1,907 research outputs found
ΠΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ Π·Π°Π΄Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΏΠΎΠ»ΡΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠ΅ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ ΡΠ°ΠΉΡΠΎΠ² ΡΠ΅ΡΠΈ ΠΠ½ΡΠ΅ΡΠ½Π΅Ρ
The report examines the authorβs experience on the use of educational Internet sites by students in order to solve problems in the courses of semiconductor materials science and solid-state electronics. The pros and cons of the used websites are discussed, and the difficulties of the students work in an English-speaking environment are noted.Π Π΄ΠΎΠΊΠ»Π°Π΄Π΅ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΡΡΡ ΠΎΠΏΡΡ Π°Π²ΡΠΎΡΠ° ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ°ΠΉΡΠΎΠ² ΠΠ½ΡΠ΅ΡΠ½Π΅ΡΠ° ΠΏΡΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π·Π°Π΄Π°Ρ ΠΏΠΎ ΠΊΡΡΡΠ°ΠΌ ΠΏΠΎΠ»ΡΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠΈ. Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΡ
ΡΠ°ΠΉΡΠΎΠ², ΠΎΡΠΌΠ΅ΡΠ°ΡΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠ°Π±ΠΎΡΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π² Π°Π½Π³Π»ΠΎΡΠ·ΡΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅
Probation Institution in Russia
The author deals with the problems of taking under control the persons after a release from custody and rendering them help in social adaptation
Two level anti-crossings high up in the single-particle energy spectrum of a quantum dot
We study the evolution with magnetic field of the single-particle energy
levels high up in the energy spectrum of one dot as probed by the ground state
of the adjacent dot in a weakly coupled vertical quantum dot molecule. We find
that the observed spectrum is generally well accounted for by the calculated
spectrum for a two-dimensional elliptical parabolic confining potential, except
in several regions where two or more single-particle levels approach each
other. We focus on two two-level crossing regions which show unexpected
anti-crossing behavior and contrasting current dependences. Within a simple
coherent level mixing picture, we can model the current carried through the
coupled states of the probed dot provided the intrinsic variation with magnetic
field of the current through the states (as if they were uncoupled) is
accounted for by an appropriate interpolation scheme.Comment: 4 pages, 4 figures, accepted for publication in Physica E in MSS 13
conference proceeding
Single-shot carrier-envelope-phase measurement in ambient air
The ability to measure and control the carrier envelope phase (CEP) of
few-cycle laser pulses is of paramount importance for both frequency metrology
and attosecond science. Here, we present a phase meter relying on the
CEP-dependent photocurrents induced by circularly polarized few-cycle pulses
focused between electrodes in ambient air. The new device facilitates compact
single-shot, CEP measurements under ambient conditions and promises CEP tagging
at repetition rates orders of magnitude higher than most conventional CEP
detection schemes as well as straightforward implementation at longer
wavelengths
ΠΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠ΅ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ΅ΡΡΡΡΡ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠΈ
The possibilities of an advanced student studies of the technological processes of the integrated circuits fabrication by means of educational Internet sites are reviewed. Example of the Internet site that host specialized simulation programs and basic technological and physical parameters calculators is presented.Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΠ½ΡΠ΅ΡΠ½Π΅Ρ-ΡΠ΅ΡΡΡΡΠΎΠ² Π΄Π»Ρ ΡΠ³Π»ΡΠ±Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΈΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΡΡ
ΡΡ
Π΅ΠΌ. ΠΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΏΡΠΈΠΌΠ΅Ρ ΡΠ°ΠΉΡΠ°, Π½Π° ΠΊΠΎΡΠΎΡΠΎΠΌ ΡΠ°Π·ΠΌΠ΅ΡΠ΅Π½Ρ ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΡΡΡΠΈΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΈ ΠΊΠ°Π»ΡΠΊΡΠ»ΡΡΠΎΡΡ ΠΏΠΎ ΡΠ°ΡΡΠ΅ΡΠ°ΠΌ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ²
Improving Phrap-Based Assembly of the Rat Using βReliableβ Overlaps
The assembly methods used for whole-genome shotgun (WGS) data have a major impact on the quality of resulting draft genomes. We present a novel algorithm to generate a set of βreliableβ overlaps based on identifying repeat k-mers. To demonstrate the benefits of using reliable overlaps, we have created a version of the Phrap assembly program that uses only overlaps from a specific list. We call this version PhrapUMD. Integrating PhrapUMD and our βreliable-overlapβ algorithm with the Baylor College of Medicine assembler, Atlas, we assemble the BACs from the Rattus norvegicus genome project. Starting with the same data as the Nov. 2002 Atlas assembly, we compare our results and the Atlas assembly to the 4.3 Mb of rat sequence in the 21 BACs that have been finished. Our version of the draft assembly of the 21 BACs increases the coverage of finished sequence from 93.4% to 96.3%, while simultaneously reducing the base error rate from 4.5 to 1.1 errors per 10,000 bases. There are a number of ways of assessing the relative merits of assemblies when the finished sequence is available. If one views the overall quality of an assembly as proportional to the inverse of the product of the error rate and sequence missed, then the assembly presented here is seven times better. The UMD Overlapper with options for reliable overlaps is available from the authors at http://www.genome.umd.edu. We also provide the changes to the Phrap source code enabling it to use only the reliable overlaps
Multi-Zone Shell Model for Turbulent Wall Bounded Flows
We suggested a \emph{Multi-Zone Shell} (MZS) model for wall-bounded flows
accounting for the space inhomogeneity in a "piecewise approximation", in which
cross-section area of the flow, , is subdivided into "-zones". The area
of the first zone, responsible for the core of the flow, , and
areas of the next -zones, , decrease towards the wall like . In each -zone the statistics of turbulence is assumed to be space
homogeneous and is described by the set of "shell velocities" for
turbulent fluctuations of the scale . The MZS-model includes a
new set of complex variables, , , describing the
amplitudes of the near wall coherent structures of the scale
and responsible for the mean velocity profile. Suggested MZS-equations of
motion for and preserve the actual conservations laws
(energy, mechanical and angular momenta), respect the existing symmetries
(including Galilean and scale invariance) and account for the type of the
non-linearity in the Navier-Stokes equation, dimensional reasoning, etc. The
MZS-model qualitatively describes important characteristics of the wall bounded
turbulence, e.g., evolution of the mean velocity profile with increasing
Reynolds number, \RE, from the laminar profile towards the universal
logarithmic profile near the flat-plane boundary layer as \RE\to \infty.Comment: 27 pages, 17 figs, included, PRE, submitte
Π‘ΠΏΡΡΠΎ[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΡΡΠ°Π½ΠΎ[3,2-Ρ][1,2]ΠΎΠΊΡΠ°ΡΡΡΠ½-4,3β-ΡΠ½Π΄ΠΎΠ»]-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΡΡΡΠΈΠ» 5,5-Π΄ΡΠΎΠΊΡΠΈΠ΄ΠΈ: ΡΠΈΠ½ΡΠ΅Π· Ρ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
The development of medicines with several pharmacological activities, including the analgesic, anti-inflammatory and antimicrobial properties, is one of the challenging tasks of modern medicinal chemistry.Aim. To expand the range of novel spiro-condensed derivatives of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, and study the biological activity of the substances obtained.Results and discussions. The target compounds were synthesized as a result of the interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile and isatins. When using ethyl cyanoacetate the interaction appeared to be much more complicated and requires further research. The study of the biological activity has revealed the compounds with the analgesic properties and the antimicrobial effect against gram-positive strains.Experimental part. Two new 2-amino-2β-oxospiro[4H-pyrano[3,2-c][1,2]benzoxathiine-4,3β-indoline]-3-carbonitrile 5,5-dioxides were synthesized by the three-component reaction based on 1,2-benzoxathiin-4(3H)-one 2,2-dioxide. The anti-inflammatory activity was studied on the model of the carrageenan induced paw edema, and the analgesic activity was assessed on the model of the local inflammatory hyperalgesia. The study of the antimicrobial activity of the compounds obtained was performed by the agar well diffusion method.Conclusions. New spiro[benzo[Π΅]pyrano[3,2-c][1,2]oxathiin-4,3β-indolil]-3-carbonitrile 5,5-dioxides have been synthesized. The compounds obtained have revealed high levels of the analgesic properties and the antimicrobial activity. The latter exceeds the activity of the reference drugs, and has appeared to be higher against grampositive bacteria.Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² Ρ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΠΌΠΈ Π²ΠΈΠ΄Π°ΠΌΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π²ΠΊΠ»ΡΡΠ°Ρ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π²Π°ΠΆΠ½ΡΡ
Π·Π°Π΄Π°Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΈ.Π¦Π΅Π»Ρ. Π Π°ΡΡΠΈΡΠΈΡΡ ΡΡΠ΄ Π½ΠΎΠ²ΡΡ
ΡΠΏΠΈΡΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΠΈΠΈΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π° ΠΈ ΠΈΠ·ΡΡΠΈΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ².Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π¦Π΅Π»Π΅Π²ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Π±ΡΠ»ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ 1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΠΈΠΈΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π°, ΠΌΠ°Π»ΠΎΠ½ΠΎΠ΄ΠΈΠ½ΠΈΡΡΠΈΠ»Π° ΠΈ ΠΈΠ·Π°ΡΠΈΠ½ΠΎΠ². Π ΡΠ»ΡΡΠ°Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΈΠ»ΡΠΈΠ°Π½ΠΎΠ°ΡΠ΅ΡΠ°ΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½ΠΈΡΡΠΈΠ»Π° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΎΠΊΠ°Π·Π°Π»ΠΎΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ ΡΠ»ΠΎΠΆΠ½ΡΠΌ ΠΈ Π½ΡΠΆΠ΄Π°Π΅ΡΡΡ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²ΡΡΠ²ΠΈΠ»ΠΎ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ Ρ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΡΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ².ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. ΠΠ²Π° Π½ΠΎΠ²ΡΡ
2-Π°ΠΌΠΈΠ½ΠΎ-2β-ΠΎΠΊΡΠΎΡΠΏΠΈΡΠΎ[4Π-ΠΏΠΈΡΠ°Π½ΠΎ[3,2-Ρ][1,2]Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΠΈΠΈΠ½-4,3β-ΠΈΠ½Π΄ΠΎΠ»ΠΈΠ½]-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΡΡΠΈΠ» 5,5-Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π° Π±ΡΠ»ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΡΠ΅Ρ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ 1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΠΈΠΈΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π°. ΠΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠ·ΡΡΠ°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΊΠ°ΡΠ°Π³Π΅Π½ΠΈΠ½-ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΡΠ΅ΠΊΠ°, Π° Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠΉ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ°Π»Π³Π΅Π·ΠΈΠΈ. ΠΡΠ»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΡΠ·ΠΈΠΈ Π² Π°Π³Π°Ρ.ΠΡΠ²ΠΎΠ΄Ρ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ Π½ΠΎΠ²ΡΠ΅ ΡΠΏΠΈΡΠΎ[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΠΈΡΠ°Π½ΠΎ[3,2-Ρ][1,2]ΠΎΠΊΡΠ°ΡΠΈΠΈΠ½-4,3β-ΠΈΠ½Π΄ΠΎΠ»ΠΈΠ»]-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΡΡΠΈΠ» 5,5-Π΄ΠΈΠΎΠΊΡΠΈΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΠΏΡΠΎΡΠ²ΠΈΠ»ΠΈ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΏΡΠ΅Π²ΡΡΠ°Π΅Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ Π²ΡΡΠ΅ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ.Π ΠΎΠ·ΡΠΎΠ±ΠΊΠ° Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ², ΡΠΎ Π²ΠΎΠ»ΠΎΠ΄ΡΡΡΡ Π΄Π΅ΠΊΡΠ»ΡΠΊΠΎΠΌΠ° Π²ΠΈΠ΄Π°ΠΌΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈ Π·Π½Π΅Π±ΠΎΠ»ΡΠ²Π°Π»ΡΠ½Ρ, ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ ΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½Ρ, Ρ ΠΎΠ΄Π½ΠΈΠΌ Π· Π²Π°ΠΆΠ»ΠΈΠ²ΠΈΡ
Π·Π°Π²Π΄Π°Π½Ρ ΡΡΡΠ°ΡΠ½ΠΎΡ ΠΌΠ΅Π΄ΠΈΡΠ½ΠΎΡ Ρ
ΡΠΌΡΡ.ΠΠ΅ΡΠ°. Π ΠΎΠ·ΡΠΈΡΠΈΡΠΈ ΡΡΠ΄ Π½ΠΎΠ²ΠΈΡ
ΡΠΏΡΡΠΎΠΊΠΎΠ½Π΄Π΅Π½ΡΠΎΠ²Π°Π½ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΡΡΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΡΠΎΠΊΡΠΈΠ΄Ρ Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΈΡΠΈ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ
ΡΠ΅ΡΠΎΠ²ΠΈΠ½.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π¦ΡΠ»ΡΠΎΠ²Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ Π±ΡΠ»ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½Ρ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ 1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΡΡΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΡΠΎΠΊΡΠΈΠ΄Ρ, ΠΌΠ°Π»ΠΎΠ½ΠΎΠ΄ΠΈΠ½ΡΡΡΠΈΠ»Ρ ΡΠ° ΡΠ·Π°ΡΠΈΠ½ΡΠ². Π£ Π²ΠΈΠΏΠ°Π΄ΠΊΡ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½Ρ Π΅ΡΠΈΠ»ΡΡΠ°Π½ΠΎΠ°ΡΠ΅ΡΠ°ΡΡ ΡΠΊ ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½ΡΡΡΠΈΠ»Ρ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ Π²ΠΈΡΠ²ΠΈΠ»Π°ΡΡ Π½Π°Π±Π°Π³Π°ΡΠΎ ΡΠΊΠ»Π°Π΄Π½ΡΡΠΎΡ Ρ ΠΏΠΎΡΡΠ΅Π±ΡΡ ΠΏΠΎΠ΄Π°Π»ΡΡΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ. ΠΠΈΠ²ΡΠ΅Π½Π½Ρ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΠΈΡΠ²ΠΈΠ»ΠΎ ΡΠΏΠΎΠ»ΡΠΊΠΈ Π· Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ½ΠΈΠΌΠΈ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡΠΌΠΈ ΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π΄ΡΡΡ ΠΏΡΠΎΡΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
ΡΡΠ°ΠΌΡΠ².ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°. ΠΠ²Π° Π½ΠΎΠ²ΠΈΡ
2-Π°ΠΌΡΠ½ΠΎ-2β-ΠΎΠΊΡΠΎΡΠΏΡΡΠΎ[4H-ΠΏΡΡΠ°Π½ΠΎ[3,2-Ρ][1,2]Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΡΡΠ½-4,3β-ΡΠ½Π΄ΠΎΠ»ΡΠ½]-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΡΡΡΠΈΠ» 5,5-Π΄ΡΠΎΠΊΡΠΈΠ΄ΠΈ Π±ΡΠ»ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½Ρ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΡΠΈΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΠΎΡ ΡΠ΅Π°ΠΊΡΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ 1,2-Π±Π΅Π½Π·ΠΎΠΊΡΠ°ΡΡΡΠ½-4(3Π)-ΠΎΠ½ 2,2-Π΄ΡΠΎΠΊΡΠΈΠ΄Ρ. ΠΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π²ΠΈΠ²ΡΠ°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΠΊΠ°ΡΠ°Π³Π΅Π½ΡΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π½Π°Π±ΡΡΠΊΡ, Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΎΡΡΠ½ΡΠ²Π°Π»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΠΌΡΡΡΠ΅Π²ΠΎΡ Π·Π°ΠΏΠ°Π»ΡΠ½ΠΎΡ Π³ΡΠΏΠ΅ΡΠ°Π»Π³Π΅Π·ΡΡ. ΠΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΡΡΠΈΠΌΠ°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π΄ΠΈΡΡΠ·ΡΡ Π² Π°Π³Π°Ρ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ Π½ΠΎΠ²Ρ ΡΠΏΡΡΠΎ[Π±Π΅Π½Π·ΠΎ[Π΅]ΠΏΡΡΠ°Π½ΠΎ[3,2-Ρ][1,2]ΠΎΠΊΡΠ°ΡΡΡΠ½-4,3β-ΡΠ½Π΄ΠΎΠ»]-3-ΠΊΠ°ΡΠ±ΠΎΠ½ΡΡΡΠΈΠ» 5,5-Π΄ΡΠΎΠΊΡΠΈΠ΄ΠΈ. ΠΡΡΠΈΠΌΠ°Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ Π²ΠΈΡΠ²ΠΈΠ»ΠΈ Π²ΠΈΡΠΎΠΊΠΈΠΉ ΡΡΠ²Π΅Π½Ρ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΡΠ½ΠΎΡ ΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΡΡΠ°Π½Π½Ρ ΠΏΠ΅ΡΠ΅Π²ΠΈΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡΠ² Ρ Π²ΠΈΡΠ²ΠΈΠ»Π°ΡΡ Π±ΡΠ»ΡΡ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΠΏΡΠΎΡΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΡΠΉ
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