Cost-effective reduction of eutrophication in the Gulf of Kalloni (Island of Lesvos, Greece)

This study presents a cost-effective analysis by comparing the costs of measures (options) to improve the quality of bathing waters in the Gulf of Kalloni (island of Lesvos, Greece) in order to reduce the anthropogenic eutrophication in the coastal water of the Kalloni Gulf.The Gulf of Kalloni is a semi-enclosed gulf (115 km2) which receives municipal wastewater, agricultural activity drainage, and at times sewage from olive oil plants processing the local olives harvest. The area of study consists of the coastal waters and the river basin of which water run-off drains into the gulf. Four options are comparable in their environmental effectiveness to reduce eurtophication damages which are: municipal wastewater treatment plant, construction of dams, organic farming plus training and olive oil wastewater treatment plant

Seeking the factors to stimulate the users in coastal zones planning. Case study: Open discussions with mussel farmers in the Axios river (GR)

In the framework of an integrated coastal zone management, the involvement of users is required and “open discussions” is one of the techniques used for their participation. The authors used this technique during a project for the sustainable development of mussel-culture in the coastal zone of the Axios Delta. Open discussion contributed to the acceptance of the scientific results by the users of the aquatic environment (mussel-farmers) who addressed trade-offs in their own way. The majority of their arguments were incorporated in the formation of the management rules, presented in the final report of this project. The present paper summarizes this experience as well as the existing ways for the involvement of users in a decision planning process and demonstrates how open discussion is a prerequisite factor for the success of sustainable development planning in Greece

The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection.

Regular exercise is associated with pronounced health benefits. The molecular processes involved in physiological adaptations to exercise are best understood in skeletal muscle. Enhanced mitochondrial functions in muscle are central to exercise-induced adaptations. However, regular exercise also benefits the brain and is a major protective factor against neurodegenerative diseases, such as the most common age-related form of dementia, Alzheimer's disease, or the most common neurodegenerative motor disorder, Parkinson's disease. While there is evidence that exercise induces signalling from skeletal muscle to the brain, the mechanistic understanding of the crosstalk along the muscle-brain axis is incompletely understood. Mitochondria in both organs, however, seem to be central players. Here, we provide an overview on the central role of mitochondria in exercise-induced communication routes from muscle to the brain. These routes include circulating factors, such as myokines, the release of which often depends on mitochondria, and possibly direct mitochondrial transfer. On this basis, we examine the reported effects of different modes of exercise on mitochondrial features and highlight their expected benefits with regard to neurodegeneration prevention or mitigation. In addition, knowledge gaps in our current understanding related to the muscle-brain axis in neurodegenerative diseases are outlined

Mortality impact of AIDS in Abidjan, 1986-1992

To quantify the mortality impact of AIDS in the city of Abidjan (Côte d'Ivoire) by a full scale analysis of mortality trends before and after the onset of the epidemic. Data on deaths registered in the 10 vital registration centers of the city between 1973 and 1992, and data on causes of deaths in the four public hospitals were coded and investigated. Data on deaths were compared with census data in order to compute death rates. Life tables were computed for each of the 20 years of the study. The trends in death rates were analysed during the 10 years before the onset of the AIDS epidemic (1973-1982) and compared with the changing death rates in the following 10 years (1983-1992). Deaths attributable to AIDS were defined as those in excess of the original trends. The evolution in the number of deaths in the hospital allowed an analysis by cause of death. There was a marked increase in death rates starting in 1986, date of the first diagnosed AIDS cases in the city. This increase was significant for both sexes, but more pronounced among men. It was concentrated primarily among young adults (aged 25-44 years) and among older children (aged 5-14 years), and most of it was considered to be attributable to AIDS and related infections, tuberculosis in particular. When data were cumulated from 1986 to 1992, approximately 25000 persons were estimated to have died of AIDS. The high number of AIDS deaths estimated in Abidjan underlines the heavy toll already paid by african populations, and calls for intensive action. (Résumé d'auteur

Conséquences démographiques du sida en Abidjan : 1986-1992

Les statistiques de l'état civil et des formations sanitaires sont notoirement peu utilisées en Afrique pour étudier les tendances de la mortalité. L'étude d'Abidjan montre que c'est une situation très regrettable, car ces statistiques peuvent fournir de précieux renseignements sur l'état sanitaire de la population. Dans le cas présent, l'analyse fine des tendances de la mortalité, couplée avec l'analyse des causes de décès dans les hôpitaux, révèle assez précisément les conséquences démographiques du sida dans la capitale de la Côte d'Ivoire, malgré l'imperfection des données. Les estimations indiquent que près de 25 000 personnes seraient décédées du sida entre 1986 et 1992, les sept premières années de l'épidémie, ce qui confirme qu'Abidjan est une des villes les plus touchées au monde par cette troublante épidémie. Ce sont surtout les jeunes de sexe masculin qui ont été les plus touchés, dans toutes les couches de la société. Un modèle a permis de reconstruire la dynamique de l'épidémie, qui montre que le premier pic des infections se serait produit vers 1987. On peut s'attendre à une moyenne d'environ 7 000 cas de sida par an dans la ville jusqu'à l'an 2000, ce qui aura des conséquences importantes sur l'utilisation des infrastructures hospitalières. L'importance numérique de ces estimations souligne l'urgence de renforcer la lutte contre l'épidémie de sida en Côte d'Ivoire et dans le monde. (Résumé d'auteur

Importance Du Couplage De L’inventaire Des Plantes Mellifères Et De L’analyse Pollinique Des Miels De La Saison Des Pluies En Zone Ouest Soudanienne Au Nord-Bénin

The melliferous plants vary from one area to another according to biotic, climatic and ecological factors. This study was realized in the Sudanese region of Benin, in order to inventorize honey plants visited by the honeybee Apis mellifera adansonii Latreille. Pollen analysis of 34 samples of honey from three apiaries in the northwest of the country, combined with direct observations around each apiary within 1000 m radius were realized per month. In total 129 species were censised including 109 species inventorized on the field and 73 taxa identified through pollen analysis. Among these taxa, 43 are identified until species level. The contribution of pollen analysis to the knowledge of melliferous plants is 15.50%. The pollen analysis of honeys and visual inventory of honey plants field are two complementary methods of studying the honey flora

Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.

Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can result in ultrastructural muscle disruption, impaired excitation-contraction coupling, inflammation and muscle protein degradation. This process is associated with delayed onset muscle soreness and is referred to as exercise-induced muscle damage. Although a certain amount of muscle damage may be necessary for adaptation to occur, excessive damage or inadequate recovery from exercise-induced muscle damage can increase injury risk, particularly in older individuals, who experience more damage and require longer to recover from muscle damaging exercise than younger adults. Furthermore, it is apparent that inter-individual variation exists in the response to exercise-induced muscle damage, and there is evidence that genetic variability may play a key role. Although this area of research is in its infancy, certain gene variations, or polymorphisms have been associated with exercise-induced muscle damage (i.e. individuals with certain genotypes experience greater muscle damage, and require longer recovery, following strenuous exercise). These polymorphisms include ACTN3 (R577X, rs1815739), TNF (-308 G>A, rs1800629), IL6 (-174 G>C, rs1800795), and IGF2 (ApaI, 17200 G>A, rs680). Knowing how someone is likely to respond to a particular type of exercise could help coaches/practitioners individualise the exercise training of their athletes/patients, thus maximising recovery and adaptation, while reducing overload-associated injury risk. The purpose of this review is to provide a critical analysis of the literature concerning gene polymorphisms associated with exercise-induced muscle damage, both in young and older individuals, and to highlight the potential mechanisms underpinning these associations, thus providing a better understanding of exercise-induced muscle damage

Mitochondrial respiratory states and rate

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery