S100B brain expression and plasma concentrations in a preeclampsia rat model

Objective: To assess brain damage using the neuroinflammation marker S100B in a preeclampsia rat model.Methods: Non-pregnant and pregnant rats were infused with saline or low-dose-endotoxin on day 14 of pregnancy. S100B expression in the brain (immunohistochemistry) and S100B plasma concentrations (ELISA) were studied.Results: No differences in S100B expression in brain tissue were observed between the four groups. Pregnant endotoxin treated animals did not show increased levels of plasma S100B levels as compared with control pregnant rats, while significantly higher plasma S100B levels were found in non-pregnant endotoxin versus pregnant endotoxin infused rats.Conclusion: Pregnancy nor experimental preeclampsia, alter S100B in rat brain, or in plasma. Increased plasma S100B in non-pregnant endotoxin-treated rats may indicate brain injury in these rats, whereas pregnancy might be protective.</p

Oestrogen removal from biological pretreated wastewater within decentralized sanitation and re-use concepts

Two parallel researches were performed; one focused on the fate of oestrogens in the biological treatment systems within decentralised sanitation and re-use concepts (DESAR), the second related to the development of a suitable specific removal method. A new affinity membrane was developed using antibodies as specific binding sites for hormone removal. It was found that, especially in anaerobic treatment, the core technology in DESAR, the removal is insufficient and therefore an additional separation method is required. The affinity membrane with antibodies was found to be a suitable additional method, though in the current system it only removes one selected compound. Future research will focus on making this method more feasible in practis

Cerebral white matter lesions and perceived cognitive dysfunction: the role of pregnancy

ObjectiveWomen who suffered eclampsia or preterm preeclampsia are twice as likely to demonstrate cerebral white matter lesions (WML) on magnetic resonance imaging compared with age-matched women who had normotensive pregnancies, and they report more cognitive dysfunctions in everyday life. We aimed to determine whether pregnancy in and of itself has a relationship with the presence of WML and subjective cognitive dysfunction.Study DesignEighty-one parous women who had a normotensive pregnancy were matched for age with 65 nulliparous women and all underwent cerebral magnetic resonance imaging. Presence of cerebral WML was rated and blood pressure was measured. Subjective cognitive functioning was assessed using the Cognitive Failures Questionnaire.ResultsThere was no difference in the presence (22% vs 19%) of WML between parous and nulliparous women. Age was a predictor for the presence of WML, whereas the presence of current hypertension was not. Average score on the Cognitive Failures Questionnaire was not different between both groups, nor related to WML.ConclusionA history of pregnancy in and of itself is not related to the presence of cerebral WML and the perception of cognitive dysfunction. Because of the relationship with preterm preeclampsia and eclampsia, future research should focus on the clinical importance and development throughout the years of such cerebral WML in young women and focus on risk factors for cardiovascular disease

Relativistic Effects of Light in Moving Media with Extremely Low Group Velocity

A moving dielectric medium acts as an effective gravitational field on light. One can use media with extremely low group velocities [Lene Vestergaard Hau et al., Nature 397, 594 (1999)] to create dielectric analogs of astronomical effects on Earth. In particular, a vortex flow imprints a long-ranging topological effect on incident light and can behave like an optical black hole.Comment: Physical Review Letters (accepted

Cerebral white matter lesions, subjective cognitive failures, and objective neurocognitive functioning:A follow-up study in women after hypertensive disorders of pregnancy

OBJECTIVE: Hypertensive disorders of pregnancy, like preeclampsia, are a leading cause of maternal and fetal morbidity/mortality worldwide. Preeclampsia can be complicated by the occurrence of convulsions (eclampsia). Women who experienced (pre)eclampsia more frequently report daily cognitive failures and showed increased emotional dysfunction several years later, but are not impaired on objective neurocognitive testing. In addition, women with preterm preeclampsia more often have cerebral white matter lesions (WML) on follow-up. We aimed to determine whether WML presence is related to cognitive dysfunction, anxiety, and depressive symptoms in (pre)eclamptic women. METHOD: Forty-one eclamptic, 49 preeclamptic, and 47 control women who had a normotensive pregnancy completed the Cognitive Failures Questionnaire (CFQ), the Hospital Anxiety and Depression Scale (HADS), and a broad neurocognitive test battery (visual perception and speed of information processing, motor functions, working memory, long-term memory, attention, and executive functioning). All underwent cerebral magnetic resonance imaging (MRI), and WML presence was recorded. Median elapsed time since index pregnancy was 6 years. Average age was 40 years. RESULTS: WML were more prevalent in women who had experienced preterm (pre)eclampsia (<37 weeks; 40%) than in controls (21%, p = .03). In (pre)eclamptic women, CFQ and HADS scores were higher than those in controls (44± 16.1 vs. 36± 11.0, p < .001, and 11± 6.3 vs. 8± 5.5, p < .001). There was no difference in objective cognitive performance as measured by neurocognitive tests. Subjective and objective cognitive functioning, anxiety, and depressive symptoms were not related to WML presence. CONCLUSION: Formerly (pre)eclamptic women report cognitive dysfunction, but do not exhibit overt cognitive impairment when objectively tested on average 6 years following their pregnancy. The presence of WML is not related to objective nor to subjective cognitive impairment, anxiety, and depressive symptoms. Longitudinal studies are needed to study whether the presence of WML is a risk factor for developing objective cognitive impairment in the long term

Long-Term Visual Functioning After Eclampsia

OBJECTIVE: Complete neurocognitive recovery after eclampsia has been questioned with the expression of neurocognitive deficits by affected women and demonstration of cerebral white matter lesions on magnetic resonance imaging years after eclampsia. We hypothesized that formerly eclamptic women may experience impaired vision-related quality of life (QOL) and visual field loss as a result of the presence of such lesions in the cerebral visual areas. METHODS: Using the National Eye Institute Visual Function Questionnaire-39/Nederlands questionnaire, vision-related QOL was compared between formerly eclamptic women and control participants after normotensive pregnancies. Furthermore, in formerly eclamptic women, visual fields were assessed using automated perimetry, and presence of white matter lesions was evaluated using cerebral magnetic resonance imaging. Presence of a relationship between these lesions and National Eye Institute Visual Function Questionnaire-39/Nederlands scores was estimated. RESULTS: Forty-seven formerly eclamptic women and 47 control participants participated 10.1 +/- 5.2 and 11.5 +/- 7.8 years after their index pregnancy, respectively. Composite scores and 4 out of 12 National Eye Institute Visual Function Questionnaire-39/Nederlands subscale scores were significantly lower in formerly eclamptic women than in control participants (P CONCLUSION: Formerly eclamptic women express lower vision-related QOL than control participants, which seemed at least partly related to the presence of white matter lesions. However, such women do not have unconscious visual field loss. Vision-related QOL impairment expressed by formerly eclamptic women may therefore be related to problems with higher-order visual functions

Montane ecosystem productivity responds more to global circulation patterns than climatic trends

Ajuts: we thank the support of KIT IMK-IFU, the University of Wisconsin sabbatical leave program, and the Helmholtz Society/MICMOR fellowship program. We also thank the DWD for German weather data. Phenology data were provided by the members of the PEP725 project. We are indebted to the providers and funders of the eddy covariance flux tower observations, the FLUXNET program, and its database. The sites in Graswang, Rottenbuch and Fendt belong to the TERENO and ICOS-ecosystems networks, funded by Bundesministerium für Bildung und Forschung(BMBF)and the Helmholtz Association. The modeling study of SOLVEG was partially supported by Grant-in-Aid for Scientific Research, no. 21120512, provided by the Japan Society for the Promotion of Science(JSPS). This study was financially supported by the Austrian National Science Fund(FWF) under contract P26425 to GW.Regional ecosystem productivity is highly sensitive to inter-annual climate variability, both within and outside the primary carbon uptake period. However, Earth system models lack sufficient spatial scales and ecosystem processes to resolve how these processes may change in a warming climate. Here, we show, how for the European Alps, mid-latitude Atlantic ocean winter circulation anomalies drive high-altitude summer forest and grassland productivity, through feedbacks among orographic wind circulation patterns, snowfall, winter and spring temperatures, and vegetation activity. Therefore, to understand future global climate change influence to regional ecosystem productivity, Earth systems models need to focus on improvements towards topographic downscaling of changes in regional atmospheric circulation patterns and to lagged responses in vegetation dynamics to non-growing season climate anomalies

"Fresnel light drag in a coherently driven moving medium"

We theoretically study how the phase of a light plane wave propagating in a resonant medium under electromagnetically induced transparency (EIT) is affected by the uniform motion of the medium. For cuprous oxide (Cu2O), where EIT can be implemented through a typical pump-probe configuration, the resonant probe beam experiences a phase shift (Fresnel-Fizeau effect) that may vary over a wide range of values, positive or negative, and even vanishing, due to the combined effects of the strong frequency dispersion and anisotropy both induced by the pump. The use of such a coherently driven dragging medium may improve by at least 1 order of magnitude the sensitivity at low velocity in optical drag experiments

Optics of Nonuniformly Moving Media

A moving dielectric appears to light as an effective gravitational field. At low flow velocities the dielectric acts on light in the same way as a magnetic field acts on a charged matter wave. We develop in detail the geometrical optics of moving dispersionless media. We derive a Hamiltonian and a Lagrangian to describe ray propagation. We elucidate how the gravitational and the magnetic model of light propagation are related to each other. Finally, we study light propagation around a vortex flow. The vortex shows an optical Aharonov--Bohm effect at large distances from the core, and, at shorter ranges, the vortex may resemble an optical black hole.Comment: Physical Review A (submitted