The Association between Occupational Exposure to Pesticides and Cardiovascular Disease Incidence: The Kuakini Honolulu Heart Program.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

Objectification theory predicts college women’s attitudes toward cosmetic surgery

This study investigated cosmetic surgery attitudes within the framework of objectification theory. One hundred predominantlyWhite, British undergraduate women completed self-report measures of impression management, global selfesteem, interpersonal sexual objectification, self-surveillance, body shame, and three components of cosmetic surgery attitudes. As expected, each of the objectification theory variables predicted greater consideration of having cosmetic surgery in the future. Also, as expected, sexual objectification and body shame uniquely predicted socialmotives for cosmetic surgery, whereas self-surveillance uniquely predicted intrapersonal motives for cosmetic surgery. These findings suggest that women’s acceptance of cosmetic surgery as a way to manipulate physical appearance can be partially explained by the degree to which they view themselves through the lenses of sexual and self-objectification

The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import.

The phosphate carrier (PiC) of mammalian mitochondria is synthesized with a cleavable presequence, in contrast to other members of the mitochondrial family of inner membrane carrier proteins. The precursor of PiC is efficiently imported, proteolytically processed, and correctly assembled in isolated mitochondria. Here we report that a presequence-deficient PiC was imported with an efficiency of about 50% as compared with the authentic precursor of PiC. This mature-sized PiC was correctly assembled, demonstrating that the presequence is not essential for the assembly pathway. We found the following functions for the PiC presequence. (i) The presequence by itself was able to target a passenger protein to mitochondria with a low efficiency, suggesting that the mammalian PiC contains multiple targeting signals, the more efficient one(s) present in the mature protein part. (ii) Deletion of the presequence allowed a more efficient heterologous import of mammalian PiC into mitochondria from Saccharomyces cerevisiae and Neurospora crassa, indicating an important role of the presequence in determining the specificity of PiC import. (iii) Import of the presequence-deficient PiC required a higher membrane potential across the inner membrane than that of the presequence-carrying form. Therefore, the presequence also enhances the translocation of PiC into the inner membrane

Social Media in Relation to Cooperate Social Responsibility in Fast Food Industry

This paper focuses on analyzing the role of social media (Facebook, Twitter, Google+,Youtube) with regards to corporate social responsibility (CSR), specifically in the fast food industry. The objectives are to identify the use of social media platforms by fast food restaurants, identify if social media integrate corporate social responsibility in their business thereby limiting marketing of unhealthy meals on their websites, and lastly, to find out if marketing of fast food products on social platforms affect users, especially the young people between the age of 15 to 25. The study analyzed and monitored 70 fast food restaurants and their social media activities. 63 0ut of 70 were found to have at least three social media platforms where they promote their products to end users and none of the restaurants have any restriction in marketing any kind of product using social media. Results from questionnaire survey also found that many social media users get adverts from fast food restaurants with 13.85% being affected to buy the food most times and 47.69% sometimes. 81.54% of the participants also agreed that social media can do a great job in limiting the free marketing of unhealthy products by fast food restaurants. Keywords: Social Media, Corporate Social Responsibility (CSR), Stakeholders, fast food

Sickness presenteeism: measurement and management challenges

Since work can be restorative to health, attending work when unwell should not be viewed as an inherently negative phenomenon. However, the functional benefits are likely to depend on the health condition, and the psychosocial quality of the work provided. The current study used a workforce survey to explore differences in the pattern of presenteeism and absenteeism by health condition, the association of psychosocial work factors with presenteeism compared to absenteeism, and their interaction to predict health. Findings indicate that instead of substituting absenteeism for presenteeism, the two tend to coincide, but the balance differs by health condition. Presenteeism is more likely to occur in poorer psychosocial environments, reinforcing the importance of ensuring work is designed and managed in ways that are beneficial rather than detrimental to health. The findings also highlight the methodological importance of differentiating between the act and impact of presenteeism in future research and practice

Efficacy of HIV Postexposure Prophylaxis: Systematic Review and Meta-analysis of Nonhuman Primate Studies

Background. The efficacy of antiretrovirals as postexposure prophylaxis (PEP) to prevent viral acquisition was demonstrated in nonhuman primate models of human immunodeficiency virus (HIV) in the early 1990s. To complement the evidence base for efficacy of HIV PEP in humans, we systematically reviewed the published data on PEP efficacy across animal studies. Methods. PubMed, Web of Science, and Embase were searched from inception to 31 May 2014 for randomized and nonrandomized studies reporting seroconversions among uninfected animals exposed to HIV or simian immunodeficiency virus, irrespective of route of exposure. Seroconversion risk data were pooled using random-effects models, and associations explored through meta-regression. Results. Twenty-five studies (408 primates) were included for review. The risk of serconversion was 89% lower among animals exposed to PEP compared with those that did not receive PEP (odds ratio, 0.11 [95% confidence interval, .05-.23]). Heterogeneity was low (I2 = 0.0%). In meta-regression, a significant association was found between timing of PEP and seroconversion and the use of tenofovir compared with other drugs. Conclusions. This review provides further evidence of the protective benefit of PEP in preventing HIV acquisition, and the importance of initiating PEP as early as possible following virus exposur

Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control

FIP200 (focal adhesion kinase [FAK] family interacting protein of 200 kD) is a newly identified protein that binds to the kinase domain of FAK and inhibits its kinase activity and associated cellular functions. Here, we identify an interaction between FIP200 and the TSC1–TSC2 complex through FIP200 binding to TSC1. We found that association of FIP200 with the TSC1–TSC2 complex correlated with its ability to increase cell size and up-regulate S6 kinase phosphorylation but was not involved in the regulation of cell cycle progression. Conversely, knockdown of endogenous FIP200 by RNA interference reduced S6 kinase phosphorylation and cell size, which required TSC1 but was independent of FAK. Furthermore, overexpression of FIP200 reduced TSC1–TSC2 complex formation, although knockdown of endogenous FIP200 by RNA interference did not affect TSC1–TSC2 complex formation. Lastly, we showed that FIP200 is important in nutrient stimulation-induced, but not energy- or serum-induced, S6 kinase activation. Together, these results suggest a cellular function of FIP200 in the regulation of cell size by interaction with the TSC1–TSC2 complex

Mortality and Readmission After Cervical Fracture from a Fall in Older Adults: Comparison with Hip Fracture Using National Medicare Data

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115960/1/jgs13670.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/115960/2/jgs13670_am.pd

PP262—Can authorities take full advantage of the availability of generic atypical antipsychotic drugs? implications for the future

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Forecasting home sales in the four census regions and the aggregate US economy using singular spectrum analysis

Accurate forecasts of home sales can provide valuable information for not only, policy makers, but also financial institutions and real estate professionals. Given this, our analysis compares the ability of two different versions of Singular Spectrum Analysis (SSA) meth- ods, namely Recurrent SSA (RSSA) and Vector SSA (VSSA), in univariate and multivariate frameworks, in forecasting seasonally unadjusted home sales for the aggregate US economy and its four census regions (Northeast, Midwest, South and West). We compare the perfor- mance of the SSA-based models with classical and Bayesian variants of the autoregressive and vector autoregressive models. Using an out-of-sample period of 1979:8-2014:6, given an in-sample period of 1973:1-1979:7, we find that the univariate VSSA is the best performing model for the aggregate US home sales, while the multivariate versions of the RSSA is the outright favorite in forecasting home sales for all the four census regions. Our results high- light the superiority of the nonparametric approach of the SSA, which in turn, allows us to handle any statistical process: linear or nonlinear, stationary or non-stationary, Gaussian or non-Gaussian.http://link.springer.com/journal/106142017-12-31hb2016Economic