Establishment of Fungal Decomposition Model Based on OLS and Logistic Model

By using the OLS model, an equation for the rate of decomposing wood by a variety of fungi was established. We analyzed the effects of various fungi in the experimental data under different temperature and humidity. Based on the growth performance of different fungi at different temperatures and humidity, we use the method of systematic cluster to divide the fungi into 5 categories, and introduce competition levels as the viability of different species of fungi. We have established a logistic model that introduces competition levels to obtain a fungal habitat model. The fungal habitat model includes predictions about the relative advantages and disadvantages for each species and combinations of species likely to persist, and do so for different environments including arid, semi-arid, temperate, arboreal, and tropical rain forests

Advances in Targeted Therapy and Immunotherapy for Non-small Cell Lung Cancer Based on Accurate Molecular Typing

The essence of precision medicine is to achieve the goal of “individualized treatment” through genotyping of patients and targeted therapy. At present, the pathogenic genes of non-small cell lung cancer (NSCLC) have been studied most thoroughly and targeted therapy based on genotyping has been the most successful. This paper focuses on the precision treatment of NSCLC based on genotyping, comparing gene detection methods and summarize the latest progress of NSCLC immunotherapy

Negative symptom dimensions and social functioning in Chinese patients with schizophrenia

ObjectiveNegative symptoms can seriously affect social functioning in patients with schizophrenia. However, the role of various components of negative symptoms in social functioning remains unclear. This study aimed to explore the associations among three different dimensions of negative symptoms (i.e., communication, emotion, and motivation) and social functioning to identify potential therapeutic targets.MethodsThis cross-sectional study enrolled 202 Chinese participants with schizophrenia. Negative symptoms were evaluated using the Negative Symptom Assessment (NSA). Social functioning was represented by the Personal and Social Performance Scale (PSP) total score and employment status. Correlation analysis was conducted to clarify the relationship between negative symptoms and the PSP total score. Regression analysis was performed to explore the determinants of the PSP total score and employment status, considering negative symptoms and possible confounders, such as demographic features, positive symptoms, cognitive symptoms, depressive symptoms, and extrapyramidal side effects.ResultsThe PSP total score was correlated with all three dimensions of negative symptoms (i.e., emotion, motivation, and communication; rs = –0.509, –0.662, and –0.657, respectively). Motivation, instead of emotion or communication, predicted both low PSP total scores and unemployment.ConclusionSocial functioning in patients with schizophrenia was significantly related to motivation. Further studies should focus on motivation and consider it as a therapeutic target to improve patients’ social functioning

Long-distance continuous-variable quantum key distribution over 202.81 km fiber

Quantum key distribution (QKD) provides secure keys resistant to code-breaking quantum computers. The continuous-variable version of QKD offers the advantages of higher secret key rates in metropolitan areas, as well as the use of standard telecom components that can operate at room temperature. However, the transmission distance of these systems (compared with discrete-variable systems) are currently limited and considered unsuitable for long-distance distribution. Herein, we report the experimental results of long distance continuous-variable QKD over 202.81 km of ultralow-loss optical fiber by suitably controlling the excess noise and employing highly-efficient reconciliation procedures. This record-breaking implementation of the continuous-variable QKD doubles the previous distance record and shows the road for long-distance and large-scale secure QKD using room-temperature standard telecom components

DNA-Interacting Characteristics of the Archaeal Rudiviral Protein SIRV2_Gp1

Whereas the infection cycles of many bacterial and eukaryotic viruses have been characterized in detail, those of archaeal viruses remain largely unexplored. Recently, studies on a few model archaeal viruses such as SIRV2 (Sulfolobus islandicus rod-shaped virus) have revealed an unusual lysis mechanism that involves the formation of pyramidal egress structures on the host cell surface. To expand understanding of the infection cycle of SIRV2, we aimed to functionally characterize gp1, which is a SIRV2 gene with unknown function. The SIRV2_Gp1 protein is highly expressed during early stages of infection and it is the only protein that is encoded twice on the viral genome. It harbours a helix-turn-helix motif and was therefore hypothesized to bind DNA. The DNA-binding behavior of SIRV2_Gp1 was characterized with electrophoretic mobility shift assays and atomic force microscopy. We provide evidence that the protein interacts with DNA and that it forms large aggregates, thereby causing extreme condensation of the DNA. Furthermore, the N-terminal domain of the protein mediates toxicity to the viral host Sulfolobus. Our findings may lead to biotechnological applications, such as the development of a toxic peptide for the containment of pathogenic bacteria, and add to our understanding of the Rudiviral infection cycle.status: publishe