Advances in All-Neural Speech Recognition

This paper advances the design of CTC-based all-neural (or end-to-end) speech recognizers. We propose a novel symbol inventory, and a novel iterated-CTC method in which a second system is used to transform a noisy initial output into a cleaner version. We present a number of stabilization and initialization methods we have found useful in training these networks. We evaluate our system on the commonly used NIST 2000 conversational telephony test set, and significantly exceed the previously published performance of similar systems, both with and without the use of an external language model and decoding technology

Tetraquark spectroscopy

A complete classification of tetraquark states in terms of the spin-flavor, color and spatial degrees of freedom was constructed. The permutational symmetry properties of both the spin-flavor and orbital parts of the quark-quark and antiquark-antiquark subsystems are discussed. This complete classification is general and model-independent, and is useful both for model-builders and experimentalists. The total wave functions are also explicitly constructed in the hypothesis of ideal mixing; this basis for tetraquark states will enable the eigenvalue problem to be solved for a definite dynamical model. This is also valid for diquark-antidiquark models, for which the basis is a subset of the one we have constructed. An evaluation of the tetraquark spectrum is obtained from the Iachello mass formula for normal mesons, here generalized to tetraquark systems. This mass formula is a generalizazion of the Gell-Mann Okubo mass formula, whose coefficients have been upgraded by means of the latest PDG data. The ground state tetraquark nonet was identified with $f_{0}(600)$, $\kappa(800)$, $f_{0}(980)$, $a_{0}(980)$. The mass splittings predicted by this mass formula are compared to the KLOE, Fermilab E791 and BES experimental data. The diquark-antidiquark limit was also studied.Comment: Invited talk at 11th International Conference on Meson-Nucleon Physics and the Structure of the Nucleon (MENU 2007), Julich, Germany, 10-14 Sep 2007. In the Proceedings of 11th International Conference on Meson-Nucleon Physics and the Structure of the Nucleon (MENU 2007), Julich, Germany, 10-14 Sep 2007, eConf C070910, 163 (2007

The Symmetries of Nature

The study of the symmetries of nature has fascinated scientists for eons. The application of the formal mathematical description of symmetries during the last century has produced many breakthroughs in our understanding of the substructure of matter. In this talk, a number of these advances are discussed, and the important role that George Sudarshan played in their development is emphasize

Development of a documentation instrument for the conservative treatment of spinal disorders in the International Spine Registry, Spine Tango

Spine Tango is the first and only International Spine Registry in operation to date. So far, only surgical spinal interventions have been recorded and no comparable structured and comprehensive documentation instrument for conservative treatments of spinal disorders is available. This study reports on the development of a documentation instrument for the conservative treatment of spinal disorders by using the Delphi consensus method. It was conducted with a group of international experts in the field. We also assessed the usability of this new assessment tool with a prospective feasibility study on 97 outpatients and inpatients with low back or neck pain undergoing conservative treatment. The new ‘Spine Tango conservative' questionnaire proved useful and suitable for the documentation of pathologies, conservative treatments and outcomes of patients with low back or neck problems. A follow-up questionnaire seemed less important in the predominantly outpatient setting. In the feasibility study, between 43 and 63% of patients reached the minimal clinically important difference in pain relief and Core Outcome Measures Index at 3months after therapy; 87% of patients with back pain and 85% with neck pain were satisfied with the received treatment. With ‘Spine Tango conservative' a first step has been taken to develop and implement a complementary system for documentation and evaluation of non-surgical spinal interventions and outcomes within the framework of the International Spine Registry. It proved useful and feasible in a first pilot study, but it will take the experience of many more cases and therapists to develop a version similarly mature as the surgical instruments of Spine Tang

Physician Willingness to Withhold Tube Feeding after Cruzan: An Empirical Study

In Cruzan v. Hannon, the Missouri Supreme Court declined to let Nancy Cruzan\u27s father discontinue her tube feedings. The court insisted on clear and convincing evidence of her wishes and was unsatisfied that proof of this kind had been presented in her case.\u27 In addition, it refused to defer to her family or to consider her quality of life. On June 25, 1990, the United States Supreme Court affirmed the Missouri Supreme Court\u27s decision. Since Cruzan, public demand for living wills has exploded

SWISSspine: a nationwide registry for health technology assessment of lumbar disc prostheses

SWISSspine is a so-called pragmatic trial for assessment of safety and efficiency of total disc arthroplasty (TDA). It follows the new health technology assessment (HTA) principle of "coverage with evidence development”. It is the first mandatory HTA registry of its kind in the history of Swiss orthopaedic surgery. Its goal is the generation of evidence for a decision by the Swiss federal office of health about reimbursement of the concerned technologies and treatments by the basic health insurance of Switzerland. During the time between March 2005 and 2008, 427 interventions with implantation of 497 lumbar total disc arthroplasties have been documented. Data was collected in a prospective, observational multicenter mode. The preliminary timeframe for the registry was 3years and has already been extended. Data collection happens pre- and perioperatively, at the 3months and 1-year follow-up and annually thereafter. Surgery, implant and follow-up case report forms are administered by spinal surgeons. Comorbidity questionnaires, NASS and EQ-5D forms are completed by the patients. Significant and clinically relevant reduction of low back pain VAS (70.3-29.4 points preop to 1-year postop, p<0.0001) leg pain VAS (55.5-19.1 points preop to 1-year postop, p<0.001), improvement of quality of life (EQ-5D, 0.32-0.73 points preop to 1-year postop, p<0.001) and reduction of pain killer consumption was revealed at the 1-year follow-up. There were 14 (3.9%) complications and 7 (2.0%) revisions within the same hospitalization reported for monosegmental TDA; there were 6 (8.6%) complications and 8 (11.4%) revisions for bisegmental surgery. There were 35 patients (9.8%) with complications during followup in monosegmental and 9 (12.9%) in bisegmental surgery and 11 (3.1%) revisions with new hospitalization in monosegmental and 1 (1.4%) in bisegmental surgery. Regression analysis suggested a preoperative VAS "threshold value” of about 44 points for increased likelihood of a minimum clinically relevant back pain improvement. In a short-term perspective, lumbar TDA appears as a relatively safe and efficient procedure concerning pain reduction and improvement of quality of life. Nevertheless, no prediction about the long-term goals of TDA can be made yet. The SWISSspine registry proofs to be an excellent tool for collection of observational data in a nationwide framework whereby advantages and deficits of its design must be considered. It can act as a model for similar projects in other health-care domain

Effect of carbohydrate feeding on the bone metabolic response to running

Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses to carbohydrate (CHO) feeding during treadmill running. Ten men completed two 7-day trials, once being fed CHO (8% glucose immediately before, every 20 min during, and immediately after exercise at a rate of 0.7 g CHO·kg body mass-1·h-1) and once being fed placebo (PBO). On day 4 of each trial, participants completed a 120-min treadmill run at 70% of maximal oxygen consumption (VO2 max). Blood was taken at baseline (BASE), immediately after exercise (EE), after 60 (R1) and 120 (R2) min of recovery, and on three follow-up days (FU1-FU3). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH2-terminal propeptides of procollagen type 1 (P1NP)] were measured, along with osteocalcin (OC), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate, glucagon-like peptide-2 (GLP-2), interleukin-6 (IL-6), insulin, cortisol, leptin, and osteoprotogerin (OPG). Area under the curve was calculated in terms of the immediate (BASE, EE, R1, and R2) and short-term (BASE, FU1, FU2, and FU3) responses to exercise. β-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (β-CTX: P=0.028; P1NP: P=0.021; IL-6: P=0.036), although there was no difference in the short-term response (β-CTX: P=0.856; P1NP: P=0.721; IL-6: P=0.327). No other variable was significantly affected by CHO feeding during exercise. We conclude that CHO feeding during exercise attenuated the β-CTX and P1NP responses in the hours but not days following exercise, indicating an acute effect of CHO feeding on bone turnover

The power of Bayesian evidence in astronomy

We discuss the use of the Bayesian evidence ratio, or Bayes factor, for model selection in astronomy. We treat the evidence ratio as a statistic and investigate its distribution over an ensemble of experiments, considering both simple analytical examples and some more realistic cases, which require numerical simulation. We find that the evidence ratio is a noisy statistic, and thus it may not be sensible to decide to accept or reject a model based solely on whether the evidence ratio reaches some threshold value. The odds suggested by the evidence ratio bear no obvious relationship to the power or Type I error rate of a test based on the evidence ratio. The general performance of such tests is strongly affected by the signal to noise ratio in the data, the assumed priors, and the threshold in the evidence ratio that is taken as `decisive'. The comprehensiveness of the model suite under consideration is also very important. The usefulness of the evidence ratio approach in a given problem can be assessed in advance of the experiment, using simple models and numerical approximations. In many cases, this approach can be as informative as a much more costly full-scale Bayesian analysis of a complex problem.Comment: 11 pages; MNRAS in pres

How to Tango: a manual for implementing Spine Tango

The generic approach of the Spine Tango documentation system, which uses web-based technologies, is a necessity for reaching a maximum number of participants. This, in turn, reduces the potential for customising the Tango according to the individual needs of each user. However, a number of possibilities still exist for tailoring the data collection processes to the user's own hospital workflow. One can choose between a purely paper-based set-up (with in-house scanning, data punching or mailing of forms to the data centre at the University of Bern) and completely paper-free online data entry. Many users work in a hybrid mode with online entry of surgical data and paper-based recording of the patients' perspectives using the Core Outcome Measures Index (COMI) questionnaires. Preoperatively, patients can complete their questionnaires in the outpatient clinic at the time of taking the decision about surgery or simply at the time of hospitalisation. Postoperative administration of patient data can involve questionnaire completion in the outpatient clinic, the handing over the forms at the time of discharge for their mailing back to the hospital later, sending out of questionnaires by post with a stamped addressed envelope for their return or, in exceptional circumstances, conducting telephone interviews. Eurospine encourages documentation of patient-based information before the hospitalisation period and surgeon-based information both before and during hospitalisation; both patient and surgeon data should be acquired for at least one follow-up, at a minimum of three to six months after surgery. In addition, all complications that occur after discharge, and their consequences should be recorde