1,260 research outputs found
Relationship among Self-appraisals, Othersā Actual Appraisals, and Reflected Appraisals on Primary School Teachers Teaching Ability
Convenient sampling and questionnaire survey was used to investigate the relationship among self-appraisals, othersā actual appraisals, and reflected appraisals on the teaching ability of 40 primary school teachers. The results of the study indicated that primary school teachersā selfappraisals on teaching ability was obviously below othersā actual appraisals; generalized others had more influence on the self-appraisals of primary school teachers than specific others; primary school teachersā reflected appraisals could influence their self-appraisals; and othersā actual appraisals could not directly influence self-appraisals. Consequently, we should pay more attention in developing the primary school teachersā reflective ability, change the current way of teaching reflection, improve the influence of othersā actual appraisals on self-appraisals, and enhance the validity of teaching reflection
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here, we found that miR-181a was upregulated in hydrogen peroxide (
Recommended from our members
Association of Mitochondrial DNA Polymerase Ī³ Gene <i>POLG1</i> Polymorphisms with Parkinsonism in Chinese Populations
Background: Mitochondrial DNA polymerase gamma (POLG1) mutations were associated with levodopa-responsive Parkinsonism. POLG1 gene contains a number of common nonsynonymous SNPs and intronic regulatory SNPs which may have functional consequences. It is of great interest to discover polymorphisms variants associated with Parkinson's disease (PD), both in isolation and in combination with specific SNPs.Materials and Methods: We conducted a case-control study and genotyped twenty SNPs and poly-Q polymorphisms of POLG1 gene including in 344 Chinese sporadic PD patients and 154 healthy controls. All the polymorphisms of POLG1 we found in this study were sequenced by PCR products with dye terminator methods using an ABI-3100 sequencer. Hardy-Weinberg equilibrium and linkage disequilibrium (LD) for association between twenty POLG1 SNPs and PD were calculated using the program Haploview.Principal Results: We provided evidence for strong association of four intronic SNPs of the POLG1 gene (new report: c.2070-12T>A and rs2307439: c.2070-64G>A in intron 11, Pā=ā0.00011, ORā=ā1.727; rs2302084: c.3105-11T>C and rs2246900: c.3105-36A>G in intron 19, Pā=ā0.00031, ORā=ā1.648) with PD. However, we did not identify any significant association between ten exonic SNPs of POLG1 and PD. Linkage disequilibrium analysis indicated that c.2070-12T>A and c.2070-64G>A could be parsed into one block as Haplotype 1 as well as c.3105-11T>C and c.3105-36A>G in Haplotype 2. In addition, case and control study on association of POLG1 CAG repeat (poly-Q) alleles with PD showed a significant association (Pā=ā0.03, ORā=ā2.16) of the non-10/11Q variants with PD. Although intronic SNPs associated with PD didn't influence POLG1 mRNA alternative splicing, there was a strong association of c.2070-12T>A and c.2070-64G>A with decreased POLG1 mRNA level and protein levels.Conclusions: Our findings indicate that POLG1 may play a role in the pathogenesis of PD in Chinese populations.</p
q-Deformation of W(2,2) Lie algebra associated with quantum groups
An explicit realization of the W(2,2) Lie algebra is presented using the
famous bosonic and fermionic oscillators in physics, which is then used to
construct the q-deformation of this Lie algebra. Furthermore, the quantum group
structures on the q-deformation of this Lie algebra are completely determined.Comment: 12 page
Tunable hysteresis effect for perovskite solar cells
Perovskite solar cells (PSCs) usually suffer from a hysteresis effect in currentāvoltage measurements,
which leads to an inaccurate estimation of the device e
fficiency. Although ion migration, charge trapping/
detrapping, and accumulation have been proposed as a b
asis for the hysteresis, the
origin of the hysteresis
has not been apparently unraveled. Herein we reporte
d a tunable hysteresis effect based uniquely on open-
circuit voltage variations in printable mesos
copic PSCs with a simplified triple-layer TiO
2
/ZrO
2
/carbon
architecture. The electrons are collected by the compact TiO
2
/mesoporous TiO
2
(c-TiO
2
/mp-TiO
2
)bilayer,
and the holes are collected by the carbon layer. By adj
usting the spray deposition cycles for the c-TiO
2
layer
andUV-ozonetreatment,weachievedhysteresis-norm
al, hysteresis-free, and hysteresis-inverted PSCs.
Such unique trends of tunable hysteresis are anal
yzed by considering the polarization of the TiO
2
/perovskite
interface, which can accumulate positive charges reversibly. Successfully tuning of the hysteresis effect
clarifies the critical importance of the c-TiO
2
/perovskite interface in controlling the hysteretic trends
observed, providing important insights towards the understanding of this rapidly developing photovoltaic
technology
Temperature-based Collision Detection in Extreme Low Light Condition with Bio-inspired LGMD Neural Network
It is an enormous challenge for intelligent vehicles to avoid collision accidents at night because of the extremely poor light conditions. Thermal cameras can capture temperature map at night, even with no light sources and are ideal for collision detection in darkness. However, how to extract collision cues efficiently and effectively from the captured temperature map with limited computing resources is still a key issue to be solved. Recently, a bio-inspired neural network LGMD has been proposed for collision detection successfully, but for daytime and visible light. Whether it can be used for temperature-based collision detection or not remains unknown. In this study, we proposed an improved LGMD-based visual neural network for temperature-based collision detection at extreme light conditions. We show in this study that the insect inspired visual neural network can pick up the expanding temperature differences of approaching objects as long as the temperature difference against its background can be captured by a thermal sensor. Our results demonstrated that the proposed LGMD neural network can detect collisions swiftly based on the thermal modality in darkness; therefore, it can be a critical collision detection algorithm for autonomous vehicles driving at night to avoid fatal collisions with humans, animals, or other vehicles
Immunity duration of a recombinant adenovirus type-5 vector-based Ebola vaccine and a homologous prime-boost immunisation in healthy adults in China: fi nal report of a randomised, double-blind, placebo-controlled, phase 1 trial
Background The 2013ā15 Ebola virus disease epidemic in west Africa greatly accelerated the development of Ebola
vaccine. We aimed to analyse the immune persistence induced by one shot of an adenovirus type-5 vector-based
Ebola virus vaccine up to 6 months and the eff ect of boosting with a homologous vector in healthy adults in China.
Methods In a randomised, double-blind, placebo-controlled, phase 1 clinical trial in one site in Jiangsu Province,
China, 120 healthy adults aged 18ā60 years received an initial dose of intramuscular adenovirus type-5 Ebola virus
vaccine of 4Ā·0 Ć 10Ā¹ā° viral particles, 1Ā·6 Ć 10Ā¹Ā¹ viral particles, or placebo, and were followed up to day 168. Participants
were subsequently re-recruited to receive a booster dose of the same vaccine or placebo, in the same dose, at month 6.
Women who were pregnant, breastfeeding, or planned to become pregnant during the next month were excluded.
Randomisation was conducted by computer-generated block randomisation. Randomisation data were unmasked for
interim analysis of the data obtained between days 0ā28 but not disclosed to participants or site staff . Safety and
immunogenicity analysis were done on the intention-to-treat population. We aimed to assess the safety profi le of the
experimental vaccine and the immunity responses to a single-dose immunisation or a homologous prime-boost
regimen. Primary outcomes were Ebola glycoprotein-specifi c ELISA antibody responses 28 days post-boost and the
occurrences of adverse reactions post-boost. The original trial and the extended booster study were registered with
ClinicalTrials.gov, numbers NCT02326194 and NCT02533791, respectively.
Findings Between Dec 28, 2014, and Jan 9, 2015, we enrolled 210 volunteers. 90 participants were not randomised due
to not meeting inclusion criteria (61), meeting exclusion criteria (4), or withdrawal of consent (25). 120 people were
randomly assigned to receive intramuscular Ebola vaccine at 4Ā·0 Ć 10Ā¹ā° viral particles (low dose, n=40), Ebola vaccine
at 1Ā·6 Ć 10Ā¹Ā¹ viral particles (high dose, n=40), or placebo (n=40, in two groups of 20). After prime vaccination, the
geometric mean titer (GMT) of ELISA EC90 peaked at 682Ā·7 (95% CI 424Ā·3ā1098Ā·5) in the low-dose vaccine group
and 1305Ā·7 (970Ā·1ā1757Ā·2) in the high-dose vaccine group at day 28, and then fell gradually through the next a few
months to 575Ā·5 (394Ā·8ā838Ā·8) in the high-dose vaccine group and 197Ā·9 (107Ā·9ā362Ā·7) in the low-dose vaccine
group at day 168. No specific response was recorded in the placebo group with a GMT of 5Ā·0. Of the 120 participants
involved in the initial trial, ten participants declined to participate, and 110 were included in the boost immunisation:
38 received the low dose, 35 received the high dose, and 37 received the placebo. At day 28 after boost vaccination, the
ELISA EC90 titres rapidly rose to 6110 (95% CI 4705ā7935) in the low-dose group and to 11825 (8904ā15705) in the
high dose group. 78 of 110 participants reported at least one solicited adverse reaction within the fi rst 7 days after
booster administration. Both of the groups who received vaccine showed signifi cantly higher incidence of mild or
moderate solicited adverse reactions than did the placebo group.
Interpretation The adenovirus 5-vectored Ebola vaccine of 1Ā·6 Ć 10Ā¹Ā¹ viral particles was highly immunogenic and
safe. The lower dose of 4Ā·0 Ć 10Ā¹ā° viral particles was also safe, but immunogenicity seemed to be more vulnerable
to the pre-existing immunity of adenovirus 5. A homologous priming-boosting regimen with adenovirus type-5
Ebola vaccine at 6 months interval was able to elicit greater antibody responses with longer duration. These results
support an immunisation strategy to implement a booster injection for a more durable protection against Ebola
virus disease
- ā¦