58 research outputs found
Fully differential W' production and decay at next-to-leading order in QCD
We present the fully differential production and decay of a W' boson, with
arbitrary vector and axial-vector couplings, to any final state at
next-to-leading order in QCD. We demonstrate a complete factorization of
couplings at next-to-leading order in both the partial width of the W' boson,
and in the full two-to-two cross section. We provide numerical predictions for
the contribution of a W' boson to single-top-quark production, and separate
results based on whether the mass of the right-handed neutrino (nu_R) is light
enough for the leptonic decay channel to be open. The single-top-quark analysis
will allow for an improved direct W' mass limit of 525-550 GeV using data from
run I of the Fermilab Tevatron. We propose a modified tolerance method for
estimating parton distribution function uncertainties in cross sections.Comment: 23 pages, revtex3, 13 ps fig
Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target for glaucoma therapy. Our study helps to better understand underlying genetic and molecular mechanisms that regulate intraocular pressure, and identifies a new candidate gene, Cacna2d1, that modulates intraocular pressure and a promising therapeutic, pregabalin, which binds to CACNA2D1 protein and lowers intraocular pressure significantly. Because our study utilizes a genetically diverse population of mice with kno
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 Ă 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation
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