Biomass Production of the EDEN ISS Space Greenhouse in Antarctica During the 2018 Experiment Phase

The EDEN ISS greenhouse is a space-analog test facility near the German Neumayer III station in Antarctica. The facility is part of the project of the same name and was designed and built starting from March 2015 and eventually deployed in Antarctica in January 2018. The nominal operation of the greenhouse started on February 7th and continued until the 20th of November. The purpose of the facility is to enable multidisciplinary research on topics related to future plant cultivation on human space exploration missions. Research on food quality and safety, plant health monitoring, microbiology, system validation, human factors and horticultural sciences was conducted. Part of the latter is the determination of the biomass production of the different crops. The data on this topic is presented in this paper. During the first season 26 different crops were grown on the 12.5 m2 cultivation area of the greenhouse. A large number of crops were grown continuously throughout the 9 months of operation, but there were also crops that were only grown a few times for test purposes. The focus of this season was on growing lettuce, leafy greens and fresh vegetables. In total more than 268 kg of edible biomass was produced by the EDEN ISS greenhouse facility in 2018. Most of the harvest was cucumbers (67 kg), lettuces (56 kg), leafy greens (49 kg), and tomatoes (50 kg) complemented with smaller amounts of herbs (12 kg), radish (8 kg), and kohlrabi (19 kg). The environmental set points for the crops were 330–600 µmol/(m2∗s) LED light, 21◦C, ∼65% relative humidity, 1000 ppm and the photoperiod was 17 h per day. The overall yearly productivity of the EDEN ISS greenhouse in 2018 was 27.4 kg/m2, which is equal to 0.075 kg/(m2∗d). This paper shows in detail the data on edible and inedible biomass production of each crop grown in the EDEN ISS greenhouse in Antarctica during the 2018 season

Potential drug-drug interactions in patients with indication for prophylactic implantation of a cardioverter defibrillator: a cross-sectional analysis

Background: Due to demographic transition, multimorbidity and high numbers of medicinal products, polypharmacy rates will presumably further increase. This could lead to higher risks of potentially inappropriate medications with potential drug-drug interactions (PDDI). PDDI has already been investigated by several studies, but not for patients with indication for prophylactic implantation of a cardioverter defibrillator (ICD). Thus, the objective of this analysis was to examine the frequency of PDDI in that specific group of patients and compare patients with or without PDDI regarding potential underlying factors. Methods: Cross-sectional data analyses were performed using data of the prospective EU-CERT-ICD study that primarily aimed to assess ICD effectiveness in Europe. Self-reported baseline medication data of patients from Germany and Switzerland were used. Patients who reported to take at least two drugs simultaneously for at least 80 days were defined as population at risk. By means of a publicly available interaction checker, we analyzed the medication data regarding occurrence and characteristics of PDDI categorized as minor, moderate, and major PDDI. The analyses were done using descriptive methods and chi square testing. Results: The total population (n = 524) and the population at risk (n = 383) were rather similar with an average age of 64 years and about 80% male. PDDIs were found for 296 patients (in 57% of total population vs. 77% of population at risk). The moderate PDDI category was most frequently with 268 affected patients. Comparing patients with and without any PDDI, the proportion of patients with place of residence in Germany varied distinctly (93% vs. 78%). The frequency of any PDDI for the total population was twice as high in Germany as in Switzerland (p value < 0.001). Conclusions: PDDIs were frequently observed in this selected patient population and differed markedly between German and Swiss patients. The results should lead to higher awareness of polypharmacy and PDDIs. Adequate cooperation between health care providers should be promoted and new technologies such as drug interaction information systems or digital patient files used. Trial registration: The EU-CERT-ICD study is registered at www.clinicaltrials.gov (NCT02064192)

Sudden increase in Antarctic sea ice: Fact or artifact?

Copyright © 2011 American Geophysical UnionThree sea ice data sets commonly used for climate research display a large and abrupt increase in Antarctic sea ice area (SIA) in recent years. This unprecedented change of SIA is diagnosed to be primarily caused by an apparent sudden increase in sea ice concentrations within the ice pack, especially in the area of the most-concentrated ice (greater than 95% concentration). A series of alternative satellite-derived records do not display any abnormal sudden SIA changes, but do reveal substantial discrepancies between different satellite sensors and sea ice algorithms. Sea ice concentrations in the central ice pack and SIA values derived from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSRE) are consistently greater than those derived from the Special Sensor Microwave Imager (SSMI). A switch in source data from the SSMI to AMSRE in mid-2009 explains most of the SIA increase in all three affected data sets. If uncorrected for, the discontinuity artificially exaggerates the winter Antarctic SIA increase (1979–2010) by more than a factor of 2 and the spring trend by almost a factor of 4. The discontinuity has a weaker influence on the summer and autumn SIA trends, on calculations of Antarctic sea ice extent, and in the Arctic

Natriuretic peptides for the detection of paroxysmal atrial fibrillation

Background and purpose: Silent atrial fibrillation (AF) and tachycardia (AT) are considered precursors of ischaemic stroke. Therefore, detection of paroxysmal atrial rhythm disorders is highly relevant, but is clinically challenging. We aimed to evaluate the diagnostic value of natriuretic peptide levels in the detection of paroxysmal AT/AF in a pilot study. Methods: Natriuretic peptide levels were analysed in two independent patient cohorts (162 patients with arterial hypertension or other cardiovascular risk factors and 82 patients with retinal vessel disease). N-terminal-pro-brain natriuretic peptide (NT-proBNP) and BNP were measured before the start of a 7-day Holter monitoring period carefully screened for AT/AF. Results: 244 patients were included; 16 had paroxysmal AT/AF. After excluding patients with a history of AT/AF (n=5), 14 patients had newly diagnosed AT/AF (5.8%) NT-proBNP and BNP levels were higher in patients with paroxysmal AT/AF in both cohorts: (1) 154.4 (IQR 41.7; 303.6) versus 52.8 (30.4; 178.0) pg/mL and 70.0 (31.9; 142.4) versus 43.9 (16.3; 95.2) and (2) 216.9 (201.4; 277.1) versus 90.8 (42.3–141.7) and 96.0 (54.7; 108.2) versus 29.1 (12.0; 58.1). For the detection of AT/AF episodes, NT-proBNP and BNP had an area under the curve in receiver operating characteristic analysis of 0.76 (95% CI, 0.64 to 0.88; p=0.002) and 0.75 (0.61 to 0.89; p=0.004), respectively. Conclusions: NT-proBNP and BNP levels are elevated in patients with silent AT/AF as compared with sinus rhythm. Thus, screening for undiagnosed paroxysmal AF using natriuretic peptide level initiated Holter monitoring may be a useful strategy in prevention of stroke or systemic embolism

Summary of Research and Outreach Activities during the 2021 Season of the EDEN ISS Antarctic Greenhouse

THE EDEN ISS greenhouse is a space-analogue test facility near the German Neumayer Station III (NM-III) in Antarctica. The greenhouse design, construction, and test phase began in 2015, and the facility was shipped to NM-III in January 2018. From 2018 until early 2022, the greenhouse was in continuous operation during every winter-over period, with the 2021 season being the latest to be completed. The purpose of the facility is to enable multidisciplinary research on topics related to plant cultivation on future human space exploration missions. Research on food quality and safety, plant health monitoring, microbiology, system validation, human factors, horticultural sciences, and resource demand was conducted. During the 2021 season, research and operation of the EDEN ISS greenhouse was done as part of a DLR-NASA collaboration with an American on-site operator. Part of this collaboration was testing new crops like chili pepper, broccoli, cauliflower, and beans, which had never been grown inside EDEN ISS. These crops were complemented by a variety of lettuces, mustard greens, herbs, tomatoes, cucumbers, radishes, and kohlrabi. In total, approximately 315 kg of fresh produce was harvested during the 2021 season, which was supplied to the NM-III wintering crew. Frozen and dried plant subsamples were collected and transferred back to Europe and the United States for further investigation. Additional samples were taken from the nutrient delivery subsystem and from surfaces inside the EDEN ISS facility in order to continue the microbiological research activities from previous years. Another research focus was capturing crew time for all activities inside the MTF and select support activities inside NM-III to increase the understanding of work time demand for future food production systems in space. DLR and NASA also continued the numerous outreach activities of the past years. This paper summarizes both the research and the outreach activities during the latest operational season of the EDEN ISS Antarctic greenhouse in 2021

EDEN ISS - Greenhouse in Antarctica

Ant-Land Status Report describing activities and preliminary results of the 2020 Antarctic winter season and the 2020/21 Antarctic summer seaso

Die Webvideo-Branche in Deutschland: Wirtschaftliche Struktur und Entwicklung der Standorte

Die Nutzung von Online-Videos nimmt immer weiter zu und eröffnet neuen Akteuren den Eintritt in diesen, sich entwickelnden Markt. Mediencluster können diesen Trend nutzen, indem sie versuchen, einige dieser neuen Akteure anzuziehen. Gleichwohl ist die Standortentscheidung von Online-Video-Produzenten bisher kaum untersucht. Um mögliche Webvideo-Cluster zu identifizieren, die Struktur der Branche zu untersuchen und Faktoren für die Standortentscheidung aufzudecken, wurden 2.130 Webvideo-Unternehmen, die deutsch- oder englischsprachige Videos auf YouTube, Facebook, Instagram oder Twitch in Deutschland distribuieren, erfasst und befragt. Die meisten Webvideo-Unternehmen haben ihren Sitz in Berlin, Köln, Hamburg oder München. 60 Prozent der Unternehmen agieren als Einzelunternehmer/in (bzw. als Privatperson) und ein Großteil arbeitet kostendeckend bzw. mit einem Gewinnüberschuss. Die räumliche Nähe zur Kreativ- und Medienwirtschaft und die Verfügbarkeit medientechnischer Mitarbeiter am Standort sowie ein urbanes Umfeld und eine gute Infrastruktur sind die wichtigsten Standortfaktoren für die Webvideo-Unternehmen

Crew time and workload in the EDEN ISS greenhouse in Antarctica

The goal of the EDEN ISS project is to research technologies for future greenhouses as a substantial part of planetary surface habitats. In this paper, we investigate crew time and workload needed to operate the space analogue EDEN ISS greenhouse on-site and remotely from the Mission Control Center. Within the almost three years of operation in Antarctica, different vegetable crops were cultivated, which yielded an edible biomass of 646 kg during the experiment phase 2018 and 2019. Operating in such a remote environment, analogue to future planetary missions, both greenhouse systems and remote support capabilities must be carefully developed and assessed to guarantee a reliable and efficient workflow. The investigation of crew time and workload is crucial to optimize processes within the operation of the greenhouse. For the Antarctic winter seasons, 2019 and 2020, as well as the summer season 2019/2020, the workload of the EDEN ISS greenhouse operators was assessed using the NASA Task Load Index. In addition, crew time was measured for the winter season 2019. The participants consisted of on-site operators, who worked inside the EDEN ISS greenhouse in Antarctica and the DLR remote support team, who worked in the Mission Control Center at the DLR Institute of Space Systems in Bremen (Germany). The crew time results show that crew time for the whole experiment phase 2019 required by the on-site operator team 2019 is approximately four times higher than the crew time of the corresponding remote support team without considering planning activities for the next mission. The total crew time for the experiment phase 2019 amounts to 694.5 CM-h or 6.31 CM-h/kg. With the measurements of the experiment phase 2019 it was possible to develop a methodology for crew time categorization for the remote support activities, which facilitates the analysis and increases the comparability of crew time values. In addition, the development of weekly and monthly crew time demand over the experiment phase is presented. The workload investigations indicate that the highest workload is perceived by the remote support team 2019 + 2020, followed by the summer maintenance team 2019/2020. The on-site operator team 2019 and on-site operator team 2020 showed the lowest values. The values presented in this paper indicate the need to minimize crew time as well as workload demands of the operators involved in the operation of future planetary surface greenhouses

QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators.

OBJECTIVE To test the hypothesis that in recipients of primary prophylactic implantable cardioverter-defibrillators (ICDs), the non-planarity of ECG vector loops predicts (a) deaths despite ICD protection and (b) appropriate ICD shocks. METHODS Digital pre-implant ECGs were collected in 1948 ICD recipients: 21.4% females, median age 65 years, 61.5% ischaemic heart disease (IHD). QRS and T wave three-dimensional loops were constructed using singular value decomposition that allowed to measure the vector loop planarity. The non-planarity, that is, the twist of the three-dimensional loops out of a single plane, was related to all-cause mortality (n=294; 15.3% females; 68.7% IHD) and appropriate ICD shocks (n=162; 10.5% females; 87.7% IHD) during 5-year follow-up after device implantation. Using multivariable Cox regression, the predictive power of QRS and T wave non-planarity was compared with that of age, heart rate, left ventricular ejection fraction, QRS duration, spatial QRS-T angle, QTc interval and T-peak to T-end interval. RESULTS QRS non-planarity was significantly (p<0.001) associated with follow-up deaths despite ICD protection with HR of 1.339 (95% CI 1.165 to 1.540) but was only univariably associated with appropriate ICD shocks. Non-planarity of the T wave loop was the only ECG-derived index significantly (p<0.001) associated with appropriate ICD shocks with multivariable Cox regression HR of 1.364 (1.180 to 1.576) but was not associated with follow-up mortality. CONCLUSIONS The analysed data suggest that QRS and T wave non-planarity might offer distinction between patients who are at greater risk of death despite ICD protection and those who are likely to use the defibrillator protection