99 research outputs found
Wide-field common-path incoherent correlation microscopy with a perfect overlapping of interfering beams
Incoherent correlation microscopy is recently discovered technique for digital imaging of three-dimensional objects in a quasimonochromatic spatially incoherent light. Its operation is based on wavefront division carried out by a spatial light modulator and capturing correlation recordings of the observed scene. To achieve image reconstruction, at least a partial overlapping of the signal and reference waves created by the spatial light modulator is necessary. In the known experimental configurations, the overlapping of interfering beams is strongly reduced in off-axis areas of the object and the image can be reconstructed only in a very small portion of the field of view provided by the used microscope objective lens. Here, we propose and successfully demonstrate modified experimental system working with two-component relay optics inserted between the microscope objective and the spatial light modulator and providing full overlapping of correlated beams in all areas of the field of view of the objective lens. The benefits and applicability of the proposed system design are clearly demonstrated on the imaging of the USAF resolution targets
Rotating vortex imaging implemented by a quantized spiral phase modulation
We demonstrate both theoretically and experimentally that a spiral mask with a finite number of discrete phase levels allows a defocusing induced rotation of the point spread function in the vortex imaging. Two experimental configurations based on a spiral phase modulation of light and a spiral filtering of the spatial spectrum are studied in a unified theoretical treatment. The rotating point spread functions are analyzed in detail for imaging realized by the vortex lens and the 4-f system used in the spiral phase contrast microscopy. The theoretical results are verified by experiments using a spatial light modulator. The method is applicable to a precise focusing and optical imaging allowing depth estimation from diffracted rotation. Apart from implementation simplicity, the main advantages of the method are high energy efficiency, a possibility to operate with either complex amplitude or spatial spectrum of light and variability allowing a simple control of number of lobes of the point spread function
Quantum Mechanical Properties of Bessel Beams
Bessel beams are studied within the general framework of quantum optics. The
two modes of the electromagnetic field are quantized and the basic dynamical
operators are identified. The algebra of these operators is analyzed in detail;
it is shown that the operators that are usually associated to linear momentum,
orbital angular momentum and spin do not satisfy the algebra of the translation
and rotation group. In particular, what seems to be the spin is more similar to
the helicity. Some physical consequences of these results are examined.Comment: 17 pages, no figures. New versio
Rotational Effects of Twisted Light on Atoms Beyond the Paraxial Approximation
The transition probability for the emission of a Bessel photon by an atomic
system is calculated within first order perturbation theory. We derive a closed
expression for the electromagnetic potentials beyond the paraxial approximation
that permits a systematic multipole approximation . The matrix elements between
center of mass and internal states are evaluated for some specially relevant
cases. This permits to clarify the feasibility of observing the rotational
effects of twisted light on atoms predicted by the calculations. It is shown
that the probability that the internal state of an atom acquires orbital
angular momentum from light is, in general, maximum for an atom located at the
axis of a Bessel mode. For a Gaussian packet, the relevant parameter is the
ratio of the spread of the atomic center of mass wave packet to the transversal
wavelength of the photon.Comment: 10 pages, no figure
A relativistic study of Bessel beams
We present a fully relativistic analysis of Bessel beams revealing some
noteworthy features that are not explicit in the standard description. It is
shown that there is a reference frame in which the field takes a particularly
simple form, the wave appearing to rotate in circles. The concepts of
polarization and angular momentum for Bessel beams is also reanalyzed.Comment: 11 pages, 2 fig
Experimental test of uncertainty relations for quantum mechanics on a circle
We rederive uncertainty relations for the angular position and momentum of a
particle on a circle by employing the exponential of the angle instead of the
angle itself, which leads to circular variance as a natural measure of
resolution. Intelligent states minimizing the uncertainty product under the
constraint of a given uncertainty in angle or in angular momentum turn out to
be given by Mathieu wave functions. We also discuss a number of physically
feasible approximations to these optimal states. The theory is applied to the
orbital angular momentum of a beam of photons and verified in an experiment
that employs computer-controlled spatial light modulators both at the state
preparation and analyzing stages.Comment: 12 pages, 9 figures. Submitted for publicatio
Do serum biomarkers really measure breast cancer?
Background
Because screening mammography for breast cancer is less effective for premenopausal women, we investigated the feasibility of a diagnostic blood test using serum proteins.
Methods
This study used a set of 98 serum proteins and chose diagnostically relevant subsets via various feature-selection techniques. Because of significant noise in the data set, we applied iterated Bayesian model averaging to account for model selection uncertainty and to improve generalization performance. We assessed generalization performance using leave-one-out cross-validation (LOOCV) and receiver operating characteristic (ROC) curve analysis.
Results
The classifiers were able to distinguish normal tissue from breast cancer with a classification performance of AUC = 0.82 ± 0.04 with the proteins MIF, MMP-9, and MPO. The classifiers distinguished normal tissue from benign lesions similarly at AUC = 0.80 ± 0.05. However, the serum proteins of benign and malignant lesions were indistinguishable (AUC = 0.55 ± 0.06). The classification tasks of normal vs. cancer and normal vs. benign selected the same top feature: MIF, which suggests that the biomarkers indicated inflammatory response rather than cancer.
Conclusion
Overall, the selected serum proteins showed moderate ability for detecting lesions. However, they are probably more indicative of secondary effects such as inflammation rather than specific for malignancy.United States. Dept. of Defense. Breast Cancer Research Program (Grant No. W81XWH-05-1-0292)National Institutes of Health (U.S.) (R01 CA-112437-01)National Institutes of Health (U.S.) (NIH CA 84955
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Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF
M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe
Reconciling the stratigraphy and depositional history of the Lycian orogen-top basins, SW Anatolia
Terrestrial fossil records from the SWAnatolian basins are crucial both for regional correlations and palaeoenvironmental reconstructions.
By reassessing biostratigraphic constraints and incorporating new fossil data, we calibrated and reconstructed the late Neogene
andQuaternary palaeoenvironments within a regional palaeogeographical framework. The culmination of the Taurides inSWAnatolia
was followed by a regional crustal extension from the late Tortonian onwards that created a broad array of NE-trending orogen-top
basins with synchronic associations of alluvial fan, fluvial and lacustrine deposits. The terrestrial basins are superimposed on the upper
Burdigalian marine units with a c. 7 myr of hiatus that corresponds to a shift from regional shortening to extension. The initial infill of
these basins is documented by a transition from marginal alluvial fans and axial fluvial systems into central shallow-perennial lakes
coinciding with a climatic shift from warm/humid to arid conditions. The basal alluvial fan deposits abound in fossil macro-mammals
of an early Turolian (MN11–12; late Tortonian) age. The Pliocene epoch in the region was punctuated by subhumid/humid conditions
resulting in a rise of local base levels and expansion of lakes as evidenced by marsh-swamp deposits containing diverse fossilmammal
assemblages indicating late Ruscinian (lateMN15; late Zanclean) ageWe are grateful for the support of the international
bilateral project between The Scientific and Technological Research
Council of Turkey (TUBITAK) and The Russian Scientific Foundation
(RFBR) with grant a number of 111Y192. M.C.A. is grateful to the
Turkish Academy of Sciences (TUBA) for a GEBIP (Young Scientist
Award) grant. T.K. and S.M. are grateful to the Ege University
Scientific Research Center for the TTM/002/2016 and TTM/001/2016
projects. M.C.A., H.A., S.M. and M.B. have obtained Martin and
Temmick Fellowships at Naturalis Biodiversity Center (Leiden). F.A.D.
is supported by a Mehmet Akif Ersoy University Scientific Research
Grant. T.A.N. is supported by an Alexander-von-Humboldt
Scholarship. L.H.O. received support from TUBITAK under the 2221
program for visiting scientists
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