Karakteristik dan Pola Perambatan Komponen Pasang Surut di Perairan Selat Malaka, Laut Jawa, Laut Sulawesi dan Laut Flores

Penelitian ini berjudul Karakteristik Dan Pola Perambatan Komponen Pasang Surut Di Perairan Selat Malaka, Laut Jawa, Laut Sulawesi Dan Laut Flores. Tujuan dari penelitian ini adalah untuk mengetahui komponen harmonis pasang surut dan menganalisa pola perambatan komponen harmonis pasang surut pada tiap – tiap stasiun pasut di perairan Selat Malaka, Laut Jawa, Laut Sulawesi dan Laut Flores. Metode survei digunakan dalam penelitian ini untuk pengumpulan, pengolahan dan analisi data. Analisis data karakteristik dan pola perambatan komponen pasang surut di perairan Selat Malaka, Laut Jawa, Laut Sulawesi dan Laut Flores menggunakan metode analisis data deskriptif. Daerah di sekitar Selat Malaka mendapat pengaruh terbesar untuk komponen pasut ganda. Arah perambatan komponen pasang surut dipengaruhi oleh faktor kedalaman, kondisi perairan, bentuk pantai dan non-linear response dari perairan setempat

Pain management in lung cancer

  Lung cancer is the leading cause of cancer-related mortality worldwide. Not only burdened by the limited overall survival, lung cancer patient also suffer from various symptoms, such as pain, that implicated in the quality of life. Cancer pain is a complicated and transiently dynamic symptom that results from multiple mechanisms. This review will describe the pathophysiology of cancer pain and general approach in managing a patient with lung cancer pain. The use of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and adjuvant analgesia, as part of the pharmacology therapy along with interventional strategy, will also be discussed.

Perajin tradisional di daerah Propinsi Sulawesi Selatan

Tujuan perekaman ini pertama-tama adalah mendeskripsikan keberadaan berbagai perajin dan kerajinan tradisional pada berbagai kelompok masyarakat di Indonesia. Tujuan berikutnya adalah mengungkapkan ciri-ciri perajin dan kerajinan tradisional di Sulawesi Selatan untuk menemukan kaitannya dengan pembangunan sosial ekonomi dan budaya pada umumnya. Ruang lingkup perekaman tertulis ini adalah kerajinan tradisional di daerah Sulawesi Selatan. Aspek yang akan diungkapkan pada masing-masing kerajinan tradisional tersebut adalah perolehan bahan, teknologi dan peralatannya, modal dan tenaga kerja, produksi, distribusi, fungsi dan peranan sosial, ekonomi dan budaya hasil kerajinan tradisional baik bagi perajin maupun bagi konsumen. Lokasi cakupan yang menjadi sasaran perekaman ini adalah, pertama, pengrajin tenun sutera di Kelurahan Sompe, Kabupaten Wajo , kedua, perajin keramik tanah liat di Kelurahan Pattallasang, Kabupaten Takalar, ketiga, perajin ukiran kayu di Kelurahan Tikunna Melenong, Kabupaten Tanah Toraja, dan keempat, perajin pandai besi di Desa Massepe , Kabupaten Sidrap (Peta I)

The Correlation Of Age And Body Mass Index With The Level Of Both Protease MMP3 And Anti‑Protease TIMP‑1 Among Indonesian Patients With Chronic Obstructive Pulmonary Disease: A Preliminary Findings

Objectives: Individuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue degradation of lung extracellular matrix among COPD individuals. The purpose of the present study was to correlate age and/or BMI with salivary levels of MMP-3 and TIMP-1 among Indonesian subjects with COPD. Results: Thirty COPD patients were recruited to undergo thorough physical assessment and saliva collection for evaluating TIMP-1 and MMP-3 levels using commercially available kits enzyme-linked immunosorbent assay method. The mean (standard deviation) participant age and BMI were 60.5 (8.13) years, and 23.1 (4.75) kg/m , respectively. Furthermore, the mean (standard deviation) of TIMP-1 and MMP3 levels were 23.99 (6.85) ng/mL and 1.81 (1.167) μM, respectively. Age was negatively correlated with MMP-3 (P < 0.05), but not with TIMP-1 levels. Age and BMI were not correlated with TIMP-1 level (P > 0.05). Collectively, this study demonstrated that age has a negative correlation with the protease marker (i.e. MMP-3), but not the anti-protease marker (TIMP-1). BMI was not correlated with either protease/anti-protease marker among Indonesian subjects with COPD

Inter-Organizational Collaboration and Its Impact on the Effectiveness of Empowerment Programs in the Bulukumba, Bone, and Makassar Regions: A Comprehensive Study

This research aims to analyze the relationship between cross-organizational support and the effectiveness of empowerment programs in the Bulukumba, Bone, and Makassar regions. Using a qualitative method, the research was conducted from August to December 2022, with a focus on three pilot villages in South Sulawesi. With 15 key informants selected through purposive sampling, data were collected through in-depth interviews and observations. Data analysis involved stages of data reduction, data display, and conclusion drawing or verification.The results of this research reveal the importance of integrating physical, human, and social capital in community empowerment. It was found that the implementation of the program faced challenges in integrating these three capitals, often due to limitations in human resources and coordination among institutions. The Indonesia Juara program, which aims to develop an integrated empowerment model, encountered difficulties in applying these principles in the field. Furthermore, this study highlights the importance of the Pentahelix concept, which involves government, academia, business, communities, and media, in community empowerment. However, it was found that Pentahelix collaboration is still not optimal in practice, especially in the context of the Indonesia Juara program. Collaborative leadership is needed to enhance the effectiveness of this program by effectively integrating various stakeholders in empowerment efforts. It is recommended to promote stronger cooperation between Ministries/Institutions and Regional Device Organizations (OPD) to ensure program effectiveness and efficiency. Collaborative leadership is required to effectively integrate various stakeholders

Atrazine degradation by Bacillus safensis strain BUK_BCH_BTE6 isolated from agricultural land in northwestern Nigeria

Atrazine herbicide is known to disrupt the endocrine system and is potentially carcinogenic. Its continual application leads to high residue levels in soil, causing water pollution, which when consumed is associated with devastating health effects. This research reported the isolation and characterization of a new bacterial strains from active agricultural soil with the potential to biodegrade atrazine as a sole carbon source. An enrichment method was utilized to isolate the bacteria (A1, A2, B1, B2, C1 and C2) on mineral salt media (MSM) following serial dilution. Six isolates were screened for their tolerance to various concentrations of atrazine (500 to 1500 mg∙L‐1), and only isolate B1 tolerated up to 1500 mg∙L‐1 atrazine. The isolate was identified molecularly as Bacillus safensis strain BUK_BCH_BTE6 based on 16S rRNA gene sequencing and molecular phylogenetic analysis. Characterization of the isolate based on the effects of temperature, pH, substrate concentration, incubation time, inoculum size, and heavy metals revealed optimum growth and atrazine degradation at 35 °C, a pH of 7.5, 400 mg∙L‐1, at 48 h, and inoculum size of 600 µL, respectively. The growth of the isolate was inhibited by 2 ppm Hg, Cd, Cr, Pb, Ar, and Ni, while Fe, Cu, and Zn stimulated it. GC‐MS analysis revealed a degradation efficiency of 88.85% within 120 h, while metabolites such as desethyldeisopropylatrazine, deisopropylatrazine, N‐ethylammelide, and cyanuric acid were also detected. This isolate is a highly atrazine‐tolerant and efficient atrazine degrader that could be employed for bioremediation of atrazine‐polluted sites

Ruptured ectopic pregnancy presenting as an irreducible inguinal hernia

An inguinal hernia that suddenly becomes irreducible may be secondary to a variety of other underlying conditions which can occasionally mislead the attending surgeon. Benign, inflammatory or neoplastic processes, as well as surgical emergencies such as intraperitoneal or retroperitoneal haemorrhage, have all been previously reported to mimic an inguinal hernia that suddenly becomes irreducible with or without clinical features of strangulation. We add an additional interesting presentation to this list in the form of a ruptured ectopic pregnancy, which is the first such case reported in the literature. A swelling in the groin may be much more complicated than it seems on superficial consideration and good clinical acumen is constantly required in managing such cases if a satisfactory outcome without any morbidity is to be expected

Association of Tumor Necrosis Factor Alpha and Lymphotoxin Alpha Gene Polymorphisms with the Presence of Chronic Obstructive Pulmonary Disease

Aim: to analyze the occurrence of chronic obstructive pulmonary disease (COPD) and its association with the polymorphisms of -308G/A, -238G/A of TNFα gene and +252A/G LTα gene polymorphism in smokers. Methods: cross-sectional study, comparing the genetic group of people who have COPD and who do not have COPD with the same smoking history. The study was conducted from January 2011 to March 2012 at several health centers; such as Adam Malik Hospital, Pirngadi Hospital, Tembakau Deli Hospital, Siti Hajar Hospital in Medan and several health centers in the city of Medan. Examination of lung function was done using spirometry and the existence of genetic polymorhisms in the TNFα and LTα gene was performed using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Results: of the total of 227 samples that met inclusion criteria and after equalizing the age and history of smoking, 186 subjects were enrolled, of which, 93people as COPD group and 93 people as non-COPD group. Analysis of the association between the -308G/A polymorphism with the COPD revealed the odds ratio (OR) 0.436 (95% CI 0.224-0.850, p=0.014). Polymorphism at -238G/A of the TNFα gene showed the OR 2.094 (95% CI 0.608 - 7.211, p=0.241). Polymorphism at +252A/G LTα gene showed OR 1.256 (95% CI 0.694 - 2.272; p=0.450). The findings indicated that polymorphism at -308G showed a protective factor whereas the -238G/A of the TNFα and +252A/G of the LTα genes did not show any significant association with the COPD. Conclusion: polymorphism -308 TNFα gene shown to be a protective factor for the occurrence of COPD. Polymorphism -238 TNFα gene and +252 LTα gene did not show any significant association with COPD.Key words: chronic obstructive pulmonary disease, TNFα gene, LTα gene, polymorphism

The Balance between Interleukin 5 and Interleukin 10 Level in Persistent Atopic Asthma after House Dust Mite Allergen Dermatophaigoides pteronyssinus (Der p) Stimulation

Asthma is a chronic inflammation of the respiratory tract characterized by coughing, shortness of breath, wheezing and limited expiratory airflow. Interleukin 10 (IL-10) is a cytokine produced by T regulators which functions to suppress pro-inflammatory production and development. Interleukin 5 (IL-5) is glycoprotein produced by Th2 which acts as a proinflammatory agent. This study aimed to analyze how to balance between IL-10 and IL-5 levels on persistent atopic asthma. The study design was an experimental research method with invitro study used isolation and cell culture of Peripheral Blood Mononuclear Cell (PBMC) with negative control Roswell Park Memorial Institute (RPMI) medium, positive control Phytohaemaglutinin (PHA) and house dust mite allergen stimulation 10 µl. This study involved 39 samples asthmatic. There was a significant increase in IL-5 levels after stimulation of house dust mite allergens with p: 0.000; there was a significant decrease in IL-10 levels after house dust mite allergen stimulation with p: 0.000. Our study suggests that IL-5 and IL-10 balance is related to persistent atopic asthma after house dust mite allergen Der p stimulation. Keywords: Interleukin 5, Interleukin 10, Atopic Asthma, house dust mite allergen, ELIS