No Card Cat—No Problem! : WLN’s Lasercat Provides Another Opportunity for Cooperation

This article discusses the implementation of WLN’s Laser-Cat CD-ROM catalog in a medium-sized academic li brary. It describes the creation of a LaserCat/Information desk in the library lobby and the use of technical services librarians and paraprofessional staff from technical services and elsewhere in the library to staff the desk. In large libraries, public and technical services functions have generally been quite distinct. In small libraries, on the other hand, every librarian and staff member has had to be a generalist, and there may not be the possibility of maintaining a strict division between the traditional functions, even if that were thought to be desirable. In a medium-sized library, predictably, the situation may be somewhere in between. More communication and cooperation may be achieved with somewhat less effort than is required in a large library, but the organizational chart of a medium-sized library is likely to be more similar to that of a large library than a small one. The idea of breaking down the barriers between the traditional technical and public service functions in libraries is extensively discussed in library literature, at professional meetings, and elsewhere. Automation is one reason why this idea is discussed so frequently. The catalog no longer resides in one place, and therefore the people who maintain the catalog may also be dispersed. Catalogs need no longer contain only conventional bibliographic records for conventional library materials, which may mean more participation in database building by public services personnel. Technical services staff may be faced with the prospect of sitting in front of a computer screen eight hours a day. Staffing a reference or information desk can provide needed variety as well as being an other good use for the knowledge developed in technical services activities

No Card Cat—No Problem! : WLN’s Lasercat Provides Another Opportunity for Cooperation

This article discusses the implementation of WLN’s Laser-Cat CD-ROM catalog in a medium-sized academic li brary. It describes the creation of a LaserCat/Information desk in the library lobby and the use of technical services librarians and paraprofessional staff from technical services and elsewhere in the library to staff the desk. In large libraries, public and technical services functions have generally been quite distinct. In small libraries, on the other hand, every librarian and staff member has had to be a generalist, and there may not be the possibility of maintaining a strict division between the traditional functions, even if that were thought to be desirable. In a medium-sized library, predictably, the situation may be somewhere in between. More communication and cooperation may be achieved with somewhat less effort than is required in a large library, but the organizational chart of a medium-sized library is likely to be more similar to that of a large library than a small one. The idea of breaking down the barriers between the traditional technical and public service functions in libraries is extensively discussed in library literature, at professional meetings, and elsewhere. Automation is one reason why this idea is discussed so frequently. The catalog no longer resides in one place, and therefore the people who maintain the catalog may also be dispersed. Catalogs need no longer contain only conventional bibliographic records for conventional library materials, which may mean more participation in database building by public services personnel. Technical services staff may be faced with the prospect of sitting in front of a computer screen eight hours a day. Staffing a reference or information desk can provide needed variety as well as being an other good use for the knowledge developed in technical services activities

MPEC 2020-A99: 2020 AV2

[no abstract

Bayesian Computing with INLA: A Review

The key operation in Bayesian inference is to compute high-dimensional integrals. An old approximate technique is the Laplace method or approximation, which dates back to Pierre-Simon Laplace (1774). This simple idea approximates the integrand with a second-order Taylor expansion around the mode and computes the integral analytically. By developing a nested version of this classical idea, combined with modern numerical techniques for sparse matrices, we obtain the approach of integrated nested Laplace approximations (INLA) to do approximate Bayesian inference for latent Gaussian models (LGMs). LGMs represent an important model abstraction for Bayesian inference and include a large proportion of the statistical models used today. In this review, we discuss the reasons for the success of the INLA approach, the R-INLA package, why it is so accurate, why the approximations are very quick to compute, and why LGMs make such a useful concept for Bayesian computing

Palomar discovery and initial characterization of naked-eye long period comet C/2022 E3 (ZTF)

Long-period comets are planetesimal remnants constraining the environment and volatiles of the protoplanetary disc. We report the discovery of hyperbolic long-period comet C/2022 E3 (ZTF), which has a perihelion $\sim$1.11 au, an eccentricity $\gtrsim$1 and an inclination $\sim$109$^{\circ}$, from images taken with the Palomar 48-inch telescope during morning twilight on 2022 Mar 2. Additionally, we report the characterization of C/2022 E3 (ZTF) from observations taken with the Palomar 200-inch, the Palomar 60-inch, and the NASA Infrared Telescope Facility in early 2023 February to 2023 March when the comet passed within $\sim$0.28 au of the Earth and reached a visible magnitude of $\sim$5. We measure g-r = 0.70$\pm$0.01, r-i = 0.20$\pm$0.01, i-z = 0.06$\pm$0.01, z-J = 0.90$\pm$0.01, J-H = 0.38$\pm$0.01 and H-K = 0.15$\pm$0.01 colours for the comet from observations. We measure the A(0$^\circ$)f$\rho$ (0.8~$\mu$m) in a 6500~km radius from the nucleus of 1483$\pm$40~cm, and CN, C$_3$, and C$_2$ production of 5.43$\pm0.11\times$10$^{25}$~mol/s, 2.01$\pm0.04\times$10$^{24}$, and 3.08$\pm0.5\times$10$^{25}$~mol/s, similar to other long period comets. We additionally observe the appearance of jet-like structures at a scale of $\sim$4,000 km in wide-field g-band images, which may be caused by the presence of CN gas in the near-nucleus coma.Comment: Accepted for publication in MNRAS:L, 9 pages, 6 figures, 2 table

(Against a) Theory of Audience Engagement with News

Audience engagement has become a key concept in contemporary discussions on how news companies relate to the public and create sustainable business models. These discussions are irrevocably tied to practices of monitoring, harvesting and analyzing audience behaviours with metrics, which is increasingly becoming the new currency of the media economy. This article argues this growing tendency to equate engagement to behavioural analytics, and study it primarily through quantifiable data, is limiting. In response, we develop a heuristic theory of audience engagement with news comprising four dimensions—the technical-behavioural, emotional, normative and spatiotemporal—and explicate these in terms of different relations of engagement between human-to-self, human-to-human, human-to-content, human-to-machine, and machine-to-machine. Paradoxically, this model comprises a specific theory of audience engagement while simultaneously making visible that constructing a theory of audience engagement is an impossible task. The article concludes by articulating methodological premises, which future empirical research on audience engagement should consider

Identification of novel subgroup a variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus

<b>BACKGROUND:</b> The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A, through alterations in the amino acid sequence of the receptor binding domain (RBD) of the envelope glycoprotein that result in a shift in the receptor usage and the cell tropism of the virus. The factors that influence the transition from subgroup A to subgroup C remain unclear, one possibility is that a selective pressure in the host drives the acquisition of mutations in the RBD, creating A/C intermediates with enhanced abilities to interact with the FeLV-C receptor, FLVCR. In order to understand further the emergence of FeLV-C in the infected cat, we examined primary isolates of FeLV-C for evidence of FeLV-A variants that bore mutations consistent with a gradual evolution from FeLV-A to FeLV-C.<p></p> <b>RESULTS:</b> Within each isolate of FeLV-C, we identified variants that were ostensibly subgroup A by nucleic acid sequence comparisons, but which bore mutations in the RBD. One such mutation, N91D, was present in multiple isolates and when engineered into a molecular clone of the prototypic FeLV-A (Glasgow-1), enhanced replication was noted in feline cells. Expression of the N91D Env on murine leukaemia virus (MLV) pseudotypes enhanced viral entry mediated by the FeLV-A receptor THTR1 while soluble FeLV-A Env bearing the N91D mutation bound more efficiently to mouse or guinea pig cells bearing the FeLV-A and -C receptors. Long-term in vitro culture of variants bearing the N91D substitution in the presence of anti-FeLV gp70 antibodies did not result in the emergence of FeLV-C variants, suggesting that additional selective pressures in the infected cat may drive the subsequent evolution from subgroup A to subgroup C.<p></p> <b>CONCLUSIONS:</b> Our data support a model in which variants of FeLV-A, bearing subtle differences in the RBD of Env, may be predisposed towards enhanced replication in vivo and subsequent conversion to FeLV-C. The selection pressures in vivo that drive the emergence of FeLV-C in a proportion of infected cats remain to be established

Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

<p>Abstract</p> <p>Background</p> <p>Niemann-Pick disease type A and B is caused by a deficiency of acid sphingomyelinase due to mutations in the sphingomyelin phosphodiesterase-1 (<it>SMPD1</it>) gene. In Niemann-Pick patients, <it>SMPD1 </it>gene defects are reported to be associated with a severe reduction in plasma high-density lipoprotein (HDL) cholesterol.</p> <p>Methods</p> <p>Two common coding polymorphisms in the <it>SMPD1 </it>gene, the G1522A (G508R) and a hexanucleotide repeat sequence within the signal peptide region, were investigated in 118 unrelated subjects of French Canadian descent with low plasma levels of HDL-cholesterol (< 5^thpercentile for age and gender-matched subjects). Control subjects (n = 230) had an HDL-cholesterol level > the 25^thpercentile.</p> <p>Results</p> <p>For G1522A the frequency of the G and A alleles were 75.2% and 24.8% respectively in controls, compared to 78.6% and 21.4% in subjects with low HDL-cholesterol (<it>p </it>= 0.317). The frequency of 6 and 7 hexanucleotide repeats was 46.2% and 46.6% respectively in controls, compared to 45.6% and 49.1% in subjects with low HDL-cholesterol (<it>p </it>= 0.619). Ten different haplotypes were observed in cases and controls. Overall haplotype frequencies in cases and controls were not significantly different.</p> <p>Conclusion</p> <p>These results suggest that the two common coding variants at the <it>SMPD1 </it>gene locus are not associated with low HDL-cholesterol levels in the French Canadian population.</p

Anthromes dispaying evidence of weekly cycles in active fire data cover 70% of the global land surface

Across the globe, human activities have been gaining importance relatively to climate and ecology as the main controls on fire regimes and consequently human activity became an important driver of the frequency, extent and intensity of vegetation burning worldwide. Our objective in the present study is to look for weekly cycles in vegetation fire activity at global scale as evidence of human agency, relying on the original MODIS active fire detections at 1 km spatial resolution (MCD14ML) and using novel statistical methodologies to detect significant periodicities in time series data. We tested the hypotheses that global fire activity displays weekly cycles and that the weekday with the fewest fires is Sunday. We also assessed the effect of land use and land cover on weekly fire cycle significance by testing those hypotheses separately for the Villages, Settlements, Croplands, Rangelands, Seminatural, and Wildlands anthromes. Based on a preliminary data analysis of the daily global active fire counts periodogram, we developed an harmonic regression model for the mean function of daily fire activity and assumed a linear model for the de-seasonalized time series. For inference purposes, we used a Bayesian methodology and constructed a simultaneous 95% credible band for the mean function. The hypothesis of a Sunday weekly minimum was directly investigated by computing the probabilities that the mean functions of every weekday (Monday to Saturday) are inside the credible band corresponding to mean Sunday fire activity. Since these probabilities are small, there is statistical evidence of significantly fewer fires on Sunday than on the other days of the week. Cropland, rangeland, and seminatural anthromes, which cover 70% of the global land area and account for 94% of the active fires analysed, display weekly cycles in fire activity. Due to lower land management intensity and less strict control over fire size and duration, weekly cycles in Rangelands and Seminatural anthromes, which jointly account for 53.46% of all fires, although statistically significant are weaker than those detected in Croplandsinfo:eu-repo/semantics/publishedVersio