Decreased Peripheral BDNF Levels and Cognitive Impairment in Late-Life Schizophrenia

Objectives: There are relatively few studies on mechanisms of cognitive deficits in late-life schizophrenia (LLS). Brain-derived neurotrophic factor (BDNF), as an important neuroplastic molecule, has been reported to be involved in neurocognitive impairment in schizophrenia. This study aimed to examine whether peripheral BDNF levels were associated with cognitive deficits in LLS, which has not been explored yet.Methods: Forty-eight LLS patients and 45 age-matched elderly controls were recruited. We measured all participants on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition and serum BDNF levels. Psychopathological symptoms in patients were assessed by the Positive and Negative Syndrome Scale (PANSS).Results: The levels of BDNF in LLS patients were significantly lower than those in healthy controls (8.80 ± 2.30 vs. 12.63 ± 5.08 ng/ml, p < 0.001). The cognitive performance of LLS patients was worse than that of the controls on RBANS total score and scores of immediate memory, attention, language, and delayed memory (all p ≤ 0.005). BDNF was positively associated with attention in LLS patients (r = 0.338, p = 0.019).Conclusion: Our findings suggest that older patients with schizophrenia exhibit lower BDNF levels and more cognitive deficits than older controls, supporting the accelerated aging hypothesis of schizophrenia. Moreover, decreased BDNF is related to attention deficits, indicating that BDNF might be a candidate biomarker of cognitive impairments in LLS patients

Large magnetoresistance, structure and magnetic properties of the double perovskite LaKFe 1.2 Mo 0.8 O 6 compound

Abstract The double perovskite LaKFe 1.2 Mo 0.8 O 6 ceramics have been successfully synthesized. The structure, magnetic and transport properties of this compound have been studied. Its structure belongs to cubic system with space group Fm3m. Magnetization slowly reduced with temperature and large magnetoresistance of the sample under 1.0 T magnetic field remains constant around 0.95 in the studied temperature range. Magnetic field dependence of magnetoresistance is described and magnetoresistance increases abruptly under 0.65 T. The electrical transport properties can be described by the thermally activated hopping mechanism

Autocatalytic reduction-assisted synthesis of segmented porous PtTe nanochains for enhancing methanol oxidation reaction

Morphology engineering has been developed as one of the most widely used strategies for improving the performance of electrocatalysts. However, the harsh reaction conditions and cumbersome reaction steps during the nanomaterials synthesis still limit their industrial applications. Herein, one-dimensional (1D) novel-segmented PtTe porous nanochains (PNCs) were successfully synthesized by the template methods assisted by Pt autocatalytic reduction. The PtTe PNCs consist of consecutive mesoporous architectures that provide a large electrochemical surface area (ECSA) and abundant active sites to enhance methanol oxidation reaction (MOR). Furthermore, 1D nanostructure as a robust sustaining frame can maintain a high mass/charge transfer rate in a long-term durability test. After 2,000 cyclic voltammetry (CV) cycles, the ECSA value of PtTe PNCs remained as high as 44.47 m2·gPt–1, which was much larger than that of commercial Pt/C (3.95 m2·gPt–1). The high catalytic activity and durability of PtTe PNCs are also supported by CO stripping test and density functional theory calculation. This autocatalytic reduction-assisted synthesis provides new insights for designing efficient low-dimensional nanocatalysts

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

A Dynamically Adjusted Subspace Gradient Method and Its Application in Image Restoration

In this paper, a new subspace gradient method is proposed in which the search direction is determined by solving an approximate quadratic model in which a simple symmetric matrix is used to estimate the Hessian matrix in a three-dimensional subspace. The obtained algorithm has the ability to automatically adjust the search direction according to the feedback from experiments. Under some mild assumptions, we use the generalized line search with non-monotonicity to obtain remarkable results, which not only establishes the global convergence of the algorithm for general functions, but also R-linear convergence for uniformly convex functions is further proved. The numerical performance for both the traditional test functions and image restoration problems show that the proposed algorithm is efficient

A Salt-Assisted Combustion Method to Prepare Well-Dispersed Octahedral MnCr2O4 Spinel Nanocrystals

Well-dispersed nanocrystalline MnCr2O4 was prepared by a salt-assisted combustion process using low-toxic glycine as fuel and Mn(NO3)2 and Cr(NO3)3·9H2O as raw materials. The obtained products were characterized by X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) spectroscopy, Raman spectroscopy, Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM). The fabrication process was monitored by thermogravimetric and differential thermal analysis (TG-DTA). The phase formation process was detected by XRD, and MnCr2O4 single phase with high crystallinity was formed at 700°C. TEM and SEM images revealed that the products were composed of well-dispersed octahedral nanocrystals with an average size of 80 nm. Inert salt-LiCl played an important role in breaking the network structure of agglomerated nanocrystallites

Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits

Background Despite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS. Methods 32 geriatric male patients with schizophrenia (age >= 60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD. Results Patients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26 U/ml, p < .001). Except for the visuospatial index, the cognitive performance was significantly worse on RBANS total and other domain scores in the schizophrenia group than the control group. In the schizophrenia group, SOD levels were positively correlated with subscores of general psychopathology and negative symptoms and total scores of the PANSS (all p < .05), and inversely associated with performance in immediate memory, language, and RBANS total scores (all p < .05). Conclusions Our findings suggest that patients with LLS display disturbances in the antioxidant system, which may underlie the pathological process of cognitive impairments and negative symptoms in the late stage of schizophrenia. Supplementing with antioxidants could be a potential treatment