Determinación de escenarios de inundaciones en la subcuenca del río Cunas, Junín, Perú

Se presenta una metodología basada en el procesamiento del modelo digital del terreno en SAGA-GIS para determinar los escenarios de inundaciones en caso de lluvias intensas o prolongadas en la subcuenca del río Cunas, Junín, Perú. Las variables calculadas a partir del DTM ALOS PALSAR fueron: Depresiones cerradas (CD), Distancia vertical a la red de drenaje (VD), Área de captación modificada (MCA), Escorrentía superficial - Escorrentía terrestre flujo D8, y el índice de humedad topográfico (TW1). La susceptibilidad a las inundaciones se obtiene como CD + MCA + D8 + TW1- VD. El mapa resultante validado en el campo, muestra diferentes grados de susceptibilidad a inundaciones, destacando tres sectores donde un grupo significativo de núcleos de población se encuentran expuestos a potenciales inundaciones de grado medio a alto

Determinación de escenarios de inundaciones en la subcuenca del río Cunas, Junín, Perú

Se presenta una metodología basada en el procesamiento del modelo digital del terreno en SAGA-GIS para determinar los escenarios de inundaciones en caso de lluvias intensas o prolongadas en la subcuenca del río Cunas, Junín, Perú. Las variables calculadas a partir del DTM ALOS PALSAR fueron: Depresiones cerradas (CD), Distancia vertical a la red de drenaje (VD), Área de captación modificada (MCA), Escorrentía superficial - Escorrentía terrestre flujo D8, y el índice de humedad topográfico (TW1). La susceptibilidad a las inundaciones se obtiene como CD + MCA + D8 + TW1- VD. El mapa resultante validado en el campo, muestra diferentes grados de susceptibilidad a inundaciones, destacando tres sectores donde un grupo significativo de núcleos de población se encuentran expuestos a potenciales inundaciones de grado medio a alto

Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.Revisión por pare

Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties

Vulnerabilidad ante desastres naturales: una visión desde el enfoque socio-comunicacionalalgunas consideraciones sobre gestión de riesgos naturales en Perú.

Every year in the world thousands of lives are lost as a result of natural disasters, many of them derived from the lack of knowledge of phenomena and others due to the existing social reality, for these reasons, this article seeks to reflect on human vulnerability to natural disasters, from the socio-communicational perspective, taking as reference some considerations in Peru. For this, the documentary methodology of phenomenology was used, assuming a heuristic position of the field of critical rationality. The findings made it possible to determine «sine controversia» that natural phenomena are irreducible, therefore, a disaster management system focused on a socio-communicational approach will reduce vulnerability, based on mass communication to educate citizens, information systems technology to reduce tensions during the catastrophe and an emergency social information model for the recovery of the impacted territory with community resilience. These elements must be considered to reorganize the disaster management communication policy carried out by SINAGERD in PeruCada año en el mundo se pierden miles de vidas como consecuencia de desastres naturales, muchos de ellos derivados por el desconocimiento de los fenómenos y otros por la realidad social existente, por estos causales, este articulo procura reflexionar sobre la vulnerabilidad humana ante los desastres naturales, desde la perspectiva socio-comunicacional, tomando como referencia algunas consideraciones en Perú. Para ello, se usó la metodología documental de la fenomenología asumiendo una postura heurística del campo de la racionalidad crítica. Los hallazgos permitieron determinar «sine controversia» que los fenómenos naturales son irreducibles, por tanto, un sistema de gestión de desastre centrado en un enfoque socio-comunicacional permitirá reducir la vulnerabilidad, fundamentado en la comunicación en masa para educar al ciudadano, sistemas de información tecnológica para reducir las tensiones durante la catástrofe y un modelo de información social de emergencia para la recuperación del territorio impactado con resiliencia comunitaria. Estos elementos deben ser considerados para reorganizar la política comunicacional de gestión de desastres que lleva a cabo el SINAGERD en el Perú&nbsp; &nbsp;&nbsp;&nbsp;&nbsp

Daytime perimeter environmental noise in the vicinity of four hospitals in the city of Lima, Peru

The present study is intended to get to know thelevels of perimeter diurnal environmental noise of fourhospitals in the city of Lima. The measurement mode usedat each hospital was A-weighting, with an integration timeof five minutes per recording. It was measured in the FASTmode with calibrations made at the beginning and end ofthe measurement day. Statistical analysis consisted of themean comparison T test which was applied at all the hospi-tals considered in the study. At the four hospitals, at all thehours of measurement and both on working days and non-working days (Sunday), LAeq mean values are higher than83 dBA. On working days, two periods of maximum noisefrom 08:00 to 10:00 in the morning and from 17:00 to 19:00in the afternoon coincide with the start and end of workinghours. The perimeter diurnal environmental noise levelsdetermined at the vicinity of four hospitals show highervalues in all cases to those established by the Peruvian Na-tional Environmental Standards for Noise for special pro-tection areas both for working days and for non-workingdays. Noise that comes from the dense and disorganizedtraffic of Lima plays a fundamental role in this behaviou

Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties

Antioxidant and Cytoprotective Effect of <i>Piper aduncum</i> L. against Sodium Fluoride (NaF)-Induced Toxicity in Albino Mice

Piper aduncum, commonly known as matico, is a plant that grows in the mountainous and coastal regions of Peru, and is studied for its antimicrobial properties and various ethnopharmacological uses. The main objective of this study was to determine the cytoprotective and antioxidant effects of the methanolic extract of Piper aduncum leaves in Mus musculus previously administered with sodium fluoride (NaF) using the Micronucleus test and the Comet assay. The extract was administrated orally in four different concentrations: 150, 300, 600, and 1200 mg/Kg for ten days. At the 11th day, a single dose of NaF was administrated via intraperitoneal at 20 mg/Kg. The genotoxicity study was performed with mice from the strain BALB/c, using the Micronucleus test on bone marrow and the Comet assay on peripheral blood according to OECD guidelines 474 and 489, respectively. The statistical analysis was performed by median analysis with ANOVA. Significant differences were found in Micronucleus frequency between the highest concentrations of Piper aduncum and NaF. The Comet assay showed significant reduction of NaF-induced damage on erythrocytes depending on the different concentrations of the extract which were evaluated in this study. It is concluded that the methanolic extract of P. aduncum leaves has cytoprotective and antioxidant activity against sodium fluoride