The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.

The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38-/-, TAp63+/-, and Rbm38-/-;TAp63+/- mice were generated and monitored throughout their lifespan. While mice deficient in Rbm38 or TAp63 alone died mostly from spontaneous tumors, compound Rbm38-/-;TAp63+/- mice had an extended lifespan along with reduced tumor incidence. We also found that loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63+/- mice. Moreover, we found that Rbm38 deficiency extends the lifespan of tumor-free TAp63+/- mice along with reduced expression of senescence-associated biomarkers. Consistent with this, Rbm38-/-;TAp63+/- MEFs were resistant, whereas Rbm38-/- or TAp63+/- MEFs were prone, to cellular senescence. Importantly, we showed that the levels of inflammatory cytokines (IL17D and Tnfsf15) were significantly reduced by Rbm38 deficiency in senescence-resistant Rbm38-/-;TAp63+/- mouse livers and MEFs. Together, our data suggest that Rbm38 and p63 function as intergenic suppressors in aging and tumorigenesis and that the Rbm38-p63 loop may be explored for enhancing longevity and cancer management

A cyber-physical machine tools platform using OPC UA and MTConnect

Cyber-Physical Machine Tools (CPMT) represent a new generation of machine tools that are smarter, well connected, widely accessible, more adaptive and more autonomous. Development of CPMT requires standardized information modelling method and communication protocols for machine tools. This paper proposes a CPMT Platform based on OPC UA and MTConnect that enables standardized, interoperable and efficient data communication among machine tools and various types of software applications. First, a development method for OPC UA-based CPMT is proposed based on a generic OPC UA information model for CNC machine tools. Second, to address the issue of interoperability between OPC UA and MTConnect, an MTConnect to OPC UA interface is developed to transform MTConnect information model and its data to their OPC UA counterparts. An OPC UA-based CPMT prototype is developed and further integrated with a previously developed MTConnect-based CPMT to establish a common CPMT Platform. Third, different applications are developed to demonstrate the advantages of the proposed CPMT Platform, including an OPC UA Client, an advanced AR-assisted wearable Human-Machine Interface and a conceptual framework for CPMT powered cloud manufacturing environment. Experimental results have proven that the proposed CPMT Platform can significantly improve the overall production efficiency and effectiveness in the shop floor

High-Resolution Deep Image Matting

Image matting is a key technique for image and video editing and composition. Conventionally, deep learning approaches take the whole input image and an associated trimap to infer the alpha matte using convolutional neural networks. Such approaches set state-of-the-arts in image matting; however, they may fail in real-world matting applications due to hardware limitations, since real-world input images for matting are mostly of very high resolution. In this paper, we propose HDMatt, a first deep learning based image matting approach for high-resolution inputs. More concretely, HDMatt runs matting in a patch-based crop-and-stitch manner for high-resolution inputs with a novel module design to address the contextual dependency and consistency issues between different patches. Compared with vanilla patch-based inference which computes each patch independently, we explicitly model the cross-patch contextual dependency with a newly-proposed Cross-Patch Contextual module (CPC) guided by the given trimap. Extensive experiments demonstrate the effectiveness of the proposed method and its necessity for high-resolution inputs. Our HDMatt approach also sets new state-of-the-art performance on Adobe Image Matting and AlphaMatting benchmarks and produce impressive visual results on more real-world high-resolution images.Comment: AAAI 202

Learning Raw Image Denoising with Bayer Pattern Unification and Bayer Preserving Augmentation

In this paper, we present new data pre-processing and augmentation techniques for DNN-based raw image denoising. Compared with traditional RGB image denoising, performing this task on direct camera sensor readings presents new challenges such as how to effectively handle various Bayer patterns from different data sources, and subsequently how to perform valid data augmentation with raw images. To address the first problem, we propose a Bayer pattern unification (BayerUnify) method to unify different Bayer patterns. This allows us to fully utilize a heterogeneous dataset to train a single denoising model instead of training one model for each pattern. Furthermore, while it is essential to augment the dataset to improve model generalization and performance, we discovered that it is error-prone to modify raw images by adapting augmentation methods designed for RGB images. Towards this end, we present a Bayer preserving augmentation (BayerAug) method as an effective approach for raw image augmentation. Combining these data processing technqiues with a modified U-Net, our method achieves a PSNR of 52.11 and a SSIM of 0.9969 in NTIRE 2019 Real Image Denoising Challenge, demonstrating the state-of-the-art performance. Our code is available at https://github.com/Jiaming-Liu/BayerUnifyAug.Comment: Accepted by CVPRW 201

Accelerated quantum adiabatic transfer in superconducting qubits

Quantum adiabatic transfer is widely used in quantum computation and quantum simulation. However, the transfer speed is limited by the quantum adiabatic approximation condition, which hinders its application in quantum systems with a short decoherence time. Here we demonstrate quantum adiabatic state transfers that jump along geodesics in one-qubit and two-qubit superconducting transmons. This approach possesses the advantages of speed, robustness, and high fidelity compared with the usual adiabatic process. Our protocol provides feasible strategies for improving state manipulation and gate operation in superconducting quantum circuits

Dynamic Circular Network-Based Federated Dual-View Learning for Multivariate Time Series Anomaly Detection

Multivariate time-series data exhibit intricate correlations in both temporal and spatial dimensions. However, existing network architectures often overlook dependencies in the spatial dimension and struggle to strike a balance between long-term and short-term patterns when extracting features from the data. Furthermore, industries within the business community are hesitant to share their raw data, which hinders anomaly prediction accuracy and detection performance. To address these challenges, the authors propose a dynamic circular network-based federated dual-view learning approach. Experimental results from four open-source datasets demonstrate that the method outperforms existing methods in terms of accuracy, recall, and F1_score for anomaly detection

Tractography-Based Parcellation of Cerebellar Dentate Nuclei via a Deep Nonnegative Matrix Factorization Clustering Method

As the largest human cerebellar nucleus, the dentate nucleus (DN) functions significantly in the communication between the cerebellum and the rest of the brain. Structural connectivity-based parcellation has the potential to reveal the topography of the DN and enable the study of its subregions. In this paper, we investigate a deep nonnegative matrix factorization clustering method (DNMFC) for parcellation of the human DN based on its structural connectivity using diffusion MRI tractography. We propose to describe the connectivity of the DN using a set of curated tractography fiber clusters within the cerebellum. Experiments are conducted on the diffusion MRI data of 50 healthy adults from the Human Connectome Project. In comparison with state-of-the-art clustering methods, DN parcellations resulting from DNMFC show better quality and consistency of parcels across subjects