Comparison of acoustic travel-time measurement of solar meridional circulation from SDO/HMI and SOHO/MDI

Time-distance helioseismology is one of the primary tools for studying the solar meridional circulation. However, travel-time measurements of the subsurface meridional flow suffer from a variety of systematic errors, such as a center-to-limb variation and an offset due to the P-angle uncertainty of solar images. Here we apply the time-distance technique to contemporaneous medium-degree Dopplergrams produced by SOHO/MDI and SDO/HMI to obtain the travel-time difference caused by meridional circulation throughout the solar convection zone. The P-angle offset in MDI images is measured by cross-correlating MDI and HMI images. The travel-time measurements in the south-north and east-west directions are averaged over the same observation period for the two data sets and then compared to examine the consistency of MDI and HMI travel times after correcting the systematic errors. The offsets in the south-north travel-time difference from MDI data induced by the P-angle error gradually diminish with increasing travel distance. However, these offsets become noisy for travel distances corresponding to waves that reach the base of the convection zone. This suggests that a careful treatment of the P-angle problem is required when studying a deep meridional flow. After correcting the P-angle and the removal of the center-to-limb effect, the travel-time measurements from MDI and HMI are consistent within the error bars for meridional circulation covering the entire convection zone. The fluctuations observed in both data sets are highly correlated and thus indicate their solar origin rather than an instrumental origin. Although our results demonstrate that the ad hoc correction is capable of reducing the wide discrepancy in the travel-time measurements from MDI and HMI, we cannot exclude the possibility that there exist other systematic effects acting on the two data sets in the same way.Comment: accepted for publication in A&

Solar meridional circulation from twenty-one years of SOHO/MDI and SDO/HMI observations: Helioseismic travel times and forward modeling in the ray approximation

The south-north travel-time differences are measured by applying time-distance helioseismology to the MDI and HMI medium-degree Dopplergrams covering May 1996-April 2017. Our data analysis corrects for several sources of systematic effects: P-angle error, surface magnetic field effects, and center-to-limb variations. An interpretation of the travel-time measurements is obtained using a forward-modeling approach in the ray approximation. The travel-time differences are similar in the southern hemisphere for cycles 23 and 24. However, they differ in the northern hemisphere between cycles 23 and 24. Except for cycle 24's northern hemisphere, the measurements favor a single-cell meridional circulation model where the poleward flows persist down to $\sim$0.8 $R_\odot$, accompanied by local inflows toward the activity belts in the near-surface layers. Cycle 24's northern hemisphere is anomalous: travel-time differences are significantly smaller when travel distances are greater than 20$^\circ$. This asymmetry between northern and southern hemispheres during cycle 24 was not present in previous measurements (e.g., Rajaguru & Antia 2015), which assumed a different P-angle error correction where south-north travel-time differences are shifted to zero at the equator for all travel distances. In our measurements, the travel-time differences at the equator are zero for travel distances less than $\sim$30$^\circ$, but they do not vanish for larger travel distances. This equatorial offset for large travel distances need not be interpreted as a deep cross-equator flow; it could be due to the presence of asymmetrical local flows at the surface near the end points of the acoustic ray paths.Comment: accepted for publication in A&

Time-distance helioseismology of solar Rossby waves

Context. Solar Rossby waves (r modes) have recently been discovered in the near-surface horizontal flow field using the techniques of granulation-tracking and ring-diagram analysis applied to six years of SDO/HMI data. Aims. Here we apply time-distance helioseismology to the combined SOHO/MDI and SDO/HMI data sets, which cover 21 years of observations from May 1996 to April 2017. The goal of this study is to provide an independent confirmation over two solar cycles and in deeper layers of the Sun. Methods. We have measured south-north helioseismic travel times along the equator, which are sensitive to subsurface north-south flows. To reduce noise, the travel times were averaged over travel distances from 6$^\circ$ to 30$^\circ$; the mean distance corresponds to a p-mode lower turning point of 0.91 $R_\odot$. The 21-year time series of travel-time measurements was split into three seven-year subsets and transformed to obtain power spectra in a corotating frame. Results. The power spectra all show peaks near the frequencies of the classical sectoral Rossby waves for azimuthal wavenumbers in the range $3 \leq m \leq 15$. The mode frequencies and linewidths of the modes with $m \leq 9$ are consistent with a previous study whereas modes with $m \geq 10$ are shifted toward less negative frequencies by 10--20 nHz. While most of these modes have e-folding lifetimes on the order of a few months, the longest lived mode, $m=3$, has an e-folding lifetime of more than one year. For each mode, the rms velocity at the equator is in the range of 1--3 m s$^{-1}$ , with the largest values for $m\sim10$. No evidence for the $m=2$ sectoral mode is found in the power spectrum, implying that the rms velocity of this mode is below $\sim$0.5 m s$^{-1}$.Comment: accepted for publication in A&

Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends

Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research. However, their ability to en- able cancer precision medicine is limited. Cell culture models cannot retain the genetic and phenotypic heteroge- neity of tumors and lack tumor microenvironment (TME). Patient-derived xenograft mouse models are not suitable for immune-oncology research. While humanized mouse models are time- and cost-consuming. Suitable preclinical models, which can facilitate the understanding of mechanisms of tumor progression and develop new therapeutic strategies, are in high demand. This review article summarizes the recent progress on the establish- ment of TME by using tumor organoid models and microfluidic systems. The main challenges regarding the translation of organoid models from bench to bedside are discussed. The integration of organoids and a microflu- idic platform is the emerging trend in drug screening and precision medicine. A future prospective on this field is also provided.This study was supported by the National Natural Science Foundation of China (Grant No.82073148), the Guangdong Provincial Key Laboratory of Digestive Cancer Research (No. 2021B1212040006), the Sanming Project of Medicine in Shenzhen (SZSM201911010), the Shenzhen Key Medical Discipline Construction Fund (SZXK016), the Shenzhen Sustainable Project (KCXFZ202002011010593), and the Shenzhen-Hong Kong-Macau Technology Research Programme (Type C) (Grant No. SGDX2020110309260100)

The BcB_c Decays to PP-wave Charmonium by Improved Bethe-Salpeter Approach

We re-calculate the exclusive semileptonic and nonleptonic decays of $B_c$ meson to a $P$-wave charmonium in terms of the improved Bethe-Salpeter (B-S) approach, which is developed recently. Here the widths for the exclusive semileptonic and nonleptonic decays, the form factors, and the charged lepton spectrums for the semileptonic decays are precisely calculated. To test the concerned approach by comparing with experimental measurements when the experimental data are available, and to have comparisons with the other approaches the results obtained by the approach and those by some approaches else as well as the original B-S approach, which appeared in literature, are comparatively presented and discussed.Comment: 33 pages, 5 figures, 3 table

Pairing symmetry and properties of iron-based high temperature superconductors

Pairing symmetry is important to indentify the pairing mechanism. The analysis becomes particularly timely and important for the newly discovered iron-based multi-orbital superconductors. From group theory point of view we classified all pairing matrices (in the orbital space) that carry irreducible representations of the system. The quasiparticle gap falls into three categories: full, nodal and gapless. The nodal-gap states show conventional Volovik effect even for on-site pairing. The gapless states are odd in orbital space, have a negative superfluid density and are therefore unstable. In connection to experiments we proposed possible pairing states and implications for the pairing mechanism.Comment: 4 pages, 1 table, 2 figures, polished versio

Scientific Publications in Nephrology and Urology Journals from Chinese Authors in East Asia: A 10-Year Survey of the Literature

BACKGROUND: Diseases of the kidneys and genitourinary tract are common health problems that affect people of all ages and demographic backgrounds. In this study, we compared the quantity and quality of nephrological and urological articles published in international journals from the three major regions of China: the mainland (ML), Hong Kong (HK), and Taiwan (TW). METHODS: Nephrological and urological articles originating from ML, TW, and HK that were published in 61 journals from 1999-2008 were retrieved from the PubMed database. We recorded the numbers of total articles, clinical trials, randomized controlled trials, case reports, impact factors (IF), citations, and articles published in the leading general-medicine journals. We used these data to compare the quantity and quality of publication output from the three regions. RESULTS: The total number of articles increased significantly from 1999 to 2008 in the three regions. The number of articles from ML has exceeded that from HK since 2004, and surpassed that from TW in 2008. Publications from TW had the highest accumulated IF, total citations of articles, and the most articles published in leading general-medicine journals. However, HK publications had the highest average IF. Although ML produced the largest quantity of articles, it exhibited the lowest quality among the three regions. CONCLUSION: The number of nephrological and urological publications originating from the three major regions of China increased significantly from 1999 to 2008. The annual number of publications by ML researchers exceeded those from TW and HK. However, the quality of articles from TW and HK was higher than that from ML

Genome structure and evolutionary history of frankincense producing \u3ci\u3eBoswellia sacra\u3c/i\u3e

Boswellia sacra Flueck (family Burseraceae) tree is wounded to produce frankincense. We report its de novo assembled genome (667.8 Mb) comprising 18,564 high-confidence protein-encoding genes. Comparing conserved single-copy genes across eudicots suggest \u3e97% gene space assembly of B. sacra genome. Evolutionary history shows B. sacra gene-duplications derived from recent paralogous events and retained from ancient hexaploidy shared with other eudicots. The genome indicated a major expansion of Gypsy retroelements in last 2 million years. The B. sacra genetic diversity showed four clades intermixed with a primary genotype—dominating most resin-productive trees. Further, the stemtranscriptome revealed that wounding concurrently activates phytohormones signaling, cell wall fortification, and resin terpenoid biosynthesis pathways leading to the synthesis of boswellic acid—a key chemotaxonomic marker of Boswellia. The sequence datasets reported here will serve as a foundation to investigate the genetic determinants of frankincense and other resin-producing species in Burseraceae

ATOMS : ALMA Three-millimeter Observations of Massive Star-forming regions - I. Survey description and a first look at G9.62+0.19

The ATOMS, standing for ALMA Three-millimeter Observations of Massive Star-forming regions, survey has observed 146 active star-forming regions with ALMA band 3, aiming to systematically investigate the spatial distribution of various dense gas tracers in a large sample of Galactic massive clumps, to study the roles of stellar feedback in star formation, and to characterize filamentary structures inside massive clumps. In this work, the observations, data analysis, and example science of the ATOMS survey are presented, using a case study for the G9.62+0.19 complex. Toward this source, some transitions, commonly assumed to trace dense gas, including CS J = 2-1, HCO+ J = 1-0, and HCN J = 1-0, are found to show extended gas emission in low-density regions within the clump; less than 25 per cent of their emission is from dense cores. SO, CH3OH, (HCN)-C-13, and HC3N show similar morphologies in their spatial distributions and reveal well the dense cores. Widespread narrow SiO emission is present (over similar to 1 pc), which may be caused by slow shocks from large-scale colliding flows or HII regions. Stellar feedback from an expanding HII region has greatly reshaped the natal clump, significantly changed the spatial distribution of gas, and may also account for the sequential high-mass star formation in the G9.62+0.19 complex. The ATOMS survey data can be jointly analysed with other survey data, e.g. MALT90, Orion B, EMPIRE, ALMA IMF, and ALMAGAL, to deepen our understandings of 'dense gas' star formation scaling relations and massive protocluster formation.Peer reviewe