Life-Logging Data Aggregation Solution for Interdisciplinary Healthcare Research and Collaboration

The wide-spread use of wearable devices and mobile apps in the Internet of Things (IoT) environments makes effectively capture of life-logging personal health data come true. A long-term collection of these health data will benefit to interdisciplinary healthcare research and collaboration. But most wearable devices and mobile apps in the market focus on personal fitness plan and lack of compatibility and extensibility to each other. Existing IoT based platforms rarely achieve a successful heterogeneous life-logging data aggregation. Also, the demand on high security increases difficulties of designing reliable platform for integrating and managing multi-resource life-logging health data. This paper investigates the possibility of collecting and aggregating life-logging data with the use of wearable devices, mobile apps and social media. It compares existing personal health data collection solutions and identifies essential needs of designing a life-logging data aggregator in the IoT environments. An integrated data collection solution with high secure standard is proposed and deployed on a state-of-the-art interdisciplinary healthcare platform: MHA [15] by integrating five life-logging resources: Fitbit, Moves, Facbook, Twitter, etc. The preliminary experiment demonstrates that it successfully record, store and reuse the unified and structured personal health information in a long term, including activities, location, exercise, sleep, food, heat rate and mood

Effect of dc bias on the Curie-Weiss exponent in 0.76Pb(Mg[sub ⅓]Nb[sub ⅔]) O₃-0.24PbTiO₃ ferroelectric single crystal

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

10Be和26Ai揭示的合黎山西南部侵蚀速率初步研究

地表侵蚀速率是衡量地貌演化的一个重要因子。本研究利用原地宇宙成因核素 10Be 和 26Al 对合黎山西南部地表岩石侵蚀速率进行了首次测定。结果显示：约 30 ka 以来，合黎山西南部的地表岩石侵速率约为 24 mm∙ka-1。这一结果与已见报道的其他基岩侵蚀速率值一致。这一结果与 Small et al 获得的非干旱地区的基岩侵蚀速率也基本一致，但是显著高于干旱的南极地区和半干旱的澳大利亚。10Be 和26Al 获得的侵蚀速率的良好一致性表明本研究中所用侵蚀模式的有效性。所得的侵蚀速率小于 Palumbo et al 测定的合黎山平均流域侵蚀速率（99 mm∙ka-1），原因解释尚待更多地点和样品的研究。<br style="line-height: normal; text-align: -webkit-auto; text-size-adjust: auto;" /

Species composition, plant cover and diversity of recently reforested wild lands near Dabao Highway in Longitudinal Range-Gorge Region of Yunnan Province, China

Deforestation, over-cultivation and rural growth have severely damaged native vegetation of woodlands along roadsides in the Longitudinal Range-Gorge Region of Yunnan Province. This study wasconducted to evaluate the effect of different reforestation practices, which consisted of natural restoration or planting with tree seedlings that varied in species composition, coverage and diversity,on damaged roadside woodlands. Three randomly selected 10 m x 10 m plots in each reforestation practice were investigated. The results showed that the species composition, plant cover and speciesdiversity of the planted communities varied with reforestation strategies and time since planting. A higher number of species, proportion of native species and woody plants, canopy cover and speciesdiversity were found in naturally restored plots and in 3 - 4 year old plots that were planted with native plants. In the early stages of reforestation, herbs dominated the plant community in most plots, andwoody plants became more important with time after reforestation. Preliminary results suggest that plant height can be used an auxiliary indicator of plant cover to assess ecosystem function status ofthe restoration project. Also, evenness may be easier to restore than species richness. Natural restoration or reforestation with native dominant plants is a good management strategy for vegetationrestoration or improvement

Viral integration drives multifocal HCC during the occult HBV infection

© 2019 The Author(s). Background & Aims: Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the mechanism of life-long Integration of virus DNA into OBI host's genome, of which may induce hepatocyte transformation. Methods: We applied HBV capture sequencing on single cells from an OBI patient who, developed multiple HCC tumors and underwent liver resection in May 2013 at Tongji Hospital in China. Despite with the undetectable virus DNA in serum, we determined the pattern of viral integration in tumor cells and adjacent non-tumor cells and obtained the details of the viral arrangement in host genome, and furthermore the HBV integrated region in cancer genome. Results: HBV captured sequencing of tissues and individual cells revealed that samples from multiple tumors shared two viral integration sites that could affect three host genes, including CSMD2 on chr1 and MED30/EXT1 on chr8. Whole genome sequencing further indicated one hybrid chromosome formed by HBV integrations between chr1 and chr8 that was shared by multiple tumors. Additional 50 poorly differentiated liver tumors and the paired adjacent non-tumors were evaluated and functional studies suggested up-regulated EXT1 expression promoted HCC growth. We further observed that the most somatic mutations within the tumor cell genome were common among the multiple tumors, suggesting that HBV associated, multifocal HCC is monoclonal in origin. Conclusion: Through analyzing the HBV integration sites in multifocal HCC, our data suggested that the tumor cells were monoclonal in origin and formed in the absence of active viral replication, whereas the affected host genes may subsequently contribute to carcinogenesis

Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid

Coaxial electrospraying was explored to organize polymer excipients in a core-shell manner for providing biphasic controlled release of active ingredient. With ferulic acid (FA) as a model drug, and shellac and polyvinylpyrrolidone (PVP) as the core and shell polymeric matrices, core-shell nanoparticles were successfully fabricated. A series of tests were carried out to characterize the prepared core-shell nanoparticles and also the nanoparticles prepared using a single fluid electrospraying of the shell or core fluids alone. The core-shell nanoparticles had an average diameter of 530 ± 80 nm with clear core-shell structure. The contained FA was converted to an amorphous state both in the core and the shell parts due to the favorable hydrogen bonding between the components. In vitro dissolution tests demonstrated that the core-shell nanoparticles were able to provide the desired biphasic drug-controlled release profiles. Coaxial electrospraying is a useful tool for the development of novel nanodrug delivery systems from polymers

Structure and Photoluminescent Properties of ZnO Encapsulated in Mesoporous Silica SBA-15 Fabricated by Two-Solvent Strategy

The two-solvent method was employed to prepare ZnO encapsulated in mesoporous silica (ZnO/SBA-15). The prepared ZnO/SBA-15 samples have been studied by X-ray diffraction, transmission electron microscope, X-ray photoelectron spectroscopy, nitrogen adsorption–desorption isotherm, and photoluminescence spectroscopy. The ZnO/SBA-15 nanocomposite has the ordered hexagonal mesostructure of SBA-15. ZnO clusters of a high loading are distributed in the channels of SBA-15. Photoluminescence spectra show the UV emission band around 368 nm, the violet emission around 420 nm, and the blue emission around 457 nm. The UV emission is attributed to band-edge emission of ZnO. The violet emission results from the oxygen vacancies on the ZnO–SiO2interface traps. The blue emission is from the oxygen vacancies or interstitial zinc ions of ZnO. The UV emission and blue emission show a blue-shift phenomenon due to quantum-confinement-induced energy gap enhancement of ZnO clusters. The ZnO clusters encapsulated in SBA-15 can be used as light-emitting diodes and ultraviolet nanolasers

Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial)

Background: Pre- and postconditioning describe mechanisms whereby short ischemic periods protect an organ against a longer period of ischemia. Interestingly, short ischemic periods of a limb, in itself harmless, may increase the ischemia tolerance of remote organs, e.g. the heart (remote conditioning, RC). Although several studies have shown reduced biomarker release by RC, a reduction of complications and improvement of patient outcome still has to be demonstrated. Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass graft surgery (CABG), affecting 27-46% of patients. It is associated with increased mortality, adverse cardiovascular events, and prolonged in-hospital stay. We hypothesize that remote ischemic pre- and/or post-conditioning reduce the incidence of AF following CABG, and improve patient outcome.Methods/design: This study is a randomized, controlled, patient and investigator blinded multicenter trial. Elective CABG patients are randomized to one of the following four groups: 1) control, 2) remote ischemic preconditioning, 3) remote ischemic postconditioning, or 4) remote ischemic pre- and postconditioning. Remote conditio

Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis.

BACKGROUND: Sexually transmitted infections (STIs), including Hepatitis B and C virus, are emerging public health risks in China, especially among men who have sex with men (MSM). This study aims to assess the magnitude and risks of STIs among Chinese MSM. METHODS: Chinese and English peer-reviewed articles were searched in five electronic databases from January 2000 to February 2013. Pooled prevalence estimates for each STI infection were calculated using meta-analysis. Infection risks of STIs in MSM, HIV-positive MSM and male sex workers (MSW) were obtained. This review followed the PRISMA guidelines and was registered in PROSPERO. RESULTS: Eighty-eight articles (11 in English and 77 in Chinese) investigating 35,203 MSM in 28 provinces were included in this review. The prevalence levels of STIs among MSM were 6.3% (95% CI: 3.5-11.0%) for chlamydia, 1.5% (0.7-2.9%) for genital wart, 1.9% (1.3-2.7%) for gonorrhoea, 8.9% (7.8-10.2%) for hepatitis B (HBV), 1.2% (1.0-1.6%) for hepatitis C (HCV), 66.3% (57.4-74.1%) for human papillomavirus (HPV), 10.6% (6.2-17.6%) for herpes simplex virus (HSV-2) and 4.3% (3.2-5.8%) for Ureaplasma urealyticum. HIV-positive MSM have consistently higher odds of all these infections than the broader MSM population. As a subgroup of MSM, MSW were 2.5 (1.4-4.7), 5.7 (2.7-12.3), and 2.2 (1.4-3.7) times more likely to be infected with chlamydia, gonorrhoea and HCV than the broader MSM population, respectively. CONCLUSION: Prevalence levels of STIs among MSW were significantly higher than the broader MSM population. Co-infection of HIV and STIs were prevalent among Chinese MSM. Integration of HIV and STIs healthcare and surveillance systems is essential in providing effective HIV/STIs preventive measures and treatments. TRIAL REGISTRATION: PROSPERO NO: CRD42013003721