,2-бСнзоксатіїн-4(3Н)-ΠΎΠ½ 2,2-діоксиду Ρ– дослідити Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½Ρƒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΡ… Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. Π¦Ρ–Π»ΡŒΠΎΠ²Ρ– сполуки Π±ΡƒΠ»ΠΈ синтСзовані Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ– Π²Π·Π°Ρ”ΠΌΠΎΠ΄Ρ–Ρ— 1,2-бСнзоксатіїн-4(3Н)-ΠΎΠ½ 2,2-діоксиду, ΠΌΠ°Π»ΠΎΠ½ΠΎΠ΄ΠΈΠ½Ρ–Ρ‚Ρ€ΠΈΠ»Ρƒ Ρ‚Π° Ρ–Π·Π°Ρ‚ΠΈΠ½Ρ–Π². Π£ Π²ΠΈΠΏΠ°Π΄ΠΊΡƒ використання Π΅Ρ‚ΠΈΠ»Ρ†Ρ–Π°Π½ΠΎΠ°Ρ†Π΅Ρ‚Π°Ρ‚Ρƒ як ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Π½Ρ–Ρ‚Ρ€ΠΈΠ»Ρƒ взаємодія виявилася Π½Π°Π±Π°Π³Π°Ρ‚ΠΎ ΡΠΊΠ»Π°Π΄Π½Ρ–ΡˆΠΎΡŽ Ρ– ΠΏΠΎΡ‚Ρ€Π΅Π±ΡƒΡ” ΠΏΠΎΠ΄Π°Π»ΡŒΡˆΠΈΡ… Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ. ВивчСння Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎΡ— активності виявило сполуки Π· Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π½ΠΈΠΌΠΈ властивостями Ρ‚Π° Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΎΡŽ Π΄Ρ–Ρ”ΡŽ ΠΏΡ€ΠΎΡ‚ΠΈ Π³Ρ€Π°ΠΌΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½ΠΈΡ… ΡˆΡ‚Π°ΠΌΡ–Π².Π•ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π° частина. Π”Π²Π° Π½ΠΎΠ²ΠΈΡ… 2-Π°ΠΌΡ–Π½ΠΎ-2’-оксоспіро[4H-ΠΏΡ–Ρ€Π°Π½ΠΎ[3,2-с][1,2]бСнзоксатіїн-4,3’-Ρ–Π½Π΄ΠΎΠ»Ρ–Π½]-3-ΠΊΠ°Ρ€Π±ΠΎΠ½Ρ–Ρ‚Ρ€ΠΈΠ» 5,5-діоксиди Π±ΡƒΠ»ΠΈ синтСзовані Π·Π° допомогою Ρ‚Ρ€ΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π½ΠΎΡ— Ρ€Π΅Π°ΠΊΡ†Ρ–Ρ— Π½Π° основі 1,2-бСнзоксатіїн-4(3Н)-ΠΎΠ½ 2,2-діоксиду. ΠŸΡ€ΠΎΡ‚ΠΈΠ·Π°ΠΏΠ°Π»ΡŒΠ½Ρƒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ Π²ΠΈΠ²Ρ‡Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– ΠΊΠ°Ρ€Π°Π³Π΅Π½Ρ–Π½ΠΎΠ²ΠΎΠ³ΠΎ набряку, Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π½Ρƒ Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ ΠΎΡ†Ρ–Π½ΡŽΠ²Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ– місцСвої Π·Π°ΠΏΠ°Π»ΡŒΠ½ΠΎΡ— Π³Ρ–ΠΏΠ΅Ρ€Π°Π»Π³Π΅Π·Ρ–Ρ—. Π‘ΡƒΠ»ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ– дослідТСння Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΎΡ— активності ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΈΡ… сполук ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡ„ΡƒΠ·Ρ–Ρ— Π² Π°Π³Π°Ρ€.Висновки. Π‘ΠΈΠ½Ρ‚Π΅Π·ΠΎΠ²Π°Π½ΠΎ Π½ΠΎΠ²Ρ– спіро[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΡ–Ρ€Π°Π½ΠΎ[3,2-с][1,2]оксатіїн-4,3’-Ρ–Π½Π΄ΠΎΠ»]-3-ΠΊΠ°Ρ€Π±ΠΎΠ½Ρ–Ρ‚Ρ€ΠΈΠ» 5,5-діоксиди. ΠžΡ‚Ρ€ΠΈΠΌΠ°Π½Ρ– сполуки виявили високий Ρ€Ρ–Π²Π΅Π½ΡŒ Π°Π½Π°Π»ΡŒΠ³Π΅Ρ‚ΠΈΡ‡Π½ΠΎΡ— Ρ‚Π° Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΎΡ— активності. ΠžΡΡ‚Π°Π½Π½Ρ ΠΏΠ΅Ρ€Π΅Π²ΠΈΡ‰ΡƒΡ” Π°ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ рСфСрСнс-ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² Ρ– виявилася Π±Ρ–Π»ΡŒΡˆ Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡŽ ΠΏΡ€ΠΎΡ‚ΠΈ Π³Ρ€Π°ΠΌΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½ΠΈΡ… Π±Π°ΠΊΡ‚Π΅Ρ€Ρ–ΠΉ
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