Health Impacts of Noise Pollution Around Airports: Economic Valuation and Transferability

Air transportation generates numerous economic and social welfare benefits. Airports and their expansions are associated with direct, indirect, induced effects as well as catalytic impacts on regional and national economies (Arndt et al., 2009; Braun et al., 2010). Mobility and accessibility are important factors determining competitiveness of (regional and national) economies in an increasingly globalised world. On the other hand there are numerous environmental and health impacts related to the growing demand for air transport. Since the projected annual growth rates of numbers of passengers are about 5% in the next 20 to 25 years (Mahashabde et al., 2011), the continuing growth of the aviation sector has raised questions of appropriate valuation and treatment of external costs (e.g. human and environmental health). In the context of transport markets, a distinction of externalities into positive (external benefits) and negative (external costs) is appropriate. Large infrastructure projects like airports cause various external effects, associated especially with the provision of transport services and facilities, the need of constructing transport infrastructure as well as related production of vehicles or raw materials (Schipper et al. 2001). Air traffic and associated ground side traffic contribute to local and global noise and air pollution

Evaluating the Utah Agriculture in the Classroom Preservice Teacher Seminar

Utah Agriculture in the Classroom hosts preservice teacher seminars in partnership with five universities across the state. From 2017-2021, approximately 600 college students participated in these seminars. The preservice seminars provided agriculture-themed lessons aligned to state educational standards for future teachers to use as they build resources for their classrooms

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy.

We delineate a KMT2E-related neurodevelopmental disorder on the basis of 38 individuals in 36 families. This study includes 31 distinct heterozygous variants in KMT2E (28 ascertained from Matchmaker Exchange and three previously reported), and four individuals with chromosome 7q22.2-22.23 microdeletions encompassing KMT2E (one previously reported). Almost all variants occurred de novo, and most were truncating. Most affected individuals with protein-truncating variants presented with mild intellectual disability. One-quarter of individuals met criteria for autism. Additional common features include macrocephaly, hypotonia, functional gastrointestinal abnormalities, and a subtle facial gestalt. Epilepsy was present in about one-fifth of individuals with truncating variants and was responsive to treatment with anti-epileptic medications in almost all. More than 70% of the individuals were male, and expressivity was variable by sex; epilepsy was more common in females and autism more common in males. The four individuals with microdeletions encompassing KMT2E generally presented similarly to those with truncating variants, but the degree of developmental delay was greater. The group of four individuals with missense variants in KMT2E presented with the most severe developmental delays. Epilepsy was present in all individuals with missense variants, often manifesting as treatment-resistant infantile epileptic encephalopathy. Microcephaly was also common in this group. Haploinsufficiency versus gain-of-function or dominant-negative effects specific to these missense variants in KMT2E might explain this divergence in phenotype, but requires independent validation. Disruptive variants in KMT2E are an under-recognized cause of neurodevelopmental abnormalities