1,166 research outputs found
Vortex-induced vibration of catenary riser: reduced-order modeling and lock-in analysis using wake oscillator
A new reduced-order model capable of analyzing the vortex-induced vibration of catenary riser in the ocean current has been developed. This semi analytical-numerical approach is versatile and allows for a significant reduction in computational effort for the analysis of fluid-riser interactions. The incoming current flow is assumed to be steady, uniform, unidirectional and perpendicular to the riser plane of initial equilibrium curvatures
Breaking Cosmological Degeneracies in Galaxy Cluster Surveys with a Physical Model of Cluster Structure
Forthcoming large galaxy cluster surveys will yield tight constraints on
cosmological models. It has been shown that in an idealized survey, containing
> 10,000 clusters, statistical errors on dark energy and other cosmological
parameters will be at the percent level. It has also been shown that through
"self-calibration", parameters describing the mass-observable relation and
cosmology can be simultaneously determined, though at a loss in accuracy by
about an order of magnitude. Here we examine the utility of an alternative
approach of self-calibration, in which a parametrized ab-initio physical model
is used to compute cluster structure and the resulting mass-observable
relations. As an example, we use a modified-entropy ("pre-heating") model of
the intracluster medium, with the history and magnitude of entropy injection as
unknown input parameters. Using a Fisher matrix approach, we evaluate the
expected simultaneous statistical errors on cosmological and cluster model
parameters. We study two types of surveys, in which a comparable number of
clusters are identified either through their X-ray emission or through their
integrated Sunyaev-Zel'dovich (SZ) effect. We find that compared to a
phenomenological parametrization of the mass-observable relation, using our
physical model yields significantly tighter constraints in both surveys, and
offers substantially improved synergy when the two surveys are combined. These
results suggest that parametrized physical models of cluster structure will be
useful when extracting cosmological constraints from SZ and X-ray cluster
surveys. (abridged)Comment: 22 pages, 8 figures, accepted to Ap
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER). Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and free RTA enters the cytosol where it inactivates ribosomes. Cytosolic entry requires unfolding of RTA and dislocation across the ER membrane such that it arrives in the cytosol in a vulnerable, nonnative conformation. Clearly, for such a dislocated toxin to become active, it must avoid degradation and fold to a catalytic conformation. Here, we show that, in vitro, Hsc70 prevents aggregation of heat-treated RTA, and that RTA catalytic activity is recovered after chaperone treatment. A combination of pharmacological inhibition and cochaperone expression reveals that, in vivo, cytosolic RTA is scrutinized sequentially by the Hsc70 and Hsp90 cytosolic chaperone machineries, and that its eventual fate is determined by the balance of activities of cochaperones that regulate Hsc70 and Hsp90 functions. Cytotoxic activity follows Hsc70-mediated escape of RTA from an otherwise destructive pathway facilitated by Hsp90. We demonstrate a role for cytosolic chaperones, proteins typically associated with folding nascent proteins, assembling multimolecular protein complexes and degrading cytosolic and stalled, cotranslocational clients, in a toxin triage, in which both toxin folding and degradation are initiated from chaperone-bound states
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER). Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and free RTA enters the cytosol where it inactivates ribosomes. Cytosolic entry requires unfolding of RTA and dislocation across the ER membrane such that it arrives in the cytosol in a vulnerable, nonnative conformation. Clearly, for such a dislocated toxin to become active, it must avoid degradation and fold to a catalytic conformation. Here, we show that, in vitro, Hsc70 prevents aggregation of heat-treated RTA, and that RTA catalytic activity is recovered after chaperone treatment. A combination of pharmacological inhibition and cochaperone expression reveals that, in vivo, cytosolic RTA is scrutinized sequentially by the Hsc70 and Hsp90 cytosolic chaperone machineries, and that its eventual fate is determined by the balance of activities of cochaperones that regulate Hsc70 and Hsp90 functions. Cytotoxic activity follows Hsc70-mediated escape of RTA from an otherwise destructive pathway facilitated by Hsp90. We demonstrate a role for cytosolic chaperones, proteins typically associated with folding nascent proteins, assembling multimolecular protein complexes and degrading cytosolic and stalled, cotranslocational clients, in a toxin triage, in which both toxin folding and degradation are initiated from chaperone-bound states
EXCITATION of COUPLED STELLAR MOTIONS in the GALACTIC DISK by ORBITING SATELLITES
We use a set of high-resolution N-body simulations of the Galactic disk to study its interactions with the population of cosmologically predicted satellites. One simulation illustrates that multiple passages of massive satellites with different velocities through the disk generate a wobble, which has the appearance of rings in face-on projections of the stellar disk. They also produce flares in the outer disk parts and gradually heat the disk through bending waves. A different numerical experiment shows that an individual satellite as massive as the Sagittarius dwarf galaxy passing through the disk will drive coupled horizontal and vertical oscillations of stars in underdense regions with small associated heating. This experiment shows that vertical excursions of stars in these low-density regions can exceed 1 kpc in the Solar neighborhood, resembling the recently locally detected coherent vertical oscillations. They can also induce non-zero vertical streaming motions as large as 10-20 km s-1, which is consistent with recent observations in the Galactic disk. This phenomenon appears as a local ring with modest associated disk heating. © 2016. The American Astronomical Society. All rights reserved
Electron Impact Excitation Cross Sections for Hydrogen-Like Ions
We present cross sections for electron-impact-induced transitions n --> n' in
hydrogen-like ions C 5+, Ne 9+, Al 12+, and Ar 17+. The cross sections are
computed by Coulomb-Born with exchange and normalization (CBE) method for all
transitions with n < n' < 7 and by convergent close-coupling (CCC) method for
transitions with n 2s and 1s
--> 2p are presented as well. The CCC and CBE cross sections agree to better
than 10% with each other and with earlier close-coupling results (available for
transition 1 --> 2 only). Analytical expression for n --> n' cross sections and
semiempirical formulae are discussed.Comment: RevTeX, 5 pages, 13 PostScript figures, submitted to Phys. Rev.
Constraining Cosmic Evolution of Type Ia Supernovae
We present the first large-scale effort of creating composite spectra of
high-redshift type Ia supernovae (SNe Ia) and comparing them to low-redshift
counterparts. Through the ESSENCE project, we have obtained 107 spectra of 88
high-redshift SNe Ia with excellent light-curve information. In addition, we
have obtained 397 spectra of low-redshift SNe through a multiple-decade effort
at Lick and Keck Observatories, and we have used 45 UV spectra obtained by
HST/IUE. The low-redshift spectra act as a control sample when comparing to the
ESSENCE spectra. In all instances, the ESSENCE and Lick composite spectra
appear very similar. The addition of galaxy light to the Lick composite spectra
allows a nearly perfect match of the overall spectral-energy distribution with
the ESSENCE composite spectra, indicating that the high-redshift SNe are more
contaminated with host-galaxy light than their low-redshift counterparts. This
is caused by observing objects at all redshifts with the same slit width, which
corresponds to different projected distances. After correcting for the
galaxy-light contamination, subtle differences in the spectra remain. We have
estimated the systematic errors when using current spectral templates for
K-corrections to be ~0.02 mag. The variance in the composite spectra give an
estimate of the intrinsic variance in low-redshift maximum-light SN spectra of
~3% in the optical and growing toward the UV. The difference between the
maximum light low and high-redshift spectra constrain SN evolution between our
samples to be < 10% in the rest-frame optical.Comment: 22 pages, 22 figures, submitted to ApJ. Composite spectra can be
downloaded from http://astro.berkeley.edu/~rfoley/composite
Molecular Gas in the z=1.2 Ultraluminous Merger GOODS J123634.53+621241.3
We report the detection of CO(2-1) emission from the z=1.2 ultraluminous
infrared galaxy (ULIRG) GOODS J123634.53+621241.3 (also known as the
sub-millimeter galaxy GN26). These observations represent the first discovery
of high-redshift CO emission using the new Combined Array for Research in
Millimeter-Wave Astronomy (CARMA). Of all high-redshift (z>1) galaxies within
the GOODS-North field, this source has the largest far-infrared (FIR) flux
observed in the Spitzer 70um and 160um bands. The CO redshift confirms the
optical identification of the source, and the bright CO(2-1) line suggests the
presence of a large molecular gas reservoir of about 7x10^10 M(sun). The
infrared-to-CO luminosity ratio of L(IR)/L'(CO) = 80+/-30 L(sun) (K Km/s
pc^2)^-1 is slightly smaller than the average ratio found in local ULIRGs and
high-redshift sub-millimeter galaxies. The short star-formation time scale of
about 70 Myr is consistent with a starburst associated with the merger event
and is much shorter than the time scales for spiral galaxies and estimates made
for high-redshift galaxies selected on the basis of their B-z and z-K colors.Comment: Accepted for publication in ApJ Letter
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