An Economic Analysis of Peer-Disclosure in Online Social Communities

We study a novel privacy concern, viz. peer disclosure of sensitive personal information in online social communities. We model peer disclosure as imposing a negative externality on other people. Our model encompasses the benefits from posting information, positive externalities such as recognition and entertainment benefits due to others' sharing of information, and heterogeneous privacy preferences. We find that regulation of peer disclosure is necessary. We consider two candidate regulations -- nudging and quota. Nudging reduces user participation and privacy harm and sometimes improve social welfare. By contrast, imposing a quota often improves user participation, privacy protection and social welfare. Adding a nudge on top of a quota does not bring additional benefits. We show that any regulation that uniformly controls the disclosure of sensitive and nonsensitive information will not serve the triple objectives of reducing privacy harm, increasing social welfare, and increasing information contribution. We derive a necessary condition for solutions that can fulfill these three objectives. We also compare the incentives of the platform owner and social planner and draw related managerial and policy implications

A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 A resolution.

Bacteriophage BPP-1 infects and kills Bordetella species that cause whooping cough. Its diversity-generating retroelement (DGR) provides a naturally occurring phage-display system, but engineering efforts are hampered without atomic structures. Here, we report a cryo electron microscopy structure of the BPP-1 head at 3.5 Å resolution. Our atomic model shows two of the three protein folds representing major viral lineages: jellyroll for its cement protein (CP) and HK97-like ('Johnson') for its major capsid protein (MCP). Strikingly, the fold topology of MCP is permuted non-circularly from the Johnson fold topology previously seen in viral and cellular proteins. We illustrate that the new topology is likely the only feasible alternative of the old topology. β-sheet augmentation and electrostatic interactions contribute to the formation of non-covalent chainmail in BPP-1, unlike covalent inter-protein linkages of the HK97 chainmail. Despite these complex interactions, the termini of both CP and MCP are ideally positioned for DGR-based phage-display engineering. DOI: http://dx.doi.org/10.7554/eLife.01299.001

Effects of supplementing lactic acid bacteria on fecal microbiota, total cholesterol, triglycerides and bile acids in rats.

Background: Probiotics (LAB) are normal components of the intestinal micro-flora in both humans and animals and its ingestion in decreasing the risk of atherosclerosis. In addition, the potential health effects of LAB were investigated by monitoring changes in intestinal micro-flora and lipid metabolism in a rat model.Materials and Methods: Rats were randomly assigned into four treatments and fecal samples were obtained on days 1, 3, 5, 9 and 14，to evaluate fecal micro biota, total cholesterol (TC), triglycerides (TG) and bile acids in rats (TBA).Results: The results indicated that Lactobacillus plantarum strain L.p X3-2B increased fecal lactic acid bacteria(LAB) and Bifidobacterium while resisting the growth of harmful bacteria. Viable counts of LAB and Bifidobacterium reached 8 log cfu/mL after feeding for 14 days. Fecal pH in the control group was high in comparison with the treatments at all times. Treatment increased the excretion of triglycerides (TG), total cholesterol (TC) and total bile acid (TBA). The results indicate that LAB and Bifidobacterium induce a positive correlation with fecal TC, TG and TBA and a negative correlation with fecal Enterobacteriaceae, Enterococcus and Escherichia coli.Conclusion: Lactic acid bacteria screened from Inner Mongolia native meat sausages in China had cholesterol-lowering effect.Keywords: Lactic acid bacteria, fecal micro biota, TC, TG, TB

Four Levels of Hierarchical Organization, Including Noncovalent Chainmail, Brace the Mature Tumor Herpesvirus Capsid against Pressurization

SummaryLike many double-stranded DNA viruses, tumor gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus withstand high internal pressure. Bacteriophage HK97 uses covalent chainmail for this purpose, but how this is achieved noncovalently in the much larger gammaherpesvirus capsid is unknown. Our cryoelectron microscopy structure of a gammaherpesvirus capsid reveals a hierarchy of four levels of organization: (1) Within a hexon capsomer, each monomer of the major capsid protein (MCP), 1,378 amino acids and six domains, interacts with its neighboring MCPs at four sites. (2) Neighboring capsomers are linked in pairs by MCP dimerization domains and in groups of three by heterotrimeric triplex proteins. (3) Small (∼280 amino acids) HK97-like domains in MCP monomers alternate with triplex heterotrimers to form a belt that encircles each capsomer. (4) One hundred sixty-two belts concatenate to form noncovalent chainmail. The triplex heterotrimer orchestrates all four levels and likely drives maturation to an angular capsid that can withstand pressurization

The radio counter-jet of the QSO 3C~48

We present multi--frequency radio observational results of the quasar 3C~48. The observations were carried out with the Very Large Array (VLA) at five frequencies of 0.33, 1.5, 4.8, 8.4, and 22.5 GHz, and with the Multi--Element Radio Linked Interferometer Network (MERLIN) at the two frequencies of 1.6 and 5 GHz. The source shows a one--sided jet to the north within 1\arcsec, which then extends to the northeast and becomes diffuse. Two bright components (N2 and N3), containing most of the flux density are present in the northern jet. The spectral index of the two components is $\alpha_{N2}\sim-0.99\pm0.12$ and $\alpha_{N3}\sim-0.84\pm0.23$ ($S\propto\nu^{\alpha}$). Our images show the presence of an extended structure surrounding component N2, suggestive of strong interaction between the jet and the interstellar medium (ISM) of the host galaxy. A steep--spectrum component, labelled as S, located 0.25 ardsec southwest to the flat--spectrum component which could be the core of 3C 48, is detected at a significance of $>15\sigma$. Both the location and the steepness of the spectrum of component S suggest the presence of a counter--jet in 3C 48.Comment: 7 pages, 6 figures, accepted by A&

The Tumor-Log Odds of Positive Lymph Nodes-Metastasis Staging System, a Promising New Staging System for Gastric Cancer after D2 Resection in China

BACKGROUND: In this study, we established a hypothetical tumor-lodds-metastasis (TLM) and tumor-ratio-metastasis (TRM) staging system. Moreover, we compared them with the 7(th) edition of American Joint Committee on Cancer tumor-nodes-metastasis (AJCC TNM) staging system in gastric cancer patients after D2 resection. METHODS: A total of 1000 gastric carcinoma patients receiving treatment in our center were selected for the analysis. Finally, 730 patients who received D2 resection were retrospectively studied. Patients were staged using the TLM, TRM and the 7(th) edition AJCC TNM system. Survival analysis was performed with a Cox regression model. We used two parameters to compare the TNM, TRM and TLM staging system, the -2log likelihood and the hazard ratio. RESULTS: The cut points of lymph node ratio (LNR) were set as 0, 0-0.3, 0.3-0.6, 0.6-1.0. And for the log odds of positive lymph nodes (LODDS), the cut points were established as≤-0.5, -0.5-0, 0-0.5, >0.5. There were significant differences in survival among patients in different LODDS classifications for each pN or LNR groups. When stratified by the LODDS classifications, the prognosis was highly homologous between those in the according pN or LNR classifications. Multivariate analysis showed that TLM staging system was better than the TRM or TNM system for the prognostic evaluation. CONCLUSIONS: The TLM system was superior to the TRM or TNM system for prognostic assessment of gastric adenocarcinoma patients after D2 resection