P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5.

Invasion of erythrocytes by Plasmodium falciparum merozoites is necessary for malaria pathogenesis and is therefore a primary target for vaccine development. RH5 is a leading subunit vaccine candidate because anti-RH5 antibodies inhibit parasite growth and the interaction with its erythrocyte receptor basigin is essential for invasion. RH5 is secreted, complexes with other parasite proteins including CyRPA and RIPR, and contains a conserved N-terminal region (RH5Nt) of unknown function that is cleaved from the native protein. Here, we identify P113 as a merozoite surface protein that directly interacts with RH5Nt. Using recombinant proteins and a sensitive protein interaction assay, we establish the binding interdependencies of all the other known RH5 complex components and conclude that the RH5Nt-P113 interaction provides a releasable mechanism for anchoring RH5 to the merozoite surface. We exploit these findings to design a chemically synthesized peptide corresponding to RH5Nt, which could contribute to a cost-effective malaria vaccine

Innovation and ownership variety

The role of ownership heterogeneity in influencing the extent and nature of innovation has been neglected but is an important omission as ownership differences can influence the goals, time horizons, and governance mechanisms relating to innovation. In this article I develop a novel framework that explores the potential impact and future research avenues in firms with a variety of ownership forms based on whether the organizational form in which innovation takes place is either a new venture or an existing business, and whether ownership involves new independent owners or existing independent owners of the organization. With respect to organizational form, new ventures are effectively locked into innovation by definition, while existing businesses may find a balance between investing in innovation and exploiting previous innovations, and engaging in more incremental innovation. Existing independent owners may be expected to take a more sustained view of innovation over time while new owners may be time delimited in their innovation. On the basis of this framework I analyze the following ownership types: academic spin-offs, private equity backed management buyouts, family firms and firms owned by habitual entrepreneurs. I identify the need for research to explore other ownership forms and the interaction between ownership types and different contexts