Integrated design and Research on driving and controlling structure of robot intelligent joint

at present, the robot industry is widely concerned in China, and there are more robot production and R & D enterprises. However, robots are subject to many restrictions in the application process, including industry development, enterprise structure, robot R & D and robot manufacturing. Many small enterprises have a series of characteristics such as low production and short cycle, so it is necessary to continuously optimize and update the robot to meet the needs of enterprises. The emergence of integrated design of drive control structure can eff ectively solve these problems. In the current development process, there is a high demand for the personalization and intelligence of robots. Therefore, this paper designs and studies the drive control structure integration of robot intelligent joint, in order to promote the development of robot industry

Exploration on new ideas of robot teaching reform in Colleges and universities

with the proposal of intelligent manufacturing 2025 action program, it points out the development direction for the transformation and upgrading of China’s manufacturing industry, and also gives suffi cient power to relevant industries. The research on the cultivation of innovative engineering science and technology talents in the Chinese Academy of engineering has shown that China’s future modernization and economic development need scientifi c and technological talents with diversifi ed attributes, which also puts forward new requirements for robot teaching and talent cultivation in relevant colleges and universities. In view of this, in the process of robot teaching, it is necessary for university teachers to innovate their teaching ideas, improve the quality of professional teaching, break through the shackles of traditional teaching, build an effi cient talent training system through the integration of modern teaching ideas, complete the reform and innovation of robot teaching, and cultivate more talents with social developmentPractical professional talents suitable for the development of the industry. Based on this, this paper analyzes the current situation of robot teaching in Colleges and universities, and puts forward some ideas and suggestions for the teaching reform, in order to add fuel and raise wages for the teaching reform of robot in Colleges and universities

Is I-Voting I-Llegal?

The Voting Rights Act was passed to prevent racial discrimination in all voting booths. Does the existence of a racial digital divide make Internet elections for public office merely a computer geek\u27s pipe dream? Or can i-voting withstand scrutiny under the current state of the law? This i-Brief will consider the current state of the law, and whether disproportionate benefits will be enough to stop this extension of technology dead in its tracks

Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.

Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells. The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-κB proteins, and abrogated the binding of NF-κB on COX-2 promoter. Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy

Rational Design of a Two-Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism-Based Inactivation

Mechanism-based inactivation (MBI) can mediate adverse reactions and hepatotoxicity from drugs, which is a result of their conversion into highly reactive metabolites catalyzed by enzymes such as cytochrome P450 3A (CYP3A). In the present research, we optimized the key interaction domain of the fluorophore with the target protein to develop a two-photon fluorescent probe for CYP3A that is involved in the metabolism of more than half of all clinical drugs. The developed BN-1 probe exhibited appropriate selectivity and sensitivity for the semi-quantitative detection and imaging of endogenous CYP3A activity in various living systems, thereby providing a high-throughput screening system enabling evaluation of MBI-associated hepatotoxicity by CYP3A. Using BN-1 as a fluorescent molecular tool facilitates the efficient discovery and characterization of CYP3A-induced MBI in natural systems.</p

Alginate oligosaccharides improve hepatic metabolic disturbance via regulating the gut microbiota

peer reviewedAlginate oligosaccharides (AOS) derived from sodium alginate are novel prebiotics with multiple biological functions. Low birth weight (LBW) is a public health concern worldwide. However, the benefits of AOS in LBW mammals have not been determined. In this study, we found that AOS significantly improved the growth performance, colonic mucosal immunity, and jejunal nutrient digestion and transport of LBW piglets. Moreover, AOS alleviated liver injury by alleviating oxidative stress and pro-inflammatory responses, and improved hepatic lipid accumulation and insulin resistance by decreasing the levels of genes involved in lipid transport, de novo lipogenesis, and the insulin signaling. Integrated 16S rDNA, transcriptome, and metabolome analyses revealed that AOS alleviated the disruption of colonic mucosal immunity by increasing the abundance of Lactobacillus and short-chain fatty acids, and improved hepatic dysfunction via the tryptophan metabolites and aryl hydrocarbon receptor signaling. These findings revealed the effects and mechanisms of AOS in intestinal and hepatic dysfunction in LBW piglets, and broadened the potential application of AOS in improving postnatal maldevelopment in LBW infants

Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its biological role in tumorigenesis and cancer diagnosis remains poorly understood, owing to the lack of molecular tools suitable for real-time monitoring CYP2J2 in complex biological systems. Using molecular design principles we were able to modify the distance between the catalytic unit and metabolic recognition moiety, allowing us to develop a CYP2J2 selective fluorescent probe using a near-infrared fluorophore (E)-2-(2-(6-hydroxy-2, 3-dihydro-1H-xanthen-4-yl)vinyl)-3,3- dimethyl-1-propyl-3H-indol-1-ium iodide (HXPI). To improve the reactivity and isoform specificity, a self-immolative linker was introduced to the HXPI derivatives in order to better fit the narrow substrate channel of CYP2J2, the modification effectively shortened the spatial distance between the metabolic moiety (O-alkyl group) and catalytic center of CYP2J2. After screening a panel of O-alkylated HXPI derivatives, BnXPI displayed the best combination of specificity, sensitivity and applicability for detecting CYP2J2 in vitro and in vivo. Upon O-demethylation by CYP2J2, a self-immolative reaction occurred spontaneously via 1,6-elimination of p-hydroxybenzyl resulting in the release of HXPI. Allowing BnXPI to be successfully used to monitor CYP2J2 activity in real-time for various living systems including cells, tumor tissues, and tumor-bearing animals. In summary, our practical strategy could help the development of a highly specific and broadly applicable tool for monitoring CYP2J2, which offers great promise for exploring the biological functions of CYP2J2 in tumorigenesis.</p

Deep Learning Application in Security and Privacy - Theory and Practice:A Position Paper

Technology is shaping our lives in a multitude of ways. This is fuelled by a technology infrastructure, both legacy and state of the art, composed of a heterogeneous group of hardware, software, services and organisations. Such infrastructure faces a diverse range of challenges to its operations that include security, privacy, resilience, and quality of services. Among these, cybersecurity and privacy are taking the centre-stage, especially since the General Data Protection Regulation (GDPR) came into effect. Traditional security and privacy techniques are overstretched and adversarial actors have evolved to design exploitation techniques that circumvent protection. With the ever-increasing complexity of technology infrastructure, security and privacy-preservation specialists have started to look for adaptable and flexible protection methods that can evolve (potentially autonomously) as the adversarial actor changes its techniques. For this, Artificial Intelligence (AI), Machine Learning (ML) and Deep Learning (DL) were put forward as saviours. In this paper, we look at the promises of AI, ML, and DL stated in academic and industrial literature and evaluate how realistic they are. We also put forward potential challenges a DL based security and privacy protection technique has to overcome. Finally, we conclude the paper with a discussion on what steps the DL and the security and privacy-preservation community have to take to ensure that DL is not just going to be hype, but an opportunity to build a secure, reliable, and trusted technology infrastructure on which we can rely on for so much in our lives

Beta-glucan alters gut microbiota and plasma metabolites in pre-weaning dairy calves

The present study aims to evaluate the alterations in gut microbiome and plasma metabolites of dairy calves with β-glucan (BG) supplementation. Fourteen healthy newborn dairy calves with similar body weight were randomly divided into control (n = 7) and BG (n = 7) groups. All the calves were fed on the basal diet, while calves in the BG group were supplemented with oat BG on d 8 for 14 days. Serum markers, fecal microbiome, and plasma metabolites at d 21 were analyzed. The calves were weaned on d 60 and weighed. The mean weaning weight of the BG group was 4.29 kg heavier than that of the control group. Compared with the control group, the levels of serum globulin, albumin, and superoxide dismutase were increased in the BG group. Oat BG intake increased the gut microbiota richness and decreased the Firmicutes-to-Bacteroidetes ratio. Changes in serum markers were found to be correlated with the plasma metabolites, including sphingosine, trehalose, and 3-methoxy-4-hydroxyphenylglycol sulfate, and gut microbiota such as Ruminococcaceae_NK4A214, Alistipes, and Bacteroides. Overall, these results suggest that the BG promotes growth and health of pre-weaning dairy calves by affecting the interaction between the host and gut microbiota