Minkowski Brane in Asymptotic dS5_5 Spacetime without Fine-tuning

We discuss properties of a 3-brane in an asymptotic 5-dimensional de-Sitter spacetime. It is found that a Minkowski solution can be obtained without fine-tuning. In the model, the tiny observed positive cosmological constant is interpreted as a curvature of 5-dimensional manifold, but the Minkowski spacetime, where we live, is a natural 3-brane perpendicular to the fifth coordinate axis.Comment: 6 pages, Latex fil

Research on Assessment Method of Fire Protection System

AbstractSafety assessment of fire protection (SAFP) is a very important approach in fire safety management. Effectiveness and reliability are crucial to the SAFP, which has endowed the study of the assessment methods significant meaning. A new quantitative method named theoretical safety control method, based on modern control theory, was studied in the paper. Dynamic models, assessment indexes and analysis approaches of every index of the SAFP were put forward and three dynamic indexes, that are System Hazard Index-H, Control Capacity Index-C and Safety Degree-S which changed with the system states and presented the conflicting consequence between hazards and controlling of fire protection system, were used to evaluate the results of the method. This method can realize dynamic and quantitative management and the fire protection system controlling. A case study was defined and assessed by using the method in this paper, and the results of evaluation were viable compared with the actual situation

Vacuum Energy Density and Cosmological Constant in dS Brane World

We discuss the vacuum energy density and the cosmological constant of dS$_5$ brane world with a dilaton field. It is shown that a stable AdS$_4$ brane can be constructed and gravity localization can be realized. An explicit relation between the dS bulk cosmological constant and the brane cosmological constant is obtained. The discrete mass spectrum of the massive scalar field in the AdS$_4$ brane is used to acquire the relationship between the brane cosmological constant and the vacuum energy density. The vacuum energy density in the brane gotten by this method is in agreement with astronomical observations.Comment: 16 pages,4 figure

Predictive metabolites for incident myocardial infarction:a two-step meta-analysis of individual patient data from six cohorts comprising 7,897 individuals from the the COnsortium of METabolomic Studies

Aims: Myocardial infarction (MI) is a major cause of death and disability worldwide. Most metabolomics studies investigating metabolites predicting MI are limited by the participant number and/or the demographic diversity. We sought to identify biomarkers of incident MI in the COnsortium of METabolomics Studies. Methods and results: We included 7897 individuals aged on average 66 years from six intercontinental cohorts with blood metabolomic profiling (n = 1428 metabolites, of which 168 were present in at least three cohorts with over 80% prevalence) and MI information (1373 cases). We performed a two-stage individual patient data meta-analysis. We first assessed the associations between circulating metabolites and incident MI for each cohort adjusting for traditional risk factors and then performed a fixed effect inverse variance meta-analysis to pull the results together. Finally, we conducted a pathway enrichment analysis to identify potential pathways linked to MI. On meta-analysis, 56 metabolites including 21 lipids and 17 amino acids were associated with incident MI after adjusting for multiple testing (false discovery rate < 0.05), and 10 were novel. The largest increased risk was observed for the carbohydrate mannitol/sorbitol {hazard ratio [HR] [95% confidence interval (CI)] = 1.40 [1.26-1.56], P < 0.001}, whereas the largest decrease in risk was found for glutamine [HR (95% CI) = 0.74 (0.67-0.82), P < 0.001]. Moreover, the identified metabolites were significantly enriched (corrected P < 0.05) in pathways previously linked with cardiovascular diseases, including aminoacyl-tRNA biosynthesis. Conclusions: In the most comprehensive metabolomic study of incident MI to date, 10 novel metabolites were associated with MI. Metabolite profiles might help to identify high-risk individuals before disease onset. Further research is needed to fully understand the mechanisms of action and elaborate pathway findings.This research was funded in whole, or in part, by the Wellcome Trust (WT212904/Z/18/Z) and by the UKRI Medical Research Council (MRC)/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (AIM-HY; MR/M016560/1). For the purpose of open access, the authors have applied a CC BY public copyright to any author-accepted manuscript version arising from this submission. TwinsUK receives funding from the Wellcome Trust, the European Commission H2020 grants SYSCID (contract #733100), the National Institute for Health Research (NIHR) Clinical Research Facility and the Biomedical Research Centre based at Guy's and St Thomas’ NHS Foundation Trust in partnership with King's College London, the Chronic Disease Research Foundation, the UKRI Medical Research Council (MRC)/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (AIM-HY; MR/M016560/1), and Zoe Limited. C.M. and A.N. are funded by the Chronic Disease Research Foundation. C.M. is also funded by the MRC AIM-HY grant. The Atherosclerosis Risk in Communities (ARIC) study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, and 75N92022D00005). The authors thank the staff and participants of the ARIC study for their important contributions). B.Y. was in part supported by R01HL168683. Metabolomics measurements were sponsored by the National Human Genome Research Institute (3U01HG004402-02S1). The ET2DS was funded by the Medical Research Council (UK) (Project Grant G0500877) and the Chief Scientist Office of Scotland (Program Support Grand CZQ/1/38). C.B. was funded by the grant FIS-FEDER-ISCIII PI16/00620 (Ext 2021) and the Strategic Plan for Research and Innovation in Health, CatSalut, PERIS STL008 (2019–2021), and RICORS RD21/0005, to develop clinical and epidemiological studies mainly focused on diabetes and its associations with new biomarkers. HABC was supported in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging (NIA); contracts: N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106; NIA grant: R01-AG028050, and NINR grant R01-NR012459; and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR000454. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr Murphy is supported by the Michael Smith Foundation for Health Research (grant #17644). The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. The authors thank the WHI investigators and staff for their dedication and the study participants for making the program possible. A full listing of WHI investigators can be found at https://www-whi-org.s3.us-west-2.amazonaws.com/wp-content/uploads/WHI-Investigator-Long-List.pdf

Emergence of Quantum Confinement in Topological Kagome Superconductor CsV3_3Sb5_5 family

Quantum confinement is a restriction on the motion of electrons in a material to specific region, resulting in discrete energy levels rather than continuous energy bands. In certain materials quantum confinement could dramatically reshape the electronic structure and properties of the surface with respect to the bulk. Here, in the recently discovered kagome superconductor CsV$_3$Sb$_5$ (A=K, Rb, Cs) family of materials, we unveil the dominant role of quantum confinement in determining their surface electronic structure. Combining angle-resolved photoemission spectroscopy (ARPES) measurement and density-functional theory simulation, we report the observations of two-dimensional quantum well states due to the confinement of bulk electron pocket and Dirac cone to the nearly isolated surface layer. The theoretical calculations on the slab model also suggest that the ARPES observed spectra are almost entirely contributed by the top two layers. Our results not only explain the disagreement of band structures between the recent experiments and calculations, but also suggest an equally important role played by quantum confinement, together with strong correlation and band topology, in shaping the electronic properties of this family of materials

The Role of Receptor for Advanced Glycation End Products (RAGE) in the Proliferation of Hepatocellular Carcinoma

The receptor for advanced glycation end products (RAGE) is oncogenic and overexpressed in human cancers, but its role in hepatocellular carcinoma remains unclear. Here we demonstrated that RAGE is overexpressed in primary hepatocellular carcinoma (PHC) compared to adjacent para-neoplastic liver samples. Serum endogenous secretory RAGE levels were also increased in PHC patients (p < 0.01). Moreover, we demonstrated that RAGE regulates cellular proliferation in Hepatocellular carcinoma (HCC). Knockdown of RAGE by specific siRNA inhibited cellular growth in the hepatocellular carcinoma cell line, Huh7, whereas the RAGE ligand, high mobility group box 1 protein (HMGB1) increased cellular proliferation. In addition, knockdown of RAGE by siRNA arrested cells in the G1 phase and inhibited DNA synthesis (p < 0.01), while HMGB1 protein decreased the number of cells in the G1 phase and increased the number in the S phase (p < 0.05). Furthermore, quantitative real time RT-PCR (qRT-PCR) and Western Blot results demonstrated that RAGE and HMGB1 positively regulate NF-κB p65 expression in Huh7 cells. These studies suggest that RAGE and RAGE ligands are important targets for therapeutic intervention in hepatocellular carcinoma