Crisis Management Patterns in the Lives of Ibna Al-Reza (PBUH); a Case Study of the Economic Crisis

A crisis is an unexpected and sometimes growing event that imposes problems on society and becomes an acute and unstable situation for individuals or society, the solution of which requires fundamental measures. In the history of Shiite Imamate, the years 203 to 260 AH (819 to 874 B. C.) are dedicated to the leadership and supervision of Ibna Al-Reza (PBUH), those Imamas who were the offsprings of Imam Reza (PBUH). Friendship with Imam Javad, Imam Hadi and Imam Askari (PBUH) was being led to consequences such as confiscation of property, dismissal from work, poverty and destitution. By taking measures and making decisions, Ibna al-Reza (PBUH) were able to improve the unfavorable economic situation of the Shiites. This article, which was organized by descriptive-analytical method, summarizes the actions of the late Shiite Imams in order to prevent and prepare confrontational and deterrent strategies in three stages: "before the crisis", "during the crisis" and "after the crisis". This article has categorized and introduced management principles that can be considered by citizens in the present era

Candiduria; a review article with specific data from Iran

Although, several categories of nosocomial infections are presented during the recent years, urinary tract infections (UTIs) considered as one of the most important systemic infections. The presence of Candida species in the urinary tract system (Candiduria) is seen in only 10-15% of the cases with UTI, however candiduria has been considered as more problematic infection for patients, laboratory workers and physicians. Due to increasing numbers of several predisposing factors, such as antibacterial agents, urinary tract instrumentation, diabetes mellitus, invasive therapies, and prolonged hospital stay, candiduria develops among the hospitalized patients, especially hospitalized in intensive care units (ICUs) and neonatal intensive care units (NICUs). According to the epidemiological studies, Candida albicans is the most common isolated species from candiduric patients. However, during the recent years, due to increasing resistance to antifungal drugs, non-albicans Candida species including, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis have been also implicated. We found that the mean prevalence of candiduria among Iranian patients was lower (16.5%) than worldwide ratio and also males were more frequently affected than females (M:F, 1.2:1). Similar to other countries, C. albicans was most common infectious agent followed by non-albicans Candida species including, C. glabrata, C. tropicalis and C. krusei

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene

Introduction: Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species. Methods: A total of 96 T. interdigitale and 45 T. mentagrophytes isolates were subjected to molecular typing by ribosomal ITS region. Antifungal susceptibility profiles for terbinafine, griseofulvin, clotrimazole, efinaconazole, luliconazole, amorolfine and ciclopirox were obtained by CLSI broth microdilution method. The squalene epoxidase (SQLE) gene was subjected to sequencing for mutations, if any, in isolates exhibiting elevated MICs for terbinafine. Results: Luliconazole and efinaconazole showed the lowest MIC values against T. mentagrophytes and T. interdigitale isolates. There were five isolates with terbinafine MICs >= 32 mu g/mL in our sample. They belonged to T. mentagrophytes type VIII and harbored two alternative SQLE gene sequence variants, leading to Phe397Leu and Ala448Thr or Leu393Ser and Ala448Thr substitutions in the enzyme. All terbinafine resistant strains could be inhibited by luliconazole and efinaconazole. Conclusion: This study documented a step in the global spread of resistance mechanisms in T. mentagrophytes. However, treatment alternatives for resistant isolates were available. Keywords:Trichophyton mentagrophytes; SQLE; terbinafine; antifungal drug resistance; Ira

Etiologic Agents of Otomycosis in the North-Western Area of Iran

Background: Otomycosis is a superfcial fungal infection often involves the pinna and external auditory canal. It is a pathologic condition, with Candida and Aspergillus, the most common fungal species. It is common worldwide but more prevalent in tropical and subtropical countries Objectives: The aim of this study was to determine the etiologic agents and local epidemiologic pattern of otomycosis in northwest Iran. Patients and Methods: A series of 140 patients with clinically symptomatic otomycosis were studied in 21 cities, towns, and villages throughout northwest Iran between 2009 and 2011. Clinical samples were collected by swabs and then assessed by mycological investigation. Results: Otomycosis was diagnosed in 129 cases (92%, 76 male, 53 female) with the highest prevalence of cases occurring in males between 21 - 40 years of age. From an etiological point of view, 116 patients (90%, 21 - 40 years old) were infected by saprophytic mold and 9 patients (7%) were infected by yeast. Three cases (2%) involved dermatophytes, and in one case (1%) the subject was infected with Eurotium (the perfect stage of Aspergillus fumigatus). Aspergillus niger was the most common mold that was isolated, followed by A. flavus, A. fumigatus, Penicillium spp., Fusarium spp., and Rhizopus spp. A total of 2 yeasts belonging to genus Candida, C. albicans and C. tropicalis, were isolated. Conclusions:Our study showed a high prevalence of otomycosis in the northwestern area of Iran. As such, proper diagnosis and treatment by aseptic techniques for this disease is urgently needed

A novel multilevel network slacks-based measure with an application in electric utility companies

In this paper, we developed an alternative Network Slacks-Based Data Envelopment Analysis Measure (NSBM) wherein the overall efficiency is expressed as a weighted average of the efficiencies of the individual processes. The advantage of this new model is that both overall efficiency and multi-divisional efficiencies have been calculated with a unified framework. The major merits of the proposed model are its ability to provide appropriate measure of efficiency, obtaining weight of processes from model, simultaneous assessment of intermediate variables considering them as both input and output. Finally, an application in electric power companies shows the practicality of the proposed model

Balanced Performance Assessment under uncertainty: An Integrated CSW-DEA and Balanced Scorecard (BSC)

Data Envelopment Analysis (DEA) is a mathematical programming model that calculates the relative efficiency of homogenous Decision Making Units (DMUs). The conventional DEA models used to calculate the efficiency require the exact amount of inputs and outputs; in real business situations, however, it is often impossible to determine the exact numeral value of some inputs and outputs. At the same time the Common Set of Weights (CSW) overcomes the weakness of DEA models for assessment under same conditions. On the other hands, it is important to considering the balance in evaluation and calculation of indicators. This study develops a new model to calculate the CSW in fuzzy environments, considering the balanced environment using the Balanced Scorecard (BSC). Our proposed model is linear for fairly and equitably evaluating the DMUs on the same scale, also enables us to deal with fuzzy environment and greatly reduces the computational complexities for enormous volumes of data in many real applications and treat difficulties in fuzzy DEA models. From a managerial point of view, this paper aims to provide an integrated framework to form a better strategic decision-making process about organization performance, which ultimately leads to the competitive advantages and success of the organization in the long run. Finally, in the field of performance management, the proposed model was applied to evaluate the performances of ten manufacturing enterprises in to confirm the validity and applicability of the proposed approach

In Vitro Anti-Candida Activity of Zataria multiflora Boiss

Zataria multiflora Boiss known as Avishan Shirazi (in Iran) is one of the valuable Iranian medicinal plants. The aim of study was to evaluate anti-Candida activity of Z. multiflora against different species of Candida in vitro. Anti-Candida activity of the aqueous, ethanolic and methanolic maceration extract of the aerial parts of Z. multiflora Boiss was studied in vitro. Anti-Candida activity against Candida species was done using serial dilutions of extracts in Sabouraud's dextrose agar. Minimal inhibitory concentration (MIC) of the methanolic and ethanolic extracts was 70.7 and 127 mg l−1, respectively. Aqueous extract showed no remarkable activity against Candida species. We conclude that methanolic extract of the aerial parts of Z. multiflora Boiss has more anti-Candida effect at 70.7 mg l−1 compared to ethanolic extract 127 mg l−1. In addition, the isolates of Candida parapsilosis were more susceptible to methanolic extract than other tested species

The efficacy of gaseous ozone against different forms of Candida albicans

Background and Purpose: Ozone is an inorganic molecule with effective antimicrobial properties. Clinical treatment of ozonated water was used for the elimination of Candida albicans, Enterococcus faecalis, endotoxins, and biofilms from root canals. In addition, its therapeutic effects for tinea pedis, ulcers, and leishmaniasis were investigated. The purpose of the present study was to evaluate the fungicidal effects of ozone on different forms of C. albicans. In addition, antifungal susceptibility profile of strains was assessed before and after exposure to ozone. Materials and Methods: Fifty strains of C. albicans were exposed to gaseous ozone at different times. Furthermore, biofilm formation and germ tube production were evaluated when yeast suspensions were exposed to ozone. In addition, antifungal susceptibility of ozone resistant colonies was investiagted as compared to controls. Results: Ozone was highly effective in killing C. albicans in yeast form and inhibition of germ tube formation during 210 and 180 s, respectively. Although with increasing exposure time biofilm production was considerably decreased, resistance to ozone was much higher among vaginal and nail isolates even after 60 min. All the strains were sensitive to fluconazole, caspofungin, and terbinafine pre- and post-ozone exposure. Resistance to amphotericin B was significantly enhanced after exposure to ozone. Conclusion: Although ozone was highly effective on the yeast form of C. albicans and it can inhibit the formation of germ tubes in C. albicans, the complete removal of biofilms did not happen even after 60 min. It seems that ozone therapy induces resistance to amphotericin B. &nbsp

Molecular identification, biofilm formation and antifungal susceptibility of Rhodotorula spp.

Luliconazole is an imidazole antifungal agent used in topical form for the treatment of onychomycosis and dermatophytosis. In vitro activity of luliconazole against dermatophytes, Candida, black fungi, Fusarium and Aspergillus species have been investigated. Rhodotorula spp. are environmental yeasts and emerged as opportunistic pathogens among immunocompromised patients. Rhodotorula’s human infections are usually resistant to treatment with antifungal drugs especially triazoles and echinocandins. The present study aimed at the molecular detection of environmental isolates of Rhodotorula spp. Then, antifungal efficacy of luliconazole was evaluated against isolates and compared to other routine systemic antifungals including; caspofungin, posaconazole, fluconazole, itraconazole, amphotericin B, and voriconazole. The biofilm production of Rhodotorula isolates was also evaluated. In this study, 39 isolates of Rhodotorula spp. were isolated from the environment, detected using molecular methods, and tested against luliconazole. Then, the anti-fungal activity of luliconazole compared with several routine antifungals. Also, biofilm formation by using a crystal violet staining assay was performed. Our finding showed that luliconazole has a very high minimum inhibitory concentration (MIC) value (1–8 µg/ml) against Rhodotorula spp. Besides, 100% of Rhodotorula strains were resistant to caspofungin, followed by fluconazole 94.7% and voriconazole 74.4%. Amphotericin B was demonstrated excellent in vitro activity against this genus. Our result indicated that 59% of Rhodotorula spp. were in the mid-range of biofilm production. Our results indicated that luliconazole does not effective against the genus Rhodotorula. Furthermore, amphotericin B is the best drug against this genus in comparison to caspofungin and other azole drugs

Lack of Cryptococcus gattii from Eucalyptus in Ahvaz

The basidiomycetous yeast genus Cryptococcus contains two medically important pathogens, Cryptococcus neoformans and C. gattii [1-3]. C. neoformans is one of the common pathogens in acquired immunodeficiency syndrome (AIDS), whereas the most cases of diseases due to C. gattii happened in the healthy individuals [2, 4]. C. gattii has a tendency to affect the respiratory and nervous systems of the humans and domestic animals such as, dogs, cats, and horses [5]. C. gattii is more geographically restricted than C. neoformans and is largely confined to tropical and subtropical regions. Several reports show that C. gattii was isolated from Eucalyptus trees (Eucalyptus tereticornis, E. citriodora and E. camaldulensis) in Australia [4, 6, 7]