Wide-Field Landers Temporary Keratoprosthesis in Severe Ocular Trauma: Functional and Anatomical Results after One Year

Purpose. To evaluate longitudinal functional and anatomical results after combined pars plana vitrectomy (PPV) and penetrating keratoplasty (PKP) using a wide-field Landers intraoperative temporary keratoprosthesis (TKP) in patients with vitreoretinal pathology and corneal opacity due to severe ocular trauma. Material and Methods. Medical records of 12 patients who had undergone PPV/PKP/KP due to severe eye trauma were analyzed. Functional (best-corrected visual acuity) and anatomic outcomes (clarity of the corneal graft, retinal attachment, and intraocular pressure) were assessed during the follow-up (mean 16 months). Results. Final visual acuities varied from NLP to CF to 2 m. Visual acuity improved in 7 cases, was unchanged in 4 eyes, and worsened in 1 eye. The corneal graft was transparent during the follow-up in 3 cases and graft failure was observed in 9 eyes. Silicone oil was used as a tamponade in all cases and retina was reattached in 92% of cases. Conclusions. Combined PPV and PKP with the use of wide-field Landers TKP allowed for surgical intervention in patients with vitreoretinal pathology coexisting with corneal wound. Although retina was attached in most of the cases, corneal graft survived only in one-fourth of patients and final visual acuities were poor

Relationship between the area of isopters and Vigabatrin dosage during two years of observation

Background The aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up. Methods 29 epilepsy patients were included into the study, but 15 individuals were excluded due to cognitive impairment, intracranial pathologies or eye diseases. Finally, 14 patients were examined with SKP before VGB treatment and after 6, 12, 18, and 24 months. Reaction time (RT)-corrected areas of three isopters (III4e, I4e and I2e) were measured for each of five examinations and compared intra-individually during 2-years period. Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as a control. Results There was a significant decrease of I2e, I4e and III4e isopters’ area during the follow-up of two years. Correlation was found between the I2e isopter’s area and both cumulative dose and mean daily dose of VGB. With increasing RT, there was decreasing of all isopters’ area in patients receiving VGB. In epilepsy patients who were not receiving VGB, there were no significance differences in isopters’ area during follow-up. Conclusion There was attenuation of area of III4e, I4e and I2e isopters obtained with SKP during a period of 2 years. RT, the cumulative dose and the mean daily dose of VGB influenced isopters' area obtained with SKP

Noninferiority of Preservative-free Versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients With Open-angle Glaucoma or Ocular Hypertension

Précis: Noninferiority of efficacy was demonstrated for a preservative-free latanoprost-timolol fixed combination compared with a BAK-containing formulation at 84 days after treatment in patients with open-angle glaucoma or ocular hypertension. Purpose: The purpose of this study was to compare the effect on intraocular pressure and safety of preservative-free latanoprost-timolol fixed combination (T2347) to benzalkonium chloride-preserved latanoprost-timolol fixed combination in patients with open-angle glaucoma or ocular hypertension. Methods: Phase III, randomized, parallel-group, investigator-masked study in 10 countries. A total of 242 patients aged 18 years or older with open-angle glaucoma or ocular hypertension in both eyes controlled with a preserved latanoprost-timolol fixed combination (15.7±2.4 mm Hg overall before inclusion) were randomized at day 0 with no washout period to receive the preservative-free alternative T2347 (N=127) or remain on the preserved comparator (N=115) for 84 days. Intraocular pressure changes from day 0 were measured at 9:00 am (±1 hour) on day 42 and day 84, and noninferiority of T2347 to the preserved comparator was analyzed statistically at day 84. Safety parameters were also reported. Results: The mean change in intraocular pressure from baseline to day 84 was -0.49±1.80 mm Hg for preservative-free T2347 and -0.49±2.25 mm Hg for the preserved comparator. These results met the noninferiority limits. Similar results were observed at day 42. There was no difference between groups in the incidence of adverse events or ocular signs. The total ocular symptoms score was better for T2347 than BPLT upon instillation at day 84 (45.9%/44.3%/9.8% of patients with improvement/no change/worsening vs. 33.6%/47.3%/19.1%; P=0.021), reflecting improvements in individual symptoms such as irritation/burning/stinging (P<0.001), and itching (P<0.01) on day 84. Conclusions: Preservative-free latanoprost-timolol fixed combination T2347 showed noninferior efficacy compared with the preserved comparator and was well tolerated

ANALYSIS OF THE INFLUENCE OF LANDFORMS ON LANDSCAPE MOLDING AND LAND MANAGEMENT

Landscaping has a major impact on the natural phenomena that occur on the surface of the Earth. Directive 2000/60/EC of the European Parliament and of the Council of Europe (23/10/2000) prescribes an obligation of sustainable management of water resources, including by protecting them against deterioration of water, aquatic and terrestrial ecosystems and wetlands dependent on water. Origins of wetlands and natural water reservoirs associated with the structure and the type of soil, topography, the surface flow of water in the hydrological cycle and the groundwater that emanates as a stream water under sloping impermeable layer. The Szwedow-Birghman equation describes the function of gravity relating flow of terrain which is density-plastic soil on slope surface. The movement of soil on sloping angle stops after reaching the final state. The final state will profile H = H0 that shows the terrain in stability condition. Over time, the shape of any profile will become regular independent of its original condition, and in its lower part forms a zone of accumulation, which under certain conditions, hydrological and soil will be a natural barrier for surface and underground water. The aim of this study was to develop methods to assess the stability of the terrain using modern methods of photogrammetry and geospatial and gain areas at risk of flooding acquisition and pollution associated with the flow of surface water and groundwater

ANALYSIS OF THE INFLUENCE OF LANDFORMS ON LANDSCAPE MOLDING AND LAND MANAGEMENT

Landscaping has a major impact on the natural phenomena that occur on the surface of the Earth. Directive 2000/60/EC of the European Parliament and of the Council of Europe (23/10/2000) prescribes an obligation of sustainable management of water resources, including by protecting them against deterioration of water, aquatic and terrestrial ecosystems and wetlands dependent on water. Origins of wetlands and natural water reservoirs associated with the structure and the type of soil, topography, the surface flow of water in the hydrological cycle and the groundwater that emanates as a stream water under sloping impermeable layer. The Szwedow-Birghman equation describes the function of gravity relating flow of terrain which is density-plastic soil on slope surface. The movement of soil on sloping angle stops after reaching the final state. The final state will profile H = H0 that shows the terrain in stability condition. Over time, the shape of any profile will become regular independent of its original condition, and in its lower part forms a zone of accumulation, which under certain conditions, hydrological and soil will be a natural barrier for surface and underground water. The aim of this study was to develop methods to assess the stability of the terrain using modern methods of photogrammetry and geospatial and gain areas at risk of flooding acquisition and pollution associated with the flow of surface water and groundwater

Additional file 1: of A simple and effective protocol for fast isolation of human Tenon’s fibroblasts from a single trabeculectomy biopsy – a comparison of cell behaviour in different culture media

Viability of the cells upon thawing. Report generated using a Countess automated cell counter upon thawing of HTFs isolated from sample 3. The vial contained 1.8 ml of cell suspension. (TIF 5742 kb

M1: Histoire de la Philosophie Médiévale. "Nécessité, contingence et hasard. Déterminisme et indéterminisme dans la tradition aristotélicienne médiévale arabe et latine" (P. Porro)

Histoire de la Philosophie Médiévale : PASQUALE PORRO M1 : Nécessité, contingence et hasard. Déterminisme et indéterminisme dans la tradition aristotélicienne médiévale arabe et latine Calendrier des séances: 27 novembre, 11 décembre, 13 décembre (rattrapage 15h00-18h00 salle F050) Second semestre, master 1 et master 2 en alternance, le mercredi 15h30-18h30 salle F 040 Les causes étant posées, est-il absolument nécessaire que leurs effets en découlent ? Pourquoi, dans le monde sublunaire, cer..