Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%–60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases. In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS. Five patients had no underlying medical illnesses, and three patients were asymptomatic. Of the seven cases, four (57%) patients sought medical advice within 1–7 days from the onset of symptoms. The three other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoV. The most common presenting symptoms were fever (57%), cough (14%), shortness of breath (14%), vomiting (28%), and diarrhea (28%). Two (28.6%) patients had platelet counts of < 150 × 109/L, and one patient had an underlying end-stage renal disease. The remaining patients presented with normal blood count, liver function, and urea and creatinine levels. The documented MERS-CoV Ct values were 32–38 for four of the seven cases. Two patients (28.6%) had abnormal chest radiographic findings of bilateral infiltration. One patient (14.3%) required ventilator support, and two patients (28.6%) required oxygen supplementation. All the seven patients were discharged without complications

The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Ho and colleagues recently drew attention to the consequences of co-infection with Influenza and HIV.1 We present four cases of combined infection with influenza and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Nasopharyngeal swabs or tracheal aspirates were tested for MERS-CoV using real-time reverse-transcription polymerase chain reaction (RT-PCR).2, 3 Samples were tested for Influenza A, B and H1N1 by rapid molecular test (GenEXper for detection of flu A, B and 2009 H1N1, Cepheid)

Dome C site testing: surface layer, free atmosphere seeing and isoplanatic angle statistics

This paper analyses 3.5 years of site testing data obtained at Dome C, Antarctica, based on measurements obtained with three DIMMs located at three different elevations. Basic statistics of the seeing and the isoplanatic angle are given, as well as the characteristic time of temporal fluctuations of these two parameters, which we found to around 30 minutes at 8 m. The 3 DIMMs are exploited as a profiler of the surface layer, and provide a robust estimation of its statistical properties. It appears to have a very sharp upper limit (less than 1 m). The fraction of time spent by each telescope above the top of the surface layer permits us to deduce a median height of between 23 m and 27 m. The comparison of the different data sets led us to infer the statistical properties of the free atmosphere seeing, with a median value of 0.36 arcsec. The C_n^2 profile inside the surface layer is also deduced from the seeing data obtained during the fraction of time spent by the 3 telescopes inside this turbulence. Statistically, the surface layer, except during the 3-month summer season, contributes to 95 percent of the total turbulence from the surface level, thus confirming the exceptional quality of the site above it

Wafer-level packaged RF-MEMS switches fabricated in a CMOS fab

Reports on wafer-level packaged RF-MEMS switches fabricated in a commercial CMOS fab. Switch fabrication is based on a metal surface micromachining process. A novel wafer-level packaging scheme is developed, whereby the switches are housed in on-chip sealed cavities using benzocyclobutene (BCB) as the bonding and sealing material. Measurements show that the influence of the wafer-level package on the RF performance can be made very small.\ud \u

Conformal Ricci collineations of static spherically symmetric spacetimes

Conformal Ricci collineations of static spherically symmetric spacetimes are studied. The general form of the vector fields generating conformal Ricci collineations is found when the Ricci tensor is non-degenerate, in which case the number of independent conformal Ricci collineations is \emph{fifteen}; the maximum number for 4-dimensional manifolds. In the degenerate case it is found that the static spherically symmetric spacetimes always have an infinite number of conformal Ricci collineations. Some examples are provided which admit non-trivial conformal Ricci collineations, and perfect fluid source of the matter

Comparison of Essential Oil of Lemongrass (Cymbopogon Citratus) Extracted with Microwave-Assisted Hydrodistillation (MAHD) and Conventional Hydrodistillation (HD) Method

The increasing demand of essential oil has opened up wide opportunities for global marketing which leads to the requirement of its competitive product in market that comes with all the advantages in term of cost, quality and its production time. Microwave-assisted hydrodistillation (MAHD) method is an advance extraction technique that takes advantage of microwave heating with the conventional hydrodistillation (HD). This research was carried out to study the effect of different MAHD parameters which were water to plant material ratio (6:1, 8:1,10:1), microwave power (200 W,250W) and extraction time (30min,60min, 90min,120min) in extraction of essential oil from Lemongrass (Cymbopogon Citratus). Its extraction yield and major constituents were analyzed and the results were compared with those of conventional HD. The optimum parameters were found at water to plant material ratio of 8:1, microwave power of 250W and 90 minutes of extraction and the yield obtained under this condition was 1.46%. The gas chromatography/mass spectrometric (GC-MS) analysis showed that the content of main constituents which were neral, geranial and myrcene were almost similar in the essential oil extracted using MAHD and conventional HD. This has proved that the use of microwave irradiation did not adversely influence the composition of essential oils. Overall, the results obtained indicate that MAHD method provided a good alternative for the extraction of essential oil from Lemongrass (Cymbopogon Citratus)