Stabilized Plane and Axisymmetric Lobatto Finite Element Models

High order elements are renowned for their high accuracy and convergence. Among them, Lobatto spectral finite elements are commonly used in explicit dynamic analyses as their mass matrices when evaluated by the Lobatto integration rule are diagonal. While there are numerous advanced first and second order elements, advanced high order elements are rarely seen. In this paper, generic stabilization schemes are devised for the reduced integrated plane and axisymmetric elements. Static and explicit dynamic tests are considered for evaluating the relatively merits of the stabilized and conventional elements. The displacement errors of the stabilized elements are less than those of the conventional Lobatto elements. When the material is nearly incompressible, the stabilized elements are also more accurate in terms of the energy error norm. This advantage is of practical importance for bio-tissue and hydrated soil analyses.postprin

A semiparametric cure model for interval-censored data

postprin

Modified and Trefftz unsymmetric finite element models

The unsymmetric finite element method employs compatible test functions but incompatible trial functions. The pertinent 8-node quadrilateral and 20-node hexahedron unsymmetric elements possess exceptional immunity to mesh distortion. It was noted later that they are not invariant and the proposed remedy is to formulate the element stiffness matrix in a local frame and then transform the matrix back to the global frame. In this paper, a more efficient approach will be proposed to secure the invariance. To our best knowledge, unsymmetric 4-node quadrilateral and 8-node hexahedron do not exist. They will be devised by using the Trefftz functions as the trial function. Numerical examples show that the two elements also possess exceptional immunity to mesh distortion with respect to other advanced elements of the same nodal configurations.postprin

A case of cerebellar hypoplasia in a Chinese infant with osteogenesis imperfecta

We report a unique case of unilateral cerebellar hypoplasia in a young Chinese girl with osteogenesis imperfecta type IV. Magnetic resonance imaging showed mild basilar invagination and impression. Although unilateral cerebellar hypoplasia and osteogenesis imperfecta may have been coincidental diagnoses, we propose possible mechanisms for unilateral cerebellar hypoplasia secondary to osteogenesis imperfecta. For example, cerebellar hypoplasia may have been because of vascular disruption or direct compression to the posterior circulation in utero. Foetuses with osteogenesis imperfecta are more susceptible to the above risks compared to the normal foetus because of associated craniocervical anomalies and a poorly ossified skull.published_or_final_versio

MMP14 regulates the lineage progression of hypertrophic chondrocytes

It is traditionally believed that chondrocytes and osteoblasts are two separate lineages with hypertrophic chondrocytes (HCs) being the terminal stage of chondrocyte differentiation, culminating in apoptosis. However, we have shown that HCs can contribute to the full osteoblast (Obs) lineage in vivo. MMP14 is a transmembrane matrix metalloproteinase responsible for matrix remodeling that is highly expressed at the chondro‐osseous junction which coincides with the transition from HCs to Obs. Knockout of Mmp14 in mice results in impaired endochondral ossification. To test whether loss of MMP14 has an impact on the HC to Obs transition, we have employed a genetic recombination approach to track and compare the fate of HCs in wild‐type and Mmp14 conditional and total null mutants. Both complete and conditional deletion of MMP14 activity results in increased number of HC‐descendent cells in the trabecular bone. Surprisingly, conditional knockout of Mmp14 in HC‐descendent cells results in increased trabecular bone formation. Our results suggest that MMP14 in general negatively regulates HC to Obs transition.postprin

Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China.

Human bocavirus (HBoV) is a novel parvovirus associated with respiratory tract diseases and gastrointestinal illness in adult and pediatric patients throughout the world. To investigate the epidemiological and genetic variation of HBoV in Guangzhou, South China, we screened 3460 throat swab samples from 1686 children and 1774 adults with acute respiratory infection symptoms for HBoV between March 2010 and February 2011, and analyzed the complete genome sequence of 2 HBoV strains. Specimens were screened for HBoV by real-time PCR and other 6 common respiratory viruses by RT-PCR or PCR. HBoV was detected in 58 (1.68%) out of 3460 samples, mostly from pediatric patients (52/58) and inpatient children (47/58). Six adult patients were detected as HBoV positive and 5 were emergency cases. Of these HBoV positive cases, 19 (32.76%) had co-pathogens including influenza virus (n = 5), RSV (n = 5), parainfluenza (n = 4), adenovirus (n = 1), coronavirus (n = 7). The complete genome sequences of 2 HBoVs strains (Genbank no. JN794565 and JN794566) were analyzed. Phylogenetic analysis showed that the 2 HBoV strains were HBoV1, and were most genetically close to ST2 (GenBank accession number DQ0000496). Recombination analysis confirmed that HBoV strain GZ9081 was an intra-genotype recombinant strain among HBoV1 variants.published_or_final_versio

PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs

Expression quantitative trait loci (eQTLs) mapping and linkage disequilibrium (LD) analysis have been widely employed to interpret findings of genome-wide association studies (GWAS). With the availability of deep sequencing data of 423 lymphoblastoid cell lines (LCLs) from six global populations and the microarray expression data, we performed eQTL analysis, identified more than 228 K SNP cis-eQTLs and 21 K indel cis-eQTLs and generated a LCL cis-eQTL database. We demonstrate that the percentages of population-shared and population-specific cis-eQTLs are comparable; while indel cis-eQTLs in the population-specific subsection make more contribution to gene expression variations than those in the population-shared subsection. We found cis-eQTLs, especially the population-shared cis-eQTLs are significantly enriched toward transcription start site. Moreover, the National Human Genome Research Institute cataloged GWAS SNPs are enriched for LCL cis-eQTLs. Specifically, 32.8% GWAS SNPs are LCL cis-eQTLs, among which 12.5% can be tagged by indel cis-eQTLs, suggesting the fundamental contribution of indel cis-eQTLs to GWAS association signals. To search for functional indels and SNPs tagging GWAS SNPs, a pipeline Post-GWAS Explorer for Functional Indels and SNPs (PExFInS) has been developed, integrating LD analysis, functional annotation from public databases, cis-eQTL mapping with our LCL cis-eQTL database and other published cis-eQTL datasets.published_or_final_versio

Study of the transient and depth-dependent swelling behavior of articular cartilage by ultrasound

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe