Leser-Trélat sign: Does it really exist?

Leser-Trelat sign is a rare cutaneous disorder that appears by sudden emergence of seborrheic keratoses and increase in their numbers and size just in weeks or months. Its cooccurence with many kinds of malignancies, especially with adenocarcinoma and lymphoma, has been reported in literature. In this case report, a patient having Leser Trélat sign, without any detected malignancy in spite of a detailed examination and 18 months of follow-up, is presented. The current literature is being discussed whether Leser-Trélat is a paraneoplastic syndrome or not

Leser-Trélat sign: Does it really exist?

Leser-Trelat sign is a rare cutaneous disorder that appears by sudden emergence of seborrheic keratoses and increase in their numbers and size just in weeks or months. Its cooccurence with many kinds of malignancies, especially with adenocarcinoma and lymphoma, has been reported in literature. In this case report, a patient having Leser Trélat sign, without any detected malignancy in spite of a detailed examination and 18 months of follow-up, is presented. The current literature is being discussed whether Leser-Trélat is a paraneoplastic syndrome or not

Effectiveness and safety of topical emollients in the treatment of PUVA-induced pruritus

GUREL, Mehmet Salih/0000-0002-7031-6516WOS: 000328605800014PubMed: 24285457Background. In this study we tried to assess the efficacy of topical emollients in the treatment of patients with PUVA-induced pruritus. Material and Methods. 41 patients over 18 years of age, who received PUVA treatment in the phototherapy unit, were included in the study. Patients were randomly divided into two groups; Group I was administered with a 4% urea lotion and Group II was administered with liquid petrolatum. The follow-up period was minimum 4 weeks. During the first 2 weeks, patients were administered topical emollients and received PUVA treatment together. The next 2 weeks, they continued PUVA treatment without any medication. Results. When time-dependent changes in the visual analogue scale scores for pruritus of both groups were considered, both treatment methods were found to be remarkably successful (p < 0.0001). In addition, an insignificant group-time interaction was identified (p = 0.753). Conclusions. Topical emollients were found to be effective in the treatment of PUVA-induced pruritus. Both forms of medication can be successfully administered and increase the patient's compliance with medicatio

Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors

Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.Scientific Research and Support Unit of Firat University [TF.19.29]We thank the Scientific Research and Support Unit of Firat University for their financial support for the conduct of the study with the protocol number TF.19.29