Analysis of acute myocardial infarction occurance in Saratov region using GIS-technologies and prognostic modeling

<p> </p><p><em>The research objective: </em>To find estimation tools of incidence of acute myocardial infarction at the regional level and to optimize organization of medical assistance to patients with acute coronary pathology. <em>Materials. </em>With the use of statistics of territorial distribution of acute myocardial infarction incidence in the region and GIS-TECHNOLOGIES the statistical analysis and mathematical modelling of the spatially-organizational data has been carried out. <em>Results. </em>On the basis of the received results the prognostic model of development of acute coronary pathology has been generated. Measures on optimization of organization of medical assistance to patients with an acute coronary pathology have been stated. <em>Conclusion. </em>Methods of intellectual support of the doctor may become effective in formation of organizational structure of the system of stage-by-stage qualified and specialized aid to patients with acute coronary syndrome.</p&gt

САМОТНІСТЬ У ПІДЛІТКОВОМУ ВІЦІ ЯК СОЦІАЛЬНО-ПСИХОЛОГІЧНА ПРОБЛЕМА

The analysis of the research ?ndings of the contemporary Russian and Ukrainian authors shows  that  there  is  no  consensus  in  interpreting  the  nature  of  loneliness,  its  origin,  speci?c aspects of manifestation in the publications of foreign and native scholars. This allows to outline the problem ?eld of the investigation of loneliness as a social and psychological phenomenon.A teenager acquires social experience in the course of establishing various social relations. The  development  of  individualization,  weakening  of  relationships  with  the  primary  group, intensi?cation of the social mobility within a society and the general instability provoke the growth of the subjective loneliness. The number of teenagers suffering from subjective loneliness grows in the contemporary society. This feeling, as a rule, leads to deviations in behavior and brings about such dangerous consequences as depression, abuse of drugs and alcohol, gambling addiction  and  even  suicide  attempts.  Thus,  loneliness  results  in  serious  problems.  Parental neglect and lack of parental support seem to be the main reasons which stimulate the feelings of loneliness in teenagers. Positive feedback in the families where teenagers experience the lack of parental support is very weak and inadequate, which cause the stagnation of the subsequent socialization of teenagers.Заявлено,  что  чувство  одиночества  в  подростковом  возрасте  является социально-психологической  проблемой.  Проанализированы  разные  точки  зрения ученых на данный феномен в этом возрасте. Раскрыты основные психологические особенности личности подросткового возраста и обосновывается их влияние на проявление одиночества. Показано, как психологически влияют проявления одиночества на социальные связи подростка с окружающими и социализацию в целом с учетом того, что в этом возрасте подросток особенно остро нуждается в принятии и признании себя как личности окружающими.Заявлено, що почуття самотності у підлітковому віці є соціально-психологічною проблемою. Проаналізовано різні точки зору вчених на даний феномен у цьому віці. Розкрито основні психологічні особливості особистості підліткового віку і обгрунтовано їх вплив на прояви самотності. Показано, як психологічно впливають прояви самотності на соціальні зв’язки підлітка з оточуючими і соціалізацію в цілому, враховуючи те, що у цьому віці підліток особливо гостро потребує прийняття та визнання себе як особистості оточуючими

Obesity as unfavorable background of asthma

Asthma accompanied by increased of content of proinflam- matory cytokines TNF-α (2.6 fold) and IL-6 of (1.4 times), while the comor- bidity of asthma and obesity worsens the revealed violations (an increase of 3.7 and 1.9 times, respectively), which can be considered as a negative factor supporting the inflammatory process in bronchopulmonary system

The Limits of Lawyering: Legal Opinions in Structured Finance

Significant controversy surrounds the issuance of legal opinions in structured finance transactions, particularly where accountants separately use these opinions, beyond their traditional primary use, for determining whether to characterize the transactions as debt. Reflecting at its core the unresolved boundaries between public and private in financial transactions, this controversy raises important issues of first impression: To what extent, for example, should lawyers be able to issue legal opinions that create negative externalities? Furthermore, what should differentiate the roles of lawyers and accountants in disclosing information to investors? Resolution of these issues not only helps to demystify the mystique, and untangle the morass, of legal-opinion giving but also affects the very viability of the securitization industry, which dominates American, and increasingly global, financing

Calcium homeostasis changes in patients with chronic colitis and arterial hypertension

In patients with chronic colitis and hypertension observed negative dynamics of calcium homeostasis. It is therefore appropriate to include calcium in the complex treatment of drugs for the prevention or correction osteopenic conditions and osteoporosis

Youth in the Space of Actual Culture: Dynamics of Value Orientations

The article discusses the relationship of the cultural landmarks of youth with the dynamics of the cultural transformation of society and determines the contradictions of the processes of the formation of cultural requests and the needs of youth. The article analyzes the tendencies and features of the current stage of development of society from the point of view of actual culture and presents statistical data that illustrates proposed theses.В статье рассматриваются вопросы взаимосвязи культурных ориентиров молодежи с динамикой культурной трансформации общества. Определены противоречия процессов формирования культурных запросов и потребностей молодежи. Проанализированы тенденции и особенности нынешнего этапа развития общества с точки зрения актуальной культуры. Приведены статистические данные, иллюстрирующие выдвинутые тезисы

EFFICACY OF FIXED COMBINATION OF VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE IN COMPLEX THERAPY OF THE PATIENT OF VERY HIGH CARDIOVASCULAR RISK

The high prevalence of arterial hypertension in association with high and very high cardiovascular risk requires widespread use of combined therapy. Current approaches to selection of combination components of antihypertensive drugs are based the efficacy of these drugs proven in multicenter randomized clinical trials. The triple combination of calcium antagonist, angiotensin II receptor blocker and thiazide diuretic is regarded as the best option for combined therapy in patients with arterial hypertension and ischemic heart disease to reduce cardiovascular risk

Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021

BACKGROUND. One of the priority directions in the development of the health care system is to reduce the medical and social damage caused by the increase in the prevalence of diabetes mellitus (DM). From this point of view, the development of a diabetes register is very important as the main information and analytical platform for clinical and epidemiological monitoring of diabetes in the Russian Federation (RF).AIMS. The aim of our study was to analyze a dynamic (2016–2020) of the epidemiological characteristics of diabetes mellitus in the Russian Federation (prevalence, morbidity, mortality), the prevalence of complications, the level of HbA1c and the dynamics of the structure of glucose-lowering therapy (GLT) according to the Federal Diabetes Register (FDR).MATERIALS AND METHODs. The database of FRD (http://diaregistry.ru) 84 regions of the RF. The data are presented in dynamics 2016→2020.RESULTS. The total number of DM patients in the RF as of 01.01.2021 was 4,799,552 (3.23% of the population), including: Type 1 (T1) — 5.5% (265.4 ths) , T2 — 92.5% (4.43 million), other DM types — 2.0% (99.3 ths). The dynamics of prevalence was 168.7→180.9/100 ths people with T1, and 2709 → 3022/100 ths people with T2; morbidity in T1 10.5→7.7/100 ths population, in T2 219.6→154.2/100 ths population. Age and sex characteristics: the proportion of men in T1 — 54%, in T2 — 30%; the max proportion of patients with T1 at the age of 30–39 years, T2 65–69 years. Mortality: T1 3.0 → 2.7/100 ths population, T2 87.7→93.9/100 ths of the population, the main cause of death was cardiovascular: in T1 38,1% cases, in T2 — 52,0%. Life expectancy (average age of death of patients): T1 was 53.2years, the dynamics in males 50.7 → 50.5years, ­females 58.7→55.2years; in T2 — 73.5 years, males 70.2→70.1years, females 75.7→75.4 years. The dynamic of DM duration until the death: in T1 17.4→19.0 years; in T2 11→11.4 years. The incidence of diabetic complications in T1 and T2 patients: neuropathy 43.3% and 24.4%, nephropathy (CKD) 25.9% and 18.4%, retinopathy 31.7% and 13.5%, respectively. The ­proportion of ­patients with HbA1c <7%: in T1 32.3%→36.9%, in T2 51.9%→52.1%, with HbA1c ≥ 9.0% in T1 23.1%→18.7% , in T2 8.9%→8.0%. The structure GLT in T2 patients: glucose lowering medications (GLM) — 76.2% (monotherapy — 44.1%; ­combination of  2 GLM — 28.9%, 3 GLM — 3.2%), insulin therapy in 18,8%, without drug therapy in 4.9%.CONCLUSIONS. The performed analysis demonstrates the importance of dynamic assessment of epidemiological characteristics and monitoring of clinical data on patients with diabetes through a registry for assessing the quality of diabetes care and the prospects for its development

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

Background: The mechanisms by which genetic variants, such as single nucleotide polymorphisms (SNPs), identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to the epigenetic and chromatin states of the genome as having important roles. Methods: We genotyped 355 healthy young individuals for 52 known obesity-associated SNPs and obtained DNA methylation levels in their blood using the Illumina 450 K BeadChip. Associations between alleles and methylation at proximal cytosine residues were tested using a linear model adjusted for age, sex, weight category, and a proxy for blood cell type counts. For replication in other tissues, we used two open-access datasets (skin fibroblasts, n = 62; four brain regions, n = 121-133) and an additional dataset in subcutaneous and visceral fat (n = 149). Results: We found that alleles at 28 of these obesity-associated SNPs associate with methylation levels at 107 proximal CpG sites. Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27). Interestingly, the associated SNPs are in known eQTLs for some of these genes. We also found that the 107 CpGs are enriched in enhancers in peripheral blood mononuclear cells. Finally, our results indicate that some of these associations are not blood-specific as we successfully replicated four associations in skin fibroblasts. Conclusions: Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated with human diseases and traits