Transbronchial biopsy results according to diffuse interstitial lung disease classification. Cryobiopsy versus forceps: MULTICRIO study

Background In recent years, transbronchial cryobiopsy (TBCB) has come to be increasingly used in interventional pulmonology units as it obtains larger and better-quality samples than conventional transbronchial lung biopsy (TBLB) with forceps. No multicenter studies have been performed, however, that analyse and compare TBCB and TBLB safety and yield according to the interstitial lung disease (ILD) classification. Objectives We compared the diagnostic yield and safety of TBCB with cryoprobe sampling versus conventional TBLB forceps sampling in the same patient. Method Prospective multicenter clinical study of patients with ILD indicated for lung biopsy. Airway management with orotracheal tube, laryngeal mask and rigid bronchoscope was according to the protocol of each centre. All procedures were performed using fluoroscopy and an occlusion balloon. TBLB was followed by TBCB. Complications were recorded after both TBLB and TBCB. Results Included were 124 patients from 10 hospitals. Airway management was orotracheal intubation in 74% of cases. Diagnostic yield according to multidisciplinary committee results for TBCB was 47.6% and for TBLB was 19.4% (p<0.0001). Diagnostic yield was higher for TBCB compared to TBLB for two groups: idiopathic interstitial pneumonias (IIPs) and ILD of known cause or association (OR 2.5; 95% CI: 1.4-4.2 and OR 5.8; 95% CI: 2.3-14.3, respectively). Grade 3 (moderate) bleeding after TBCB occurred in 6.5% of patients compared to 0.8% after conventional TBLB. Conclusions Diagnostic yield for TBCB was higher than for TBLB, especially for two disease groups: IIPs and ILD of known cause or association. The increased risk of bleeding associated with TBCB confirms the need for safe airway management and prophylactic occlusion-balloon use. Trial registration clinicaltrials.gov identifier: NCT02464592

Effects of different resistance training volumes on strength and power in team sport athletes

The aim of this study was to compare the effects of 3 different volume of resistance training (RT) on maximum strength and average power in college team sport athletes with no previous RT experience. Thirty-two subjects (20 men and 12 women, age = 23.1 ± 1.57 years) were randomly divided into 4 groups: low volume (LV; n = 8), 1 set per exercise and 3 sets per muscle group; moderate volume (MV; n = 8), 2 sets per exercise and 6 sets per muscle group; high volume (HV; n = 8), 3 sets per exercise and 9 sets per muscle group; and a non-RT control group (n = 8). The 3 intervention groups were trained for 6 weeks thrice weekly after a nonperiodized RT program differentiated only by the volume. Before (T1) and after training (T2), 1 repetition maximum (1RM) and maximal average power (AP) produced on the bench press (BP), upright row (UR), and squat (SQ) were assessed by progressive resistance tests. One repetition maximum-BP and 1RM-UR increased significantly in the 3 interventions groups (p 0.20 < 0.60) were observed for the 1RM-BP and 1RM-UR in the 3 training groups. High-volume group showed the larger ES for 1RM-BP (0.45), 1RM-UR (0.60), and 1RM-SQ (0.47), whereas the LV produced the higher ES for SQ-AP (0.53). During the initial adaptation period, a HV RT program seems to be a better strategy for improving strength, whereas during the season, an LV RT could be a reasonable option for maintaining strength and enhancing lower-body AP in team sport athletes