Una nueva estampilla epigráfica sobre ánfora púnica hallada en la necrópolis de Cádiz

Durante las excavaciones llevadas a cabo en un solar de Cádiz correspondiente al área clásica de la necrópolis fenicio-púnica y romana, en una fosa rellena con material púnico de finales del s. III a.C., apareció sobre un fragmento de ánfora centromediterránea una estampilla epigráfica que amplía el número de documentos de este tipo hasta hoy conocidos. El epígrafe parece abreviar un nombre personal púnico, lo que confirmaría la interpretación antroponímica de la mayor parte de este tipo de inscripciones y sugiere de nuevo la ligazón, aún discutida, de los individuos citados con el ámbito de producción de las ánforas. Por otro lado, el contexto de aparición del ánfora estampillada vuelve sobre el problema de la interpretación de los restos amortizados en estas estructuras que, en última instancia, nos remiten a la celebración de banquetes en ambientes funerarios.A new fragment of a Centre-Mediterranean Amphora stamped with an epigraphical seal was found during recent excavations in an empty lot of the city of Cadiz. The area corresponds to a part of the main Phoenician-Punic and Roman necropolis of the old city. The fragment was found in an old, unused trench filled with Punic materials (from the end of the III century B. C. E.). The new finding extends the number of this kind of documents known until now. The text of the stamp-seal seems to correspond to the abbreviation of a Punic personal name. This fact supports the anthroponomical interpretation of most inscriptions of this type and suggests that they link the individuals mentioned in the seals with the processes of production of the amphorae, although this is still the subject of discussion. On the other hand, the context of finding of the new stamped amphora brings up, once again, the problem of the interpretation of this kind of remains (refilled pits and trenches in the necropolis), which could refer to the celebration of banquets in funeral areas

Punic amphora stamps and graffiti found in the area of “Los chinchorros” (San Bartolomé Street, Cádiz)

Durante los años 2007 y 2008 fueron llevadas a cabo excavaciones arqueológicas preventivas, bajo la dirección de M. L. Lavado, en la zona conocida popularmente como “Los Chinchorros”, a extramuros de la ciudad moderna de Cádiz. Los trabajos permitieron recuperar datos sobre la distribución al sur del recinto urbano de Gadir/Gades de la necrópolis fenicia arcaica, de los saladeros de pescado púnicos y de otras actividades artesanales y funerarias de época romana republicana e imperial. Los contextos excavados en relación a la actividad conservera de época púnica y tardopúnica aportaron una ingente cantidad de material mueble, entre el cual destaca el enorme número de ánforas y fragmentos de vajilla barnizada documentados en algunas fosas empleadas como vertedero. Entre estos materiales sobresale la presencia de varios sellos anfóricos, tanto locales como de origen púnico centromediterráneo, así como varios grafitos grabados sobre piezas de vajilla. El escaso número de marcas de estos tipos estudiadas en el ámbito de la bahía, así como el contenido epigráfico e iconográfico de los sellos y su relación con contextos artesanales han motivado su estudio específico, aportando nuevos indicadores sobre fenómenos de compleja lectura histórica como el relativo al sellado de las ánforas. Se presentan cinco marcas inéditas correspondientes a la actividad de talleres locales y tres más (epígrafes bilíteros en dos de los casos) asociadas a importaciones de envases de transporte cartagineses.The salvage excavations carried out during 2007 and 2008 conducted and directed by M. L. Lavado in the area popularly known as “Los Chinchorros”, outside the walls of the modern city of Cadiz, allowed the recovery of archaeological data from the south of the urban area of Gadir/Gades. This new data attested the presence there of the archaic Phoenician necropolis, Punic fish salting facilities and other artisanal and funerary areas dating to the Roman period. The contexts excavated in relation to the Punic and late Punic fish processing activities provided an outstanding amount of artifacts, including a large number of amphorae and fragments of glazed tableware documented in some dumping pits. Among these materials, the presence of several amphorae stamps, both local and of Carthaginian origin, stands out, as well as several graffiti engraved on tableware vessels. The limited number of marks of these types that have been studied in the area of Cadiz bay, as well as the epigraphic and iconographic content of the stamps and their relationship with artisanal contexts have motivated a specific analysis, providing new insights about phenomena of complex historical interpretation such as the stamping of amphoras. Eight unpublished marks are discussed, five corresponding to the activity of local pottery workshops, and three more (biliteral epigraphs in two of the cases) that can be linked to Carthaginian transport containers

Culto y culturas en la cueva de Gorham (Gibraltar): La historia del santuario y sus materiales inscritos

This paper presents an updated overview of the ongoing archaeological research carried out in the Protohistoric sanctuary of Gorham’s Cave (Gibraltar). It is based on the results of recent excavations, focusing on incised pottery with inscriptions or other marks. The catalogue of inscriptions includes both Phoenician and Graeco-Iberian examples, which could be related with the deposition of votive offerings from Archaic to Hellenistic periods.El artículo presenta un nuevo estado de la cuestión arqueológico sobre el santuario protohistórico de la Cueva de Gorham (Gibraltar) a la luz de los resultados de las recientes campañas de excavación y estudia los materiales cerámicos con inscripciones u otro tipo de marcas hallados en la cueva. El catálogo incluye un nuevo grafito fenicio y una inscripción greco-ibérica que se relacionan con las ofrendas depositadas en el lugar desde época arcaica hasta el periodo helenístico

Surgical treatment for liver haematoma following endoscopic retrograde cholangiopancreatography: An unusual case

AbstractBackgroundEven in expert hands, there can be serious complications when performing an endoscopic retrograde cholangiopancreatography. The most frequent complications are pancreatitis, cholangitis, bleeding, perforation, and acute cholecystitis. The hepatic subcapsular haematoma is a rare complication, with few cases described worldwide.ObjectiveA case is presented of an extremely rare complication of endoscopic retrograde cholangiopancreatography, which required surgical treatment for its resolution without success. This is second case of mortality reported in the literature.Clinical caseFemale patient of 30 years old, with indication for endoscopic retrograde cholangiopancreatography due to benign strictures. A hydro-pneumatic dilation and stent placement of 2 gauge 10Fr was performed. She presented abdominal pain after the procedure and significant decline in haemoglobin with no evidence of haemodynamic instability so an abdominal tomography scan was performed, showing no evidence of liver injury. The patient was haemodynamic unstable within 72h. A laparotomy was required for damage control, with fatal outcome in the intensive care unit due to multiple organ failure.ConclusionSubcapsular hepatic haematoma after endoscopic retrograde cholangiopancreatography is a rare complication, with few cases reported in the literature. Treatment described in the literature is conservative, resulting in a satisfactory resolution

An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

<p>Abstract</p> <p>Background</p> <p>Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant relapse.</p> <p>Methods</p> <p>We included 153 patients with stage I-II hormonal receptor-positive breast cancer. RNA was isolated from formalin-fixed paraffin-embedded samples and qRT-PCR amplification of 83 genes was performed with gene expression assays. The genes we analyzed were those included in the 70-Gene Signature, the Recurrence Score and the Two-Gene Index. The association among gene expression, clinical variables and distant metastasis-free survival was analyzed using Cox regression models.</p> <p>Results</p> <p>An 8-gene prognostic score was defined. Distant metastasis-free survival at 5 years was 97% for patients defined as low-risk by the prognostic score versus 60% for patients defined as high-risk. The 8-gene score remained a significant factor in multivariate analysis and its performance was similar to that of two validated gene profiles: the 70-Gene Signature and the Recurrence Score. The validity of the signature was verified in independent cohorts obtained from the GEO database.</p> <p>Conclusions</p> <p>This study identifies a simple gene expression score that complements histopathological prognostic factors in breast cancer, and can be determined in paraffin-embedded samples.</p

Electrochemical corrosion behavior of passivated precipitation hardening stainless steels for aerospace applications

Precipitation-hardening (PH) stainless steels (SS) are widely used in various aerospace applications. These steels exhibit good mechanical and corrosion resistance. The electrochemical behavior of 15-5PH, 17-4PH, Custom450 and AM 350 stainless steels passivated with citric and nitric acid baths for 60 and 90 min at 25 and 49 °C were evaluated in 5 wt.% sodium chloride (NaCl) and 1 wt.% sulfuric acid (H2SO4) solutions. The electrochemical behavior was studied with potentiodynamic polarization curves (PPC) according to the ASTM G5-13 standard. The results indicated that there are two characteristic mechanisms that are present in the potentiodynamic polarization curves. When the PHSS is immersed in an H2SO4 solution, there is a secondary passivation, and in the NaCl solution, there is a pseudo-passivation (not stable passivation film). The current densities in the NaCl solution were between 10−4 and 10−5 mA/cm2, while those of H2SO4 were recorded around 10−2 and 10−3 mA/cm2. Citric acid does work as a passivating solution, and in some cases, the corrosion resistance of the stainless steel was comparable to that of nitric acid

Corrosion Behaviour of 304 Austenitic, 15-5PH and 17-4PH Passive Stainless Steels in acid solutions

The objective of this work was to study is use electrochemical techniques to determinate the growth conditions, characteristics and resistance of passive layers of stainless steel (SS): 304 austenitic, 17-4PH (precipitation hardening) and 15-5PH. Passivation of the SS was performed in 15% citric acid at temperatures of 25 and 49 °C. The corrosion kinetics was obtained using the electrochemical technique as potentiodynamic polarization (PP), in a three-electrode system. The electrolytes used were sodium chloride (5 wt. % NaCl) and sulfuric acid (1 wt. % H2SO4). Passivation in citric acid allows obtain passive layers at temperatures of 49°C with immersion times of 30 minutes. In precipitation hardening steels, passive layers up to 360 mV in sodium chloride. Can be obtained. In sulfuric acid, there is a mechanism of passivation – transpassivation - secondary passivation, this due to the high electropositive values of potential

Manuales y textos de enseñanza en la universidad liberal : VII congreso internacional sobre la historia de las universidades hispánicas

Congreso Internacional de Historia de las Universidades Hispánicas (VII, 2004: Universidad Carlos III de Madrid)El libro edita las actas del VII Congreso internacional sobre la historia de las universidades hispánicas celebrado los días 16-18 de noviembre de 2000 en el campus de Colmenarejo de la Universidad Carlos III de Madrid. Fue una reunión científica monográfica sobre los manuales y textos de enseñanza en la universidad liberal. Contó con un conjunto de ponencias que se adentraron en los ámbitos de la economía, el derecho público, el derecho privado, la filosofía y la medicina. Otras muchas cuestiones fueron analizadas en las comunicaciones.Presentación / Manuel Ángel Bermejo Castrillo. -- Una ciencia peligrosa: la enseñanza de la economía en la Universidad española / Pedro Fraile Balbín. -- La enseñanza del derecho público en España. Un ensayo critico / Alfredo Gallego Anabitarte. -- La enseñanza del derecho privado en la Universidad liberal /Ángel M. López y López y Cecilia Gómez-Salvago Sánchez. -- La enseñanza de la filosofía en la Universidad decimonónica (Asignaturas y textos oficiales) / Antonio Jiménez García. -- Manuales y textos de enseñanza médica en la Universidad liberal: la España del siglo XIX / José M. López Piñero. -- ¿Política o Academia? La disputa en torno al texto de lógica en la escuela nacional preparatoria / María de Lourdes Alvarado. -- La enseñanza del derecho natural y de gentes: el libro de Heineccio / Antonio Álvarez de Morales. -- Manuales y libros de texto utilizados en las escuelas industriales españolas durante la época isabelina / José Manuel Cano Pavón. -- Las bibliotecas universitarias en España durante la revolución liberal / Genaro Luis García López. -- Il magistero di Corrado Segre a Torino. I quaderni manoscritti delle lezioni universitarie (1888-1924) / Livia Giacardi. -- Los manuales de literatura en la facultad de Filosofía (1846-1867) / Jean-Louis Guereña. -- Los asertos de conclusiones públicas de Filosofía en el Colegio del Rosario durante la época de la Universidad Central (1826-1842) / María Clara Guillén de Iriarte. -- Vattel larva detracta. Reflexiones sobre la recepción del Ius Publicum Europaeum en la Universidad preliberal española / Pablo Gutiérrez Vega. -- La enseñanza del derecho en la Argentina por dos pequeños grandes libros: el Álvarez y el prontuario de Castro / Alberto David Leiva. -- Los libros útiles o la utilidad de los libros. Manuales de derecho entre 1841 y 1845 / Manuel Martínez Neira. -- L’insegnamento della storia nell’università italiana dopo l’unità / Mauro Moretti e Ilaria Porciani. -- Manuales de historia de filosofía en España (s. XIX) / Laureano Robles. -- L’insegnamento della matematica all’università di Torino (1848-1948). Aspetti storici, istituzionali e scientifici / Clara Silvia Roero. -- La enseñanza del derecho natural en el último tercio del siglo XIX / Salvador Rus Rufino. -- Un español republicano en Argentina: Juan Bialet Massé. Sus textos de anatomía y manual de medicina legal / María Cristina Vera de Flachs. -- La docenza del giansenista Pietro Tamburini a Pavia nel periodo francese. Un esperimento di sintesi tra etica teologica e diritti dell’uomo all’ombra dell’albero della libertà /Emauela Verzella Pettiti. -- El sentido humanista de la Universidad. Comentario a un texto de 1930: Misión de la Universidad, de José Ortega y Gasset / Javier Zamora Bonill

Comunidad de Aprendizaje Práctico Universitario (CAPU) para la realización de Trabajos Fin de Grado en el Departamento de Derecho Internacional

Memoria del Proyecto de Innovación Docente UCM nº 144/2022, que tiene por objeto una metodología para la realización del Trabajo de Fin de Grado de las asignaturas de Derecho Internacional Privado y Derecho Internacional Público, mediante una serie de preguntas elaboradas por el grupo de profesores sobre un conflicto o controversia internacional, de tal forma que el tema y las preguntas a responder por los alumnos esté preestablecido.Depto. de Derecho Internacional, Eclesiástico y Filosofía del DerechoFac. de DerechoFALSEsubmitte

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E−4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E−4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease.Tis project was funded in part by CRIS CANCER FOUNDATION