Transmission and reflection of Gaussian beams by anisotropic parallel plates

Explicit and compact expressions describing the reflection and the transmission of a Gaussian beam by anisotropic parallel plates are given. Multiple reflections inside the plate are taken into account as well as arbitrary optical axis orientation and angle of incidence.Comment: 20 page

Measurements of freestream density fluctuations in a hypersonic wind tunnel

Density disturbances in the freestream of the University of Southern Queensland’s Mach 6 wind tunnel (ρ∞≈34gm−3) have been measured using a focused laser differential interferometer (FLDI). The direct contribution of the turbulent shear layer from the Mach 6 nozzle to the FLDI signal was largely eliminated by mechanically shielding the FLDI beams from these effects. This improvement significantly enhanced the low wavenumber FLDI spectra which allowed a von Kármán spectrum fit and demonstrated a −5/3 roll-off in the inertial subrange and enabled the identification of the integral length scale (28–29 mm). The normalised root-mean-square density fluctuations were found to change over the flow duration (typically between 0.4 and 0.6%) for the 1–250 kHz frequency range which corresponds to the wavenumber range of 6– 1600 m−1 in this Mach 6 flow. Previous disturbance measurements using intrusive methods have identified a narrowband 3–4 kHz disturbance that is first measured in the core flow about 65 ms after the flow begins and remains until the flow terminates. The onset of this narrowband disturbance was previously correlated with transition-to-turbulence in the subsonic test gas supply to the nozzle. This correlation was investigated further herein, and the 3–4 kHz feature was inferred to be entropy mode disturbances by showing the departure of the FLDI measurements from Pitot pressure measurements. Through the comparison of FLDI and Pitot pressure data, Pitot pressure probes were demonstrated to produce a poor estimate of the static pressure fluctuations when non-isentropic disturbances are non-negligible

Laser-Induced Diaphragm Rupture for Improved Sequencing and Repeatability in a Hypersonic Facility

For hypersonic facilities where the flow conditions are established through the rupture of a diaphragm, such as in the University of Southern Queensland’s hypersonic wind-tunnel facility, the variability in the flow conditions is related to the uncertainty of the pressure at which the diaphragm ruptures. Variability in the diaphragm rupture pressure also results in uncertainty of the time at which the diaphragm will rupture. For experiments that require knowledge of when the test flow will be initiated, the sequencing of events relative to the flow onset is difficult when the flow is initiated using the natural rupture of a diaphragm. The challenge of experiment sequencing that arises due to rupture pressure variability is addressed by introducing a laser for rapid thermal weakening of the diaphragm. Event sequencing challenges are discussed in the context of free-flight testing, including model release strategies for such testing. The work proceeds through a review of Ludwieg tube flow initiation strategies and a discussion of the present context, which requires a reliable method for sequencing the retraction of the free-flight model holder. The natural variability of strength of the Mylar diaphragms in the present work is found to result in around ±6% uncertainty in rupture pressure. This rupture pressure variability is demonstrated to have a significant temperature dependence through empirical results and engineering models. Implementation of the laser-induced diaphragm rupture method is demonstrated to enhance repeatability in generating the flow conditions; the variability in rupture pressure was reduced to ±2% when the laser method was used. Based on the remaining sequencing uncertainties with the laser-induced rupture method and practical speeds for model platform retraction, uncertainty in the positioning of the free-flight models at the time of flow onset is shown to be ±2  mm

Time-resolved stagnation temperature measurements in hypersonic flows using surface junction thermocouples

Fast-response coaxial surface junction thermocouples have been used to measure time-resolved stagnation temperature of the Mach 6 flow produced by the University of Southern Queensland’s hypersonic wind tunnel, TUSQ. The piston compression and the nozzle expansion of the test gas were found to be approximately isentropic for the first 65 ms of flow. Thereafter, the stagnation temperature reduces from due to the heat lost to the cold barrel, and this process can be modelled based on the measured barrel pressure history to simulate the stagnation temperature in TUSQ to within 2% of the actual value for the first 150 ms of flow. By operating the thermocouples at the flow stagnation temperature, the fluctuations of the flow stagnation temperature were investigated. A 3–4 kHz narrowband stagnation temperature fluctuation appearing after was measured, and found to be correlated with the transition to turbulence of the flow in the barrel

Ground to Flight Investigations of Hayabusa with Ablation Effects

Thermal protection systems (TPS) are of extreme importance for the survival of space vehicles especially during superorbital re-entry to Earth. The design of thermal protection systems requires in-depth knowledge of the thermal loading experienced during a re-entry. The thermal loading data is mostly determined using ground testing and can be backed up by modelling activities including computational fluid dynamics (CFD). The verification of this data with flight data is invaluable and a recent, rare example of an opportunity for comparison was the Hayabusa asteroid sample return mission, which landed in Australia in 2010. During this re-entry a team of international scientists collected spectral data which can now be used for comparison and verification of ground test and modelling/CFD data. Ground testing of subscale models at flight equivalent hypervelocity flow conditions (8 − 12 km/s) can be performed in hypersonic impulse facilities such as the X2 expansion tunnel at The University of Queensland. A recently developed method at The University of Queensland enables heated reinforced carbon-carbon (RCC) models to be tested at temperatures repre- sentative of those experienced in flight ( 2000 − 3000 K), in addition to testing with cold-wall metallic models. Hot wall testing allows more realistic simulation of re-entry flow characteristics including important thermal surface effects (surface chemistry, catalycity) which has previously not been possible. The eilmer3 compressible flow CFD code is used extensively for simulating atmospheric re-entry vehicles at flight and laboratory conditions. Simulations of the Hayabusa aeroshell incorporate heated walls, as well as surface catalycity, to accurately model the conditions experienced by the TPS. These simulations can be coupled with SACRAM, a 1D ablation modelling code, to include the effects of ablation and recession at critical points on the model surface. Current work is investigating the effects and validity of heat flux scaling correlations applied to a range of scaled models with the Hayabusa geometry and flight equivalent flow conditions. This will be achieved through results of CFD simulations, incorporating radiation and ablation modelling, and expansion tunnel testing with hot and cold wall models. Increased understand- ing of scaling methods will allow higher fidelity heat loading data to be acquired allowing more efficient and effective design of TPS. This paper will discuss results from CFD simulations coupled with ablation modelling and modelled surface chemistry. An outline of planned experiments in the X2 expansion tunnel, including background on the RCC heating method and condition development, will also be presented

Radiation-Ablation Coupling for Capsule Reentry Heating via Simulation and Expansion Tube Investigations

A capsule entering a planetary atmosphere at hypersonic speeds experiences high levels of radiative heating. Furthermore, coupling between the ablation products from the surface of the vehicle and the high temperature gas can have a major effect on the head load experienced by the vehicle. This paper discusses a collaborative project aimed at better characterising the flow processes involved. A ground-based expansion tube facility is described in which radiation-ablation coupling is achieved through the use of a pre-heated model placed in a high temperature flow. In parallel, simulation techniques are being developed to model the complex chemical processes occurring in the flow

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection

Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC). IS was supported by The University of Queensland Centennial and IPRS Scholarships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.

Tyrosine kinase inhibitors represent today's treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective randomized CML-study IIIA recruited 669 patients with newly diagnosed CML between July 1997 and January 2004 from 143 centers. Of these, 427 patients were considered eligible for HSCT and were randomized by availability of a matched family donor between primary HSCT (group A; N=166 patients) and best available drug treatment (group B; N=261). Primary end point was long-term survival. Survival probabilities were not different between groups A and B (10-year survival: 0.76 (95% confidence interval (CI): 0.69-0.82) vs 0.69 (95% CI: 0.61-0.76)), but influenced by disease and transplant risk. Patients with a low transplant risk showed superior survival compared with patients with high- (P<0.001) and non-high-risk disease (P=0.047) in group B; after entering blast crisis, survival was not different with or without HSCT. Significantly more patients in group A were in molecular remission (56% vs 39%; P=0.005) and free of drug treatment (56% vs 6%; P<0.001). Differences in symptoms and Karnofsky score were not significant. In the era of tyrosine kinase inhibitors, HSCT remains a valid option when both disease and transplant risk are considered