Early Toxicities After High Dose Rate Proton Therapy in Cancer Treatments

Background: The conventional dose rate of radiation therapy is 0.01-0.05 Gy per second. According to preclinical studies, an increased dose rate may offer similar anti-tumoral effect while dramatically improving normal tissue protection. This study aims at evaluating the early toxicities for patients irradiated with high dose rate pulsed proton therapy (PT). Materials and methods: A single institution retrospective chart review was performed for patients treated with high dose rate (10 Gy per second) pulsed proton therapy, from September 2016 to April 2020. This included both benign and malignant tumors with ≥3 months follow-up, evaluated for acute (≤2 months) and subacute (>2 months) toxicity after the completion of PT. Results: There were 127 patients identified, with a median follow up of 14.8 months (3-42.9 months). The median age was 55 years (1.6-89). The cohort most commonly consisted of benign disease (55.1%), cranial targets (95.1%), and were treated with surgery prior to PT (56.7%). There was a median total PT dose of 56 Gy (30-74 Gy), dose per fraction of 2 Gy (1-3 Gy), and CTV size of 47.6 ml (5.6-2,106.1 ml). Maximum acute grade ≥2 toxicity were observed in 49 (38.6%) patients, of which 8 (6.3%) experienced grade 3 toxicity. No acute grade 4 or 5 toxicity was observed. Maximum subacute grade 2, 3, and 4 toxicity were discovered in 25 (19.7%), 12 (9.4%), and 1 (0.8%) patient(s), respectively. Conclusion: In this cohort, utilizing high dose rate proton therapy (10 Gy per second) did not result in a major decrease in acute and subacute toxicity. Longer follow-up and comparative studies with conventional dose rate are required to evaluate whether this approach offers a toxicity benefit

Vestígios indígenas na cartografia do sertão da América portuguesa

During the first three centuries of colonization of Portuguese America, indigenous cartography helped the outlanders to decipher the space that they conventionally named sertão (backcountry). The colonizers in the Captaincy of São Paulo (expeditions, soldiers, settlers, bureaucrats, merchants, and adventurers) mapped out the hinterland with utmost care. However, because the territory was a colony, such agents reorganized that space and classified the ethnic groups into distinct, fixed and homogenous categories. As the Portuguese Crown moved ahead with its conquest, the indigenous groups were gradually wiped out from the maps and their territories expropriated.Nos três primeiros séculos da colonização da América portuguesa, a cartografia indígena auxiliou no processo de decodificação do espaço convencionalmente chamado "sertão" pelos adventícios. Agentes de colonização da capitania de São Paulo (bandeirantes, soldados, povoadores, burocratas, comerciantes e aventureiros) mapearam cuidadosamente os territórios interiores. A situação colonial, entretanto, impôs uma nova orientação do espaço, bem como classificou os grupos étnicos em categorias distintas, fixas e homogêneas. Nesse processo de conquista da Coroa portuguesa, os grupos indígenas foram gradativamente eclipsados dos mapas, e seus territórios, expropriados

Nicolas Marty, 2013, L’invention de l’eau embouteillée : Qualités, normes et marché de l’eau en bouteille en Europe XIXe-XXe siècles, Bruxelles

Lévi Yves. Nicolas Marty, 2013, L’invention de l’eau embouteillée : Qualités, normes et marché de l’eau en bouteille en Europe XIXe-XXe siècles, Bruxelles. In: Revue d’études en Agriculture et Environnement, Vol. 96, N°2, 2015. pp. 367-370

Mot à mot. Toxicologie/Toxicologie environnementale/Ecotoxicologie.

International audienc

Modélisation des flux horaires et journaliers de médicaments en entrée de station d'épuration à l'aval d'un bassin versant urbain et d'un hôpital

National audienc

Modélisation stochastique des flux horaires de médicaments depuis leurs ventes jusqu’à la station d’épuration

National audienc