Performing temporal processes

This article explores the way that the performance of temporal processes in recent contemporary music reveals something about the nature of musical time. Process music deals with time as a part of its material, offering the opportunity to experience time as time: the expression and experience of units of time that are defined by, and enclose, processes, in works whose forms are defined by their durations. The nature of time in four examples, by Alistair Zaldua, Mathias Spahlinger, Steve Gisby, and Sophie Stone, is discussed with reference to theories of time by Jonathan D. Kramer and Henri Bergson

Nucleation and Crystallization of PA6 Composites Prepared by T-RTM: Effects of Carbon and Glass Fiber Loading

Thermoplastic resin transfer molding (T-RTM) is attracting much attention due to the need for recyclable alternatives to thermoset materials. In this work, we have prepared polyamide-6 (PA6) and PA6/fiber composites by T-RTM of caprolactam. Glass and carbon fibers were employed in a fixed amount of 60 and 47 wt.%, respectively. Neat PA6 and PA6 matrices (of PA6-GF and PA6-CF) of approximately 200 kg/mol were obtained with conversion ratios exceeding 95%. Both carbon fibers (CF) and glass fibers (GF) were able to nucleate PA6, with efficiencies of 44% and 26%, respectively. The α crystal polymorph of PA6 was present in all samples. The lamellar spacing, lamellar thickness and crystallinity degree did not show significant variations in the samples with or without fibers as result of the slow cooling process applied during T-RTM. The overall isothermal crystallization rate decreased in the order: PA6-CF > PA6-GF > neat PA6, as a consequence of the different nucleation efficiencies. The overall crystallization kinetics data were successfully described by the Avrami equation. The lamellar stack morphology observed by atomic force microscopy (AFM) is consistent with 2D superstructural aggregates (n = 2) for all samples. Finally, the reinforcement effect of fibers was larger than one order of magnitude in the values of elastic modulus and tensile strength.We gratefully acknowledge the Basque Government by the funding received through the ELKARTEK 2017 Cooperative Fundamental Research project: ”Automotion Composites fabricated by RTM adapted to the 4.0 industrial philosophy (RTM4.0). The authors thank the ALBA Synchrotron Light facility for supporting the X-rays experiments at beamline BL11-NCD-SWEET and the funding by ALBA project nº 2017092338. The UPV/EHU team gratefully acknowledges the financial contribution of the Basque Government through grant IT1309-19

Pla funcional del Programa d’incorporació de fisioterapeutes a l’atenció primària i comunitària: programa d’incorporació de fisioterapeutes per a la promoció del funcionament i la prevenció de la discapacitat a l’atenció primària i comunitària

Fisioterapeutes; Atenció primària; IncorporacióFisioterapeutas; Atención primaria; IncorporaciónPhysiotherapists; Primary care; IncorporationEl present pla funcional és una eina de suport per a l’acollida i la incorporació dels nous fisioterapeutes1 d’atenció primària i comunitària (FisioAPiC) als equips d’atenció primària (EAP) d’arreu de Catalunya. Aquest és un document dinàmic que requerirà les aportacions dels professionals dels EAP que han incorporat aquest nou rol per tal de fer-lo evolucionar i enriquir-lo en les versions següents

Suicidal behavior in depressive disorder: an event-related potential study.

P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results showed a significant reduction of P200, P300, and CNV and a significant increase of postimperative negative variation (PINV) in patients who had attempted suicide compared to patients with a negative history. Moreover, P300 amplitude was negatively related with the Suicidal Risk and the Hopelessness but not with the Hamilton scales. These results stress the need to differentiate clinical subgroups of patients to assess the psychophysiology of depression, and indicate that patients who attempted suicide exhibit lower cortical resources and poorer cortical performance than patients without history of suicide attempt

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4

Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer’s disease (AD) patients independent of any effects on hypertension. However, studies in rodent models directly testing the activity of ARB treatment on behavior and AD-relevent pathology including neuroinflammation, Aβ levels, and cerebrovascular function, have produced mixed results. APOE4 is a major genetic risk factor for AD and has been linked to many of the same functions as those purported to be modulated by ARB treatment. Therefore, evaluating the effects of ARB treatment on behavior and AD-relevant pathology in mice that express human APOE4 could provide important information on whether to further develop ARBs for AD therapy. In this study, we treated female and male mice that express the human APOE4 gene in the absence (E4FAD−) or presence (E4FAD+) of high Aβ levels with the ARB prodrug candesartan cilexetil for a duration of 4 months. Compared to vehicle, candesartan treatment resulted in greater memory-relevant behavior and higher hippocampal presynaptic protein levels in female, but not male, E4FAD− and E4FAD+ mice. The beneficial effects of candesartan in female E4FAD− and E4FAD+ mice occurred in tandem with lower GFAP and Iba1 levels in the hippocampus, whereas there were no effects on markers of cerebrovascular function and Aβ levels. Collectively, these data imply that the effects of ARBs on AD-relevant pathology may be modulated in part by the interaction between APOE genotype and biological sex. Thus, the further development of ARBs could provide therapeutic options for targeting neuroinflammation in female APOE4 carriers. © Copyright © 2021 Scheinman, Zaldua, Dada, Krochmaliuk, Dye, Marottoli, Thatcher and Tai.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Accelerating sustainable and economic development via industrial energy cooperation and shared services – A case study for three European countries

The European industry sector is responsible for about one-third of the EU's total energy consumption and process-related Greenhouse Gas emissions, which makes it a central factor in the EU's climate and energy strategies. Energy cooperation, i.e., the mutualised generation, use and/or acquisition of energy by at least two companies, has the potential of significantly supporting the successful achievement of these strategies. This paper presents a concept for moving from a single-company sustainable energy intervention approach to cooperative sustainable energy solutions within the framework of industrial parks. Technical, economic, regulatory, organizational, and social barriers for energy-efficient park design and operation on all levels and instruments to overcome them have been systematically analysed, taking correlation of solutions, and park-specific requirements into account, thus providing a holistic workflow. First results show that technical and economic attractiveness, and an enabling legal and policy context, are not always enough. For promising energy cooperation solutions to flourish, cultural, organizational, social, and behavioural factors also play a significant role. Furthermore, findings show that external facilitators are helpful to pool efforts to achieve greater engagement

Additional file 1 of High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Additional file 1. Supplementary methods

Additional file 2 of High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Additional file 2. Table S1. Relationships between sRAGE, NEWS2 and IL-6. Table S2. Univariate analysis for potential predictors of mortality in dexamethasone-treated COVID-19 patients. Table S3. Performance of sRAGE and NEWS2 in their ability to predict mortality in dexamethasone-treated COVID-19 patient