61,238 research outputs found
Classification of extremal elliptic K3 surfaces and fundamental groups of open K3 surfaces
We present a complete list of extremal elliptic K3 surfaces. There are
altogether 325 of them. The first 112 coincides with Miranda-Persson's list for
semi-stable ones. The data include the transcendental lattice which determines
uniquely the K3 surface by a result of Shioda and Inose, the singular fibre
type and the Mordell Weil group. As an application, we give a sufficient
condition for the topological fundamental group of complement to an
ADE-configuration of smooth rational curves on a K3 surface to be trivial.Comment: 25 pages, Nagoya Math. J. to appea
Knowledge discovery for friction stir welding via data driven approaches: Part 2 – multiobjective modelling using fuzzy rule based systems
In this final part of this extensive study, a new systematic data-driven fuzzy modelling approach has been developed, taking into account both the modelling accuracy and its interpretability (transparency) as attributes. For the first time, a data-driven modelling framework has been proposed designed and implemented in order to model the intricate FSW behaviours relating to AA5083 aluminium alloy, consisting of the grain size, mechanical properties, as well as internal process properties. As a result, ‘Pareto-optimal’ predictive models have been successfully elicited which, through validations on real data for the aluminium alloy AA5083, have been shown to be accurate, transparent and generic despite the conservative number of data points used for model training and testing. Compared with analytically based methods, the proposed data-driven modelling approach provides a more effective way to construct prediction models for FSW when there is an apparent lack of fundamental process knowledge
On the Impact of Multiobjective Scalarizing Functions
Recently, there has been a renewed interest in decomposition-based approaches
for evolutionary multiobjective optimization. However, the impact of the choice
of the underlying scalarizing function(s) is still far from being well
understood. In this paper, we investigate the behavior of different scalarizing
functions and their parameters. We thereby abstract firstly from any specific
algorithm and only consider the difficulty of the single scalarized problems in
terms of the search ability of a (1+lambda)-EA on biobjective NK-landscapes.
Secondly, combining the outcomes of independent single-objective runs allows
for more general statements on set-based performance measures. Finally, we
investigate the correlation between the opening angle of the scalarizing
function's underlying contour lines and the position of the final solution in
the objective space. Our analysis is of fundamental nature and sheds more light
on the key characteristics of multiobjective scalarizing functions.Comment: appears in Parallel Problem Solving from Nature - PPSN XIII,
Ljubljana : Slovenia (2014
Study of Proton Magic Even-Even Isotopes and Giant Halos of Ca Isotopes with Relativistic Continuum Hartree-Bogoliubov Theory
We study the proton magic O, Ca, Ni, Zr, Sn, and Pb isotope chains from the
proton drip line to the neutron drip line with the relativistic continuum
Hartree-Bogoliubov (RCHB) theory. Particulary, we study in detail the
properties of even-even Ca isotopes due to the appearance of giant halos in
neutron rich Ca nuclei near the neutron drip line. The RCHB theory is able to
reproduce the experimental binding energies and two neutron separation
energies very well. The predicted neutron drip line nuclei are
O, Ca, Ni, Zr, Sn, and Pb,
respectively. Halo and giant halo properties predicted in Ca isotopes with
are investigated in detail from the analysis of two neutron separation
energies, nucleon density distributions, single particle energy levels, the
occupation probabilities of energy levels including continuum states. The
spin-orbit splitting and the diffuseness of nuclear potential in these Ca
isotopes are studied also. Furthermore, we study the neighboring lighter
isotopes in the drip line Ca region and find some possibility of giant halo
nuclei in the Ne-Na-Mg drip line nuclei.Comment: 45 pages, 20 figure
Multi-boson effects and the normalization of the two-pion correlation function
The two-pion correlation function can be defined as a ratio of either the
measured momentum distributions or the normalized momentum space probabilities.
We show that the first alternative avoids certain ambiguities since then the
normalization of the two-pion correlator contains important information on the
multiplicity distribution of the event ensemble which is lost in the second
alternative. We illustrate this explicitly for specific classes of event
ensembles.Comment: 6 pages, three figures,submit to PR
Mapping linked quantitative trait loci via residual maximum likelihood
International audienc
Identification of a novel TSC2 c.3610G > A, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in
any organ systems. Mutations in the TSC1 or TSC2 gene lead to the dysfunction of hamartin or tuberin proteins,
which cause tuberous sclerosis complex.
Case presentation: We describe the clinical characteristics of patients from a Chinese family with tuberous sclerosis
complex and analyze the functional consequences of their causal genetic mutations. A novel heterozygous mutation
(c.3610G > A) at the last nucleotide of exon 29 in TSC2 was identified. On the protein level, this variant was presumed
to be a missense mutation (p.Gly1204Arg). However, the splicing assay revealed that this mutation also leads to the
whole TSC2 exon 29 skipping, besides the wild-type transcript. The mutated transcript results in an in-frame deletion of
71 amino acids (p.Gly1133_Thr1203del) and its ratio with the normal splice product is of about 44:56.
Conclusions: The novel c.3610G > A TSC2 mutation was identified in association with tuberous sclerosis complex. And
it was proven to code both for a missense-carrying transcript (56%), and for an isoform lacking exon 29 (44%)
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