Factors Associated with Influenza Vaccine Uptake among Pregnant Women: Analysis of the 2015 Georgia Vital Events Information System Birth Worksheet

ABSTRACT INTRODUCTION: Influenza is a public health concern each influenza season in the United States (US). Annually, about 50,000 people die due to influenza complications in the US. Pregnant women and children under the age of five are two of the most at-risk groups for influenza-related morbidity and mortality. Since 2004, the Centers for Disease Control (CDC), the Advisory Committee on Immunization Practice (ACIP), and the American College of Obstetricians and Gynecologists (ACOG) have recommended that women who will be pregnant during the influenza season get vaccinated. Vaccination of mothers also protects infants for up to the first six months of life through the active transfer of maternal antibodies in the womb. Vaccination during pregnancy is safe and is the most effective way for mothers to protect themselves and their infants from the influenza virus. PURPOSE: Vaccination rates among pregnant women in Georgia are low, despite the CDC, ACIP, and ACOG recommendation to be vaccinated for influenza during pregnancy. In 2013, only 23.7% of women in Georgia received an influenza vaccine before or during pregnancy, a number well below the national average of 55.3% for the same year. The purpose of this study is to determine which factors are positively associated with influenza vaccine uptake during 2 pregnancy in Georgia through an analysis of the 2015 Georgia Vital Events Information System (VEIS) Birth Worksheet. The author believes that by identifying which factors show an increase in vaccine uptake, clinicians will be able to beneficially direct vaccine promotion efforts among pregnant women in Georgia. METHODS: Secondary data from the 2015 VEIS Birth Worksheet was obtained from the Georgia Department of Public Health. 130,133 women between the ages of 18 – 49 completed a Birth Worksheet in 2015 and were included in the study. Variables used for regression analysis, descriptive analysis, and prevalence of vaccine uptake include: age, race, education level, perinatal region of residence, and receipt of prenatal care. An extensive review of existing literature was also conducted. RESULTS: The prevalence of influenza vaccine uptake among pregnant women varied across the variables. 13.39% of women who completed a Birth Worksheet in 2015 reported that they received an influenza vaccine during pregnancy. The prevalence of vaccine uptake was highest among white women (65.26%), women between the ages of 25 – 34 (60.16%), women with a college degree (51.03%), and women living in the Atlanta perinatal region (44.52%). Surprisingly, of all the Atlanta region respondents, only 10.32% received an influenza vaccine despite having the largest population of all the regions in Georgia. Almost all women who received an influenza vaccine during pregnancy also received prenatal care (98.48%). Of the 115,443 women who received prenatal care, 14.87% received an influenza vaccine

Faktor-Faktor yang Mempengaruhi Keputusan Penggunaan Ojek Online di Kota Tegal pada Masa Pandemi Covid 19

This study was aimed to test and analyze how much influence internal and external factors have on the decisions of online motorcycle taxi users in Tegal City. The sampling technique used in this study was a convenience sampling method. The sample used in this study were 118 respondents who had used online motorcycle taxi transportation. The data used in this study were primary data and secondary data with data collection techniques using observation, interviews, literature study, and questionnaires. Data analysis techniques used in this study were validity test; reliability test; classical assumption test namely normality test, multicollinearities, heteroscedasticity, and autocorrelation; multiple regression analysis, t-test (partial), f-test (simultaneous), and the coefficient of determination. The results of data analysis are known based on the results of hypothesis testing that the internal factor variable (x1) partially affects the decision of online motorcycle taxi users, the external factor variable (x2) partially affects the decision of online motorcycle taxi users and internal factor variables and external variables simultaneously influence the decisions of online motorcycle taxi users.Keywords: Internal Factors, External Factors, User Decisions ABSTRAKPenelitian ini bertujuan untuk menguji dan menganalisis seberapa besar pengaruh faktor internal dan faktor eksternal terhadap keputusan pengguna ojek online di Kota Tegal. Teknik pengambilan sampel menggunakan metode convenience sampling. Sampel yang digunakan dalam penelitian ini sebanyak 118 responden yang pernah menggunakan transportasi ojek online di Kota Tegal. Data yang digunakan dalam penelitian ini adalah data primer dan data sekunder dengan teknik pengumpulan data dengan metode observasi, wawancara, studi pustaka dan kuesioner. Teknik analisis data menggunakan (1) Uji validitas, (2) Uji reliabilitas, (3) Uji asumsi klasik, yaitu uji normalitas, multikolineartas, heteroskedastisitas, dan autokorelasi, (4) Analisis regresi berganda, uji t (parsial), uji f (simultan), dan koefisien determinasi. Hasil analisis data diketahui berdasarkan hasil uji hipotesis bahwa variabel faktor internal (x1) secara parsial berpengaruh terhadap keputusan pengguna ojek online, variabel faktor eksternal (x2) secara parsial berpengaruh terhadap keputusan pengguna ojek online serta variabel faktor internal dan variabel eksternal berpengaruh secara simultan terhadap keputusan pengguna ojek online.Kata Kunci: Faktor Internal, Faktor Eksternal, Keputusan Penggun

Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice

Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression

PENGARUH KEPEMIMPINAN, MOTIVASI, DAN DISIPLIN TERHADAP KINERJA KARYAWAN DI LINGKUNGAN TEAM LEADER PT. KARYA NIAGA ABADI (J&T) GRESIK

Penelitian ini bertujuan untuk melakukan pengujian pengaruh kepemimpinan, motivasi, dan disiplin terhadap kinerja karyawan di lingkungan team leader. Jumlah sampel dalam penelitian ini 48 orang pegawai Di PT. Karya Niaga Abadi (j&t) Gresik. Analisis data yang digunakan adalah analisis regresi linier berganda. Hasil penelitian ini menyimpulkan bahwa hasil pengujian secara simultan kepemimpinan, motivasi, dan disiplin berpengaruh signifikan terhadap kinerja karyawan di lingkungan team leader. Hasil pengujian secara parsial kepemimpinan berpengaruh positif dan signifikan terhadap kinerja karyawan. Hasil pengujian secara parsial motivasi juga berpengaruh positif dan signifikan terhadap kinerja, dan Disiplin juga berpengaruh positif dan signifikan terhadap kinerja

Evaluation of potential complication of interstitial lung disease with abemaciclib and palbociclib treatments

Background: Various cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have demonstrated promising anti-tumor effects. The Japanese Ministry of Health, Labour and Welfare has issued a warning about interstitial lung diseases as an adverse effect of CDK4/6 inhibitors. However, a large-scale evaluation of potential complications has not been conducted to date, and the occurrence of these adverse effects is unclear. Aim: The aim of this study was to evaluate the clinical incidence of interstitial lung disease caused by two CDK4/6 inhibitors, abemaciclib and palbociclib, and assess the relationship between each drug and interstitial lung disease. Methods and results: We evaluated the relationship between the CDK4/6 inhibitors (abemaciclib and palbociclib) and interstitial lung disease in clinical practice using data from the Japanese Adverse Drug Event Report (JADER) database and FDA Adverse Event Reporting System (FAERS) to detect adverse event signals with reported odds ratios (RORs). Furthermore, we performed an adverse event-time analysis for each drug using data from the JADER database to examine the time of onset of the adverse events. The analysis of the reports in the JADER database showed that the lower limit of the 95% confidence interval (CI) of ROR for abemaciclib was >1 regardless of age, and a signal was detected. Interstitial lung disease associated with abemaciclib and palbociclib use has been reported, with an average onset period from treatment initiation [median (25th-75th quartile)] of 65.1 [56.0 days (25.3-98.3 days)] and 53.1 days [38.0 days (10.8-76.0 days)], respectively. The analysis of the reports in the FAERS showed that the lower limit of the 95% CI of the ROR for the two drugs was >1, and a signal was detected. Conclusion: Treatment with abemaciclib and palbociclib is associated with a potential complication of interstitial lung disease, regardless of age

Prevalence and profile of depressive mixed state in patients with autism spectrum disorder

Purpose: The present study aimed to clarify prevalence and profile of depressive mixed state (DMX) in depressed individuals with autism spectrum disorder (ASD). Patients and methods: The Quick Inventory of Depressive Symptomatology Self-Report Japanese version (QIDS-SR-J) and global assessment of functioning (GAF) were administered to 182 consecutive patients (36 ASD and 146 non-ASD subjects) with a major depressive episode (MDE). DMX was categorically diagnosed according to the criteria for mixed depression (MD) by Benazzi and mixed features (MF) specifier by DSM-5. Severity of DMX was assessed by the self-administered 12-item questionnaire for DMX (DMX-12). Clinical backgrounds and incidence/severity of DMX were compared between the ASD and non-ASD groups. Results: ASD patients showed higher prevalence of MD than non-ASD patients (36.1% versus 18.5%). Mood lability, distractibility, impulsivity, aggression, irritability, dysphoria and risk-taking behavior as mixed symptoms were more prevalent in ASD patients than those in non-ASD patients, together with higher scores of total DMX-12 and its disruptive emotion/behavior cluster. Multiple regression analysis revealed significant contribution of ASD to the disruptive emotion/behavior symptoms. Conclusion: Careful monitoring and management of potential DMX are warranted in depressed ASD individuals

¿En qué medida se han implementado los principios del Comité de Basilea en el directorio de las Cajas Municipales de Ahorro y Crédito? Una propuesta de lineamientos para el fortalecimiento del gobierno corporativo

Las Cajas Municipales de Ahorro y Crédito (CMAC) presentan una serie de particularidades que las diferencian del resto de empresas que conforman el sistema financiero peruano como, por ejemplo, la composición de su directorio, el cual está conformado, según su Ley especial, por representantes de la Municipalidad (único accionistas en la mayoría de las CMAC) y de la sociedad civil, como el clero, la cámara de comercio, COFIDE y la asociación de pequeños comerciantes y productores. En tal sentido, debido a estas particularidades y naturaleza jurídica, la hipótesis es que la regulación peruana no incorpora de manera adecuada, para el caso de las CMAC, los Principios de gobierno corporativo emitidos por el Comité de Basilea. Así, el objetivo consiste en determinar si el marco regulatorio peruano aplicado a las CMAC incorpora adecuadamente dichos principios, en particular, en lo que respecta a la composición y modo de designación de los miembros de su directorio. Para realizar el análisis, se consideró la metodología establecida por el Fondo Monetario Internacional y el Banco Mundial en su Programa de evaluación del Sector Financiero (FSAP, por sus siglas en inglés), empleado para evaluar el grado de adherencia de un país con relación a los Principios de Supervisión Bancaria establecidos por el Comité de Basilea. Como resultado del análisis, se identificó que 71% de los criterios evaluados se consideraron “cumplido”; es decir, que son recogidos por la regulación peruana de forma íntegra, mientras que un 19% fueron considerados como “parcialmente cumplidos” y 2% como “no cumplidos”. En consecuencia, sobre la base de dichos resultados, se establece un conjunto de lineamientos generales para que la Superintendencia de Banca, Seguros y AFP (SBS) pueda incorporarlos en la normativa aplicable o utilizarlos como directrices en la interpretación del marco legal y regulatorio vigente a las CMAC, con la finalidad de que contribuyan a fortalecer el gobierno corporativo de las CMAC.Tesi

Sequencing Mixed Model Assembly Line Problem to Minimize Line Stoppages Cost by a Modified Simulated Annealing Algorithm Based on Cloud Theory

This research presents a new application of the cloud theory-based simulated annealing algorithm to solve mixed model assembly line sequencing problems where line stoppage cost is expected to be optimized. This objective is highly significant in mixed model assembly line sequencing problems based on just-in-time production system. Moreover, this type of problem is NP-hard and solving this problem through some classical approaches such as total enumeration or exact mathematical procedures such as dynamic programming is computationally prohibitive. Therefore, we proposed the cloud theory-based simulated annealing algorithm (CSA) to address it. Previous researches indicates that evolutionary algorithms especially simulated annealing (SA) is an appropriate method to solve this problem; so we compared CSA with SA in this study to validate the proposed CSA algorithm. Experimentation shows that the CSA approach outperforms the SA approach in both CPU time and objective function especially in large size problems.</p

Nerve growth factor (NGF) has an anti-tumor effects through perivascular innervation of neovessels in HT1080 fibrosarcoma and HepG2 hepatitis tumor in nude mice

This study investigated whether NGF prevents tumor growth by promoting neuronal regulation of tumor blood flow. HT1080 fibrosarcoma cells or HepG2 hepatitis cells were subcutaneously implanted into nude mice. On Day 21 after the implantation of tumor cells, human NGF (40 or 80 ng/h for 14 days) was administered using a micro-osmotic pump. Growth rates of both tumors were significantly inhibited by the treatment of NGF, and the survival rate was also extended. Significant suppression of HT1080 tumor growth lasted after withdrawing NGF. NGF markedly increased the density of α-smooth muscle actin (α-SMA)-immunoreactive (ir) cells without changing neovessel density in HT1080 tumor tissues. Double immunostaining demonstrated protein gene product (PGP) 9.5-ir nerves around α-SMA-ir cells were found in HT1080 tumor tissue treated with NGF. The blood flow in HepG2 tumors treated with saline was significantly higher than in the non-tumor control area, but the tumor blood flow was markedly reduced by NGF treatment. In in vitro studies, NGF significantly accelerated migration of aortic smooth muscle cells but not endothelial cells, whereas NGF had no cytotoxic action on both cells. NGF inhibits tumor growth via indirect action, probably through innervation and maturation of tumor neovasculature, which regulates blood flow into tumor tissues