15 research outputs found

    A Competência em Informação (Coinfo) na perspectiva da educação inclusiva

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    Tese (doutorado)—Universidade de Brasília, Faculdade de Ciência da Informação, Programa de Pós-Graduação em Ciência da Informação, 2017.Discute os desafios da sociedade da informação no que tange à promoção e garantia de uma educação inclusiva a partir de uma agenda estabelecida em ambiências supranacionais, internacionais e multilaterais. Destaca a necessidade de formação de professores para lidar com necessidades informacionais emergentes da prática educativa, em especial quando aplicada a pessoas com deficiência. Neste contexto, situa nos aspectos interdisciplinares entre Ciência da Informação e Educação, contribuições relacionadas tanto à inclusão quanto à atuação de docentes da Educação Básica. Admite os pressupostos teóricos e práticos da temática Competência em Informação – termo adotado para o conceito de Information Literacy – como alternativa de formação de docentes da Educação Básica na perspectiva de uma educação inclusiva. Propõe a utilização de um percurso metodológico baseado nas contribuições de estudos sobre o Paradigma Indiciário de Ginzburg o qual é composto por uma fase exploratória e uma fase aplicada. Na fase exploratória utiliza a produção científica de Ciência da Informação, especialmente nos trabalhos divulgados no Encontro Nacional de Pesquisa e Pós graduação em Ciência da Informação para identificar tendências de pesquisa sobre Competência em Informação e possíveis relações com a inclusão. Discute estas tendências relacionando-as com a tridimensionalidade que o termo inclusão propõe, a saber, inclusão social, inclusão digital e inclusão relacionada a pessoas com deficiência. Realiza a aplicação de pré testes (denominados de Pré Testes Indiciais) em situações de formação de professores. Adicionalmente analisa 18 modelos de Competência em Informação desenvolvidos em contextos internacionais cuja síntese permitiu propor grade básica para elaboração de um modelo de Competência em Informação. Na fase aplicada admite a influência teórica de conceitos de mediação como norteador da prática. Adicionalmente utiliza como método de abordagem a problematização e como técnica o desenvolvimento de um curso de formação de professores com 22 professores de uma escola púbica do Distrito Federal. Utilizou recursos didáticos originais elaborados para esta pesquisa, combinados com procedimentos de utilização e avaliação do modelo pedagógico para formação de professores em Competência em Informação numa perspectiva inclusiva. Na fase aplicada analisa a utilização deste modelo nas atividades, objetivos e habilidades propostas nas três etapas em que se estrutura, nomeadamente, pré-busca, busca propriamente dita e pós-busca. As atividades foram desenvolvidas e analisadas principalmente nas duas etapas do modelo- pré-busca e busca. Atividades de pós-busca não foram realizadas, visto que exigiriam abordagem longitudinal. Os resultados das atividades mostraram que a proposta pedagógica desenvolvida e aplicada é útil para a formação de professores de Educação Básica, em Competência em Informação numa perspectiva inclusiva.This research discusses the challenges of the information society regarding the promotion and assurance of an inclusive education based on an agenda established in supranational, international and multilateral environments. It highlights the need for teacher training to deal with informational needs emerging from educational practice, especially when applied to people with disabilities. In this context, it focuses on the interdisciplinary aspects between Information Science and Education contributions related to the inclusion and also the performance of Basic Education teachers. It admits the theoretical and practical assumptions of the theme Information Competency - a term adopted to the Information Literacy concept - as an alternative to Basic Education teachers’ training from the perspective of an inclusive education. It offers the use of a methodological path based on the contributions from studies on the Ginzburg Evidential Paradigm which is composed by an exploratory phase and an applied phase. In the exploratory phase it uses the scientific production of Information Science, especially in the works published in the National Meeting of Research and Postgraduate in Information Science to identify research trends about Information Competency and its possible relation to inclusion. It discusses those trends by relating them to the tridimensionality proposed by the term inclusion, namely, social inclusion, digital inclusion and inclusion related to people with disabilities. It performs the application of pre-tests (called Evidential Pre-tests) in situations of teacher training. Additionally it analyzes 18 models of Information Competency developed in international contexts which synthesis allowed proposing a basic grade to elaborate an Information Competency model. In the applied phase, it admits the theoretical influence of mediation concepts as a guide to the practice. Additionally it uses the problematization as an approach method and as technique the development of a teacher training course with 22 teachers from a public school in the Federal District. It used original didactic resources elaborated for this research combined with use and evaluation procedures of the pedagogical model for teachers’ training in Information Competency through an inclusive perspective. In the applied phase, it analyzes the use of this model on the activities, goals and abilities proposed through the three stages in which it is structured, namely pre-search, search itself and post-search. The activities were developed and analyzed mainly in the model stages of pre-search and search. Post-search activities were not performed, as they would require a longitudinal approach. The results of the activities showed that the pedagogical proposal developed and applied is useful to Basic Education teachers’ training in Information Competency through an inclusive perspective

    Effect of DSHT on leptin and adiponectin gene expressions in HFD-fed C57BL/6j mice.

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    <p>(A) Folds changes in leptin gene expression in normal (NOR), high fat diet (HFD), orilistat (ORL), and daesiho-tang (DSHT) fed animals after 12 weeks. (B) adiponectin gene expression in NOR, HFD, HFD+ORL and HFD+DSHT treated animals. Data were represented as mean ± SD (<i>n</i> = 4). The results were compared by Student’s <i>t</i>-test (* corresponds to <i>p</i><0.05). The error bars represent the SD.</p

    Daesiho-Tang Is an Effective Herbal Formulation in Attenuation of Obesity in Mice through Alteration of Gene Expression and Modulation of Intestinal Microbiota

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    <div><p>Background</p><p>Obesity has become a major global health challenge due to its increasing prevalence, and the associated health risk. It is the main cause of various metabolic diseases including diabetes, hypertension, cardiovascular disease, stroke and certain forms of cancer.</p><p>Methods and Results</p><p>In the present study we evaluated the anti-obesity property of Daesiho-tang (DSHT), an herbal medicine, using high fat diet (HFD)-induced obese mice as a model. Our results showed that DSHT ameliorated body weight gain, decreased total body fat, regulated expression of leptin and adiponectin genes of adipose tissue and exerted an anti-diabetic effect by attenuating fasting glucose level and serum insulin level in HFD-fed animals. In addition, DSHT-treatment significantly reduced total cholesterol (TC), triglycerides (TG) and increased high density lipoprotein-cholesterol (HDL), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) levels in serum and reduced deposition of fat droplets in liver. DSHT treatment resulted in significantly increased relative abundance of bacteria including <i>Bacteroidetes</i>, Bacteroidetes/Firmicutes ratio, <i>Akkermansia Bifidobacterium</i>., <i>Lactobacillus</i>, and decreased the level of Firmicutes. Using RT2 profiler PCR array, 39 (46%) genes were found to be differentially expressed in HFD-fed mice compared to normal control. However, normal gene expressions were restored in 36 (92%) genes of HFD-fed mice, when co-exposed to DSHT.</p><p>Conclusion/Major Findings</p><p>The results of this study demonstrated that DSHT is an effective herbal formulation in attenuation of obesity in HFD-fed mice through alteration of gene expressions and modulation of intestinal microbiota.</p></div

    Effect of DSHT on expressions of lipid and cholesterol metabolism genes in HFD-fed c57bl/6j mice.

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    <p>(A) Hierarchical clustering of gene expressions of mouse fed on HFD, DSHT, ORL and NOR detected by RT2 PCR array. The dendrogram at the left provides a measure of relatedness of gene expression in each group. (B) The interconnected pathway of genes differentially expressed in RT2 PCR array.</p

    Effect of DSHT on leptin and adiponectin gene expressions in HFD-fed C57BL/6j mice.

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    <p>(A) Folds changes in leptin gene expression in normal (NOR), high fat diet (HFD), orilistat (ORL), and daesiho-tang (DSHT) fed animals after 12 weeks. (B) adiponectin gene expression in NOR, HFD, HFD+ORL and HFD+DSHT treated animals. Data were represented as mean ± SD (<i>n</i> = 4). The results were compared by Student’s <i>t</i>-test (* corresponds to <i>p</i><0.05). The error bars represent the SD.</p

    Effect of DSHT on HFD-induced histopathological changes of liver tissue stained with oil red O staining.

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    <p>(A) Representative image of liver tissue of normal control animal (NOR) stained with Oil red O. (B) Representative image of liver tissue of animals treated with HFD. (C) Representative image of liver tissue of animals treated HFD+ORL. (D) Representative image of liver tissue of HFD<b>+</b>DSHT treated animals. Pathophysiological examination of the tissue sections was performed under light microscopy with 200x magnification.</p

    Effect of DSHT on expressions of lipid and cholesterol metabolism genes in HFD-fed c57bl/6j mice.

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    <p>(A) Hierarchical clustering of gene expressions of mouse fed on HFD, DSHT, ORL and NOR detected by RT2 PCR array. The dendrogram at the left provides a measure of relatedness of gene expression in each group. (B) The interconnected pathway of genes differentially expressed in RT2 PCR array.</p

    Effect of DSHT on total body weight (gain), liver weight, intestinal and total fat of HFD-fed C57BL/6 mice.

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    <p>(A) Total body weight of normal (NOR), high fat diet (HFD), orilistat (ORL) or daesiho-tang (DSHT) fed animals measured weekly. (B) The total body weight of NOR, HFD, HFD+ORL and HFD+DSHT fed animals after 12 weeks. (C) The liver weight of NOR, HFD, HFD+ORL and HFD+DSHT diet fed animals. (D) Intestinal fat of NOR, HFD, HFD+ORL and HFD+DSHT fed animals. (E) The total fat of NOR, HFD, HFD+ORL and HFD+DSHT fed animals. Data were represented as mean ± SD (<i>n</i> = 7). The results were compared by Student’s <i>t</i>-test (** corresponds to <i>p</i><0.005, * corresponds to <i>p</i><0.05). The error bars represent the SD.</p
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