Preoccupied by the past - the case of Estonia's Museum of Occupations

The nation is born out of the resistance, ideally without external aid, of its nascent citizens against oppression [...] An effective founding struggle should contain memorable massacres, atrocities, assassinations and the like, which serve to unite and strengthen resistance and render the resulting victory the more justified and the more fulfilling. They also can provide a focus for a "remember the x atrocity" historical narrative.(1

Southern Annular Mode response to volcanic eruptions: implications for ice core proxies

Large tropical volcanic eruptions have been observed to have a significant influence on the large-scale circulation patterns of the Northern Hemisphere, through mechanisms related to the radiative effects of the sulfate aerosols resulting from the volcanic injection of sulfur dioxide into the stratosphere. While no such volcanically induced anomalies in Southern Hemisphere circulation have yet been observed, we find that in general circulation model simulations, eruptions with sulfur dioxide injections larger than that of the 1991 Mt. Pinatubo eruption do result in significant circulation changes in the SH, specifically an enhanced positive phase of the Southern Annular Mode (SAM). We explore the mechanisms for such a SAM response, as well as the corresponding changes in SH temperature, sea ice and precipitation. We also explore how the anomalously strong zonal winds characteristic of the positive SAM regime affect the rate of sulfate deposition to the Antarctic ice-sheet. We suggest that the use of ice-core sulfate records as a proxy for past volcanic activity may benefit from including knowledge of, or better assumptions regarding the changes in large scale atmospheric circulation after large tropical eruptions

FCP

Farmer Consumer Partnerships

Upscaling the housing renovation market through far-reaching industrialization

The European existing building stock contributes to 40% of the total energy use and 36% of the CO2 emissions. To deal with the climate crisis, European climate and energy objectives were defined. By 2050, CO2 emissions should be cut to 80-95% compared to 1990 and all buildings must be energy-neutral. The North-Sea Region alone consists of 22 million outdated dwellings built between 1950 and 1985 that are in high need of renovation. Nowadays, the renovation industry applies mainly manual on-site renovation techniques, resulting in a low renovation pace, relatively high labour costs and a long duration. To tackle the urgent need for rapid renovations, six countries of the North-Sea Region collaborate to upscale the current renovation process in the Interreg project INDU-ZERO "Industrialization of house renovations toward energy-neutral". The project focuses on modular prefabricated renovation packages with fully integrated HVAC technologies to arrive at energy-neutral dwellings. The project researches the possibilities of far-reaching automated and industrialized production processes. A smart factory blueprint will be designed to speed up the renovation pace to a target of 15,000 renovation packages per year per factory while cutting the current price with 50%. This contribution focuses on three main topics: material use, operational energy use and transport. Firstly, the reasoning behind the renovation package design is explained. Next, the packages are adopted on an archetype dwelling to document the thermal performance before and after renovation. Finally, the associated logistics are studied. To summarize each individual research in a blanket result, the environmental impact is determined and compared to the non-renovated dwelling

Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland

The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of life. This development prompted a Swiss expert panel to re-evaluate the current status and formulate updated clinical recommendations for the diagnosis and treatment of plasma cell myeloma. These recommendations should help clinicians in their decision making to achieve the best outcome based on currently available data

Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence

<p>Abstract</p> <p>Objectives</p> <p>To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy.</p> <p>Methods</p> <p>Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk.</p> <p>Results</p> <p>1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer.</p> <p>Conclusions</p> <p>HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections.</p

Agricultural land use changes – a scenario-based sustainability impact assessment for Brandenburg, Germany

AbstractDecisions for agricultural management are taken at farm scale. However, such decisions may well impact upon regional sustainability. Two of the likely agricultural management responses to future challenges are extended use of irrigation and increased production of energy crops. The drivers for these are high commodity prices and subsidy policies for renewable energy. However, the impacts of these responses upon regional sustainability are unknown. Thus, we conducted integrated impact assessments for agricultural intensification scenarios in the federal state of Brandenburg, Germany, for 2025. One Irrigation scenario and one Energy scenario were contrasted with the Business As Usual (BAU) scenario. We applied nine indicators to analyze the economic, social and environmental effects at the regional, in this case district scale, which is the smallest administrative unit in Brandenburg. Assessment results were discussed in a stakeholder workshop involving 16 experts from the state government.The simulated area shares of silage maize for fodder and energy were 29%, 37% and 49% for the BAU, Irrigation, and Energy scenarios, respectively. The Energy scenario increased bio-electricity production to 41% of the demand of Brandenburg, and it resulted in CO2 savings of up to 3.5milliontons. However, it resulted in loss of biodiversity, loss of landscape scenery, increased soil erosion risk, and increased area demand for water protection requirements. The Irrigation scenario led to yield increases of 7% (rapeseed), 18% (wheat, sugar beet), and 40% (maize) compared to the BAU scenario. It also reduced the year-to-year yield variability. Water demand for irrigation was found to be in conflict with other water uses for two of the 14 districts. Spatial differentiation of scenario impacts showed that districts with medium to low yield potentials were more affected by negative impacts than districts with high yield potentials.In this first comprehensive sustainability impact assessment of agricultural intensification scenarios at regional level, we showed that a considerable potential for agricultural intensification exists. The intensification is accompanied by adverse environmental and socio-economic impacts. The novelty lies in the multiscale integration of comprehensive, agricultural management simulations with regional level impact assessment, which was achieved with the adequate use of indicators. It provided relevant evidence for policy decision making. Stakeholders appreciated the integrative approach of the assessment, which substantiated ongoing discussions among the government bodies. The assessment approach and the Brandenburg case study may stay exemplary for other regions in the world where similar economic and policy driving forces are likely to lead to agricultural intensification