1,229 research outputs found
Combined Endocyclophotocoagulation and Phacoemulsification in Patients with Glaucoma of African Descent
The aim of this study was to evaluate the outcomes of combined endocyclophotocoagulation (ECP) and phacoemulsification regarding vision, refraction, intraocular pressure (IOP), medication dependence, and complications in patients of African descent. A retrospective chart review was performed including all cases of ECP combined with phacoemulsification from October 2015 to March 2017. Exclusion criteria consisted of patients who were not of African descent and patients with <1 month follow-up. IOP was the primary outcome. Thirty-two eyes of 29 patients were included in the study. Mean ± standard deviation (SD) of IOP decreased from 17.30 ± 6.30 mmHg preoperatively to 15.88 ± 4.23 mmHg at the last postoperative visit (P = 0.301). In 2 of eight patients who did not demonstrate a difference in pre- and postoperative IOP changes, all IOP lowering medications were stopped. The mean ± SD of follow-up was 5.05 ± 4.08 months with a range of 1 to 18 months. The mean ± SD number of medications used for each patient for IOP control decreased from 2.59 ± 1.01 preoperatively to 1.97 ±1.38 (P = 0.045). Average visual acuity improved from 20/50 preoperatively to 20/25 (P = 0.002). Postoperative complication rate was low. ECP combined with phacoemulsification was effective to decrease IOP lowering medication dependence in patients of African descent. We found that combined ECP and phacoemulsification can lead to a significantly decreased dependence on IOP lowering drops, with some patients demonstrating complete independence from drops following surgery. Although there was not a significant decrease in IOP postoperatively when analyzed collectively, larger studies might to find such an association. Combined ECP and phacoemulsification has been shown to be a safe combination in patients with refractive glaucoma and may be considered if a patient desire less dependence on IOP lowering drops once other first-line methods have failed, or as a bridge between conservative and more definitive surgical treatment. Epub: October 1, 201
Mechanisms of Lymphatic Regeneration after Tissue Transfer
Lymphedema is the chronic swelling of an extremity that occurs commonly after lymph node resection for cancer treatment. Recent studies have demonstrated that transfer of healthy tissues can be used as a means of bypassing damaged lymphatics and ameliorating lymphedema. The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue transfer.Nude mice (recipients) underwent 2-mm tail skin excisions that were either left open or repaired with full-thickness skin grafts harvested from donor transgenic mice that expressed green fluorescent protein in all tissues or from LYVE-1 knockout mice. Lymphatic regeneration, expression of VEGF-C, macrophage infiltration, and potential for skin grafting to bypass damaged lymphatics were assessed.Skin grafts healed rapidly and restored lymphatic flow. Lymphatic regeneration occurred beginning at the peripheral edges of the graft, primarily from ingrowth of new lymphatic vessels originating from the recipient mouse. In addition, donor lymphatic vessels appeared to spontaneously re-anastomose with recipient vessels. Patterns of VEGF-C expression and macrophage infiltration were temporally and spatially associated with lymphatic regeneration. When compared to mice treated with excision only, there was a 4-fold decrease in tail volumes, 2.5-fold increase in lymphatic transport by lymphoscintigraphy, 40% decrease in dermal thickness, and 54% decrease in scar index in skin-grafted animals, indicating that tissue transfer could bypass damaged lymphatics and promote rapid lymphatic regeneration.Our studies suggest that lymphatic regeneration after tissue transfer occurs by ingrowth of lymphatic vessels and spontaneous re-connection of existing lymphatics. This process is temporally and spatially associated with VEGF-C expression and macrophage infiltration. Finally, tissue transfer can be used to bypass damaged lymphatics and promote rapid lymphatic regeneration
Nuclear classical dynamics of H in intense laser field
In the first part of this paper, the different distinguishable pathways and
regions of the single and sequential double ionization are determined and
discussed. It is shown that there are two distinguishable pathways for the
single ionization and four distinct pathways for the sequential double
ionization. It is also shown that there are two and three different regions of
space which are related to the single and double ionization respectively. In
the second part of the paper, the time dependent Schr\"{o}dinger and Newton
equations are solved simultaneously for the electrons and the nuclei of H
respectively. The electrons and nuclei dynamics are separated on the base of
the adiabatic approximation. The soft-core potential is used to model the
electrostatic interaction between the electrons and the nuclei. A variety of
wavelengths (390 nm, 532 nm and 780 nm) and intensities (
and ) of the ultrashort intense laser
pulses with a sinus second order envelope function are used. The behaviour of
the time dependent classical nuclear dynamics in the absence and present of the
laser field are investigated and compared. In the absence of the laser field,
there are three distinct sections for the nuclear dynamics on the electronic
ground state energy curve. The bond hardening phenomenon does not appear in
this classical nuclear dynamics simulation.Comment: 16 pages, 7 figure
Androgen-induced cerebral venous sinus thrombosis in a young body builder: case report
BACKGROUND: Cerebral venous sinus thrombosis is an infrequent disease with a variety of causes. Pregnancy, puerperium, contraceptive pills and intracranial infections are the most common causes. The patient may present with headache, focal neurological deficits and seizures. The clinical outcome is highly variable and treatment with heparin is advised. CASE PRESENTATION: The patient is a 22 year old male who presented with headache, repeated vomiting and papilledema. He was a bodybuilder doing exercise since 5 years ago, who had used nandrolone decaonoate 25 milligrams intramuscularly during the previous 5 months. Brain MRI and MRV showed superior sagital and transverse sinus thrombosis and extensive investigations did not reveal any known cause. CONCLUSIONS: We suggested that androgen was the predisposing factor in our patient. Androgens may increase coagulation factors or platelet activity and cause arterial or venous thrombosis. As athletes may hide using androgens it should be considered as a predisposing factor for thrombotic events in such patients
Science with the space-based interferometer LISA. V Extreme mass-ratio inspirals
The space-based Laser Interferometer Space Antenna (LISA) will be able to
observe the gravitational-wave signals from systems comprised of a massive
black hole and a stellar-mass compact object. These systems are known as
extreme-mass-ratio inspirals (EMRIs) and are expected to complete - cycles in band, thus allowing exquisite measurements of their
parameters. In this work, we attempt to quantify the astrophysical
uncertainties affecting the predictions for the number of EMRIs detectable by
LISA, and find that competing astrophysical assumptions produce a variance of
about three orders of magnitude in the expected intrinsic EMRI rate. However,
we find that irrespective of the astrophysical model, at least a few EMRIs per
year should be detectable by the LISA mission, with up to a few thousands per
year under the most optimistic astrophysical assumptions. We also investigate
the precision with which LISA will be able to extract the parameters of these
sources. We find that typical fractional statistical errors with which the
intrinsic parameters (redshifted masses, massive black hole spin and orbital
eccentricity) can be recovered are -. Luminosity
distance (which is required to infer true masses) is inferred to about
precision and sky position is localized to a few square degrees, while tests of
the multipolar structure of the Kerr metric can be performed to percent-level
precision or better.Comment: 13 figures, 22 pages; updated to match published versio
Pulsar Timing and its Application for Navigation and Gravitational Wave Detection
Pulsars are natural cosmic clocks. On long timescales they rival the
precision of terrestrial atomic clocks. Using a technique called pulsar timing,
the exact measurement of pulse arrival times allows a number of applications,
ranging from testing theories of gravity to detecting gravitational waves. Also
an external reference system suitable for autonomous space navigation can be
defined by pulsars, using them as natural navigation beacons, not unlike the
use of GPS satellites for navigation on Earth. By comparing pulse arrival times
measured on-board a spacecraft with predicted pulse arrivals at a reference
location (e.g. the solar system barycenter), the spacecraft position can be
determined autonomously and with high accuracy everywhere in the solar system
and beyond. We describe the unique properties of pulsars that suggest that such
a navigation system will certainly have its application in future astronautics.
We also describe the on-going experiments to use the clock-like nature of
pulsars to "construct" a galactic-sized gravitational wave detector for
low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the
current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks,
Springer Space Science Review
The impact of realistic models of mass segregation on the event rate of extreme-mass ratio inspirals and cusp re-growth
One of the most interesting sources of gravitational waves (GWs) for LISA is
the inspiral of compact objects on to a massive black hole (MBH), commonly
referred to as an "extreme-mass ratio inspiral" (EMRI). The small object,
typically a stellar black hole (bh), emits significant amounts of GW along each
orbit in the detector bandwidth. The slowly, adiabatic inspiral of these
sources will allow us to map space-time around MBHs in detail, as well as to
test our current conception of gravitation in the strong regime. The event rate
of this kind of source has been addressed many times in the literature and the
numbers reported fluctuate by orders of magnitude. On the other hand, recent
observations of the Galactic center revealed a dearth of giant stars inside the
inner parsec relative to the numbers theoretically expected for a fully relaxed
stellar cusp. The possibility of unrelaxed nuclei (or, equivalently, with no or
only a very shallow cusp) adds substantial uncertainty to the estimates. Having
this timely question in mind, we run a significant number of direct-summation
body simulations with up to half a million particles to calibrate a much
faster orbit-averaged Fokker-Planck code. We then investigate the regime of
strong mass segregation (SMS) for models with two different stellar mass
components. We show that, under quite generic initial conditions, the time
required for the growth of a relaxed, mass segregated stellar cusp is shorter
than a Hubble time for MBHs with
(i.e. nuclei in the range of LISA). SMS has a significant impact boosting the
EMRI rates by a factor of for our fiducial models of Milky Way type
galactic nuclei.Comment: Accepted by CQG, minor changes, a bit expande
Gene Function Classification Using Bayesian Models with Hierarchy-Based Priors
We investigate the application of hierarchical classification schemes to the
annotation of gene function based on several characteristics of protein
sequences including phylogenic descriptors, sequence based attributes, and
predicted secondary structure. We discuss three Bayesian models and compare
their performance in terms of predictive accuracy. These models are the
ordinary multinomial logit (MNL) model, a hierarchical model based on a set of
nested MNL models, and a MNL model with a prior that introduces correlations
between the parameters for classes that are nearby in the hierarchy. We also
provide a new scheme for combining different sources of information. We use
these models to predict the functional class of Open Reading Frames (ORFs) from
the E. coli genome. The results from all three models show substantial
improvement over previous methods, which were based on the C5 algorithm. The
MNL model using a prior based on the hierarchy outperforms both the
non-hierarchical MNL model and the nested MNL model. In contrast to previous
attempts at combining these sources of information, our approach results in a
higher accuracy rate when compared to models that use each data source alone.
Together, these results show that gene function can be predicted with higher
accuracy than previously achieved, using Bayesian models that incorporate
suitable prior information
Advanced localization of massive black hole coalescences with LISA
The coalescence of massive black holes is one of the primary sources of
gravitational waves (GWs) for LISA. Measurements of the GWs can localize the
source on the sky to an ellipse with a major axis of a few tens of arcminutes
to a few degrees, depending on source redshift, and a minor axis which is 2--4
times smaller. The distance (and thus an approximate redshift) can be
determined to better than a per cent for the closest sources we consider,
although weak lensing degrades this performance. It will be of great interest
to search this three-dimensional `pixel' for an electromagnetic counterpart to
the GW event. The presence of a counterpart allows unique studies which combine
electromagnetic and GW information, especially if the counterpart is found
prior to final merger of the holes. To understand the feasibility of early
counterpart detection, we calculate the evolution of the GW pixel with time. We
find that the greatest improvement in pixel size occurs in the final day before
merger, when spin precession effects are maximal. The source can be localized
to within 10 square degrees as early as a month before merger at ; for
higher redshifts, this accuracy is only possible in the last few days.Comment: 11 pages, 4 figures, version published in Classical and Quantum
Gravity (special issue for proceedings of 7th International LISA Symposium
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