Nonminimal state space approach to multivariable ramp metering control of motorway bottlenecks

The paper discusses the automatic control of motorway traffic flows utilising ramp metering, i.e. traffic lights on the on-ramp entrances. A multivariable ramp metering system is developed, based on the nonminimal state space (NMSS) approach to control system design using adaptive proportional-integral-plus, linear quadratic (PIP–LQ) optimal controllers. The controller is evaluated on a nonlinear statistical traffic model (STM) simulation of the Amsterdam motorway ring road near the Coen Tunnel

Electrical capacitance clearanceometer

A hot gas turbine engine capacitive probe clearanceometer is employed to measure the clearance gap or distance between blade tips on a rotor wheel and its confining casing under operating conditions. A braze sealed tip of the probe carries a capacitor electrode which is electrically connected to an electrical inductor within the probe which is inserted into a turbine casing to position its electrode at the inner surface of the casing. Electrical power is supplied through a voltage controlled variable frequency oscillator having a tuned circuit in which the probe is a component. The oscillator signal is modulated by a change in electrical capacitance between the probe electrode and a passing blade tip surface while an automatic feedback correction circuit corrects oscillator signal drift. A change in distance between a blade tip and the probe electrode is a change in capacitance therebetween which frequency modulates the oscillator signal. The modulated oscillator signal which is then processed through a phase detector and related circuitry to provide an electrical signal is proportional to the clearance gap

E-Type Delayed Fluorescence of a Phosphine-Supported Cu_2(μ-NAr_2)_2 Diamond Core: Harvesting Singlet and Triplet Excitons in OLEDs

A highly emissive bis(phosphine)diarylamido dinuclear copper(I) complex (quantum yield = 57%) was shown to exhibit E-type delayed fluorescence by variable temperature emission spectroscopy and photoluminescence decay measurement of doped vapor-deposited films. The lowest energy singlet and triplet excited states were assigned as charge transfer states on the basis of theoretical calculations and the small observed S_1−T_1 energy gap. Vapor-deposited OLEDs doped with the complex in the emissive layer gave a maximum external quantum efficiency of 16.1%, demonstrating that triplet excitons can be harvested very efficiently through the delayed fluorescence channel. The function of the emissive dopant in OLEDs was further probed by several physical methods, including electrically detected EPR, cyclic voltammetry, and photoluminescence in the presence of applied current

Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression

The unfolded protein response (UPR) maintains protein homeostasis by governing the processing capacity of the endoplasmic reticulum (ER) to manage ER client loads; however, key regulators within the UPR remain to be identified. Activation of the UPR sensor PERK (EIFAK3/PEK) results in the phosphorylation of the α subunit of eIF2 (eIF2α-P), which represses translation initiation and reduces influx of newly synthesized proteins into the overloaded ER. As part of this adaptive response, eIF2α-P also induces a feedback mechanism through enhanced transcriptional and translational expression of Gadd34 (Ppp1r15A),which targets type 1 protein phosphatase for dephosphorylation of eIF2α-P to restore protein synthesis. Here we describe a novel mechanism by which Gadd34 expression is regulated through the activity of the zinc finger transcription factor NMP4 (ZNF384, CIZ). NMP4 functions to suppress bone anabolism, and we suggest that this occurs due to decreased protein synthesis of factors involved in bone formation through NMP4-mediated dampening of Gadd34 and c-Myc expression. Loss of Nmp4 resulted in an increase in c-Myc and Gadd34 expression that facilitated enhanced ribosome biogenesis and global protein synthesis. Importantly, protein synthesis was sustained during pharmacological induction of the UPR through a mechanism suggested to involve GADD34-mediated dephosphorylation of eIF2α-P. Sustained protein synthesis sensitized cells to pharmacological induction of the UPR, and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress

Application of response surface techniques to helicopter rotor blade optimization procedure

In multidisciplinary optimization problems, response surface techniques can be used to replace the complex analyses that define the objective function and/or constraints with simple functions, typically polynomials. In this work a response surface is applied to the design optimization of a helicopter rotor blade. In previous work, this problem has been formulated with a multilevel approach. Here, the response surface takes advantage of this decomposition and is used to replace the lower level, a structural optimization of the blade. Problems that were encountered and important considerations in applying the response surface are discussed. Preliminary results are also presented that illustrate the benefits of using the response surface

Leadership Training for Oral Health Professionals: A Call to Action

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153632/1/jddj002203372012762tb05245x.pd

Continuous Melting of a "Partially Pinned" Two-Dimensional Vortex Lattice in a Square Array of Pinning Centers

The structure and equilibrium properties of a two-dimensional system of superconducting vortices in a periodic pinning potential with square symmetry are studied numerically. For a range of the strength of the pinning potential, the low-temperature crystalline state exhibits only one of the two basic periodicities (in the $x$- and $y$-directions) of the pinning potential. This ``partially pinned'' solid undergoes a continuous melting transition to a weakly modulated liquid as the temperature is increased. A spin model, constructed using symmetry arguments, is shown to reproduce the critical behavior at this transition.Comment: 5 pages, 4 figure

Big bottlenecks in cardiovascular tissue engineering.

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges

Automated Inspection Device for Explosive Charge in Shells - AIDECS

Certain defects in the explosive charge of an artillery shell can cause the projectile to explode prematurely in the barrel of the launcher from which it is fired. The sensitivity of the radiographic technique presently used is limited by the large influence of the steel shell casing on the transmitted radiation. A filmless radiometric technique utilizing the basic radiation principle of Compton scattering, which will detect cavities in the explosive filler with minimal interference from the steel casing, has been identified and tested. By scanning the shell with a beam of radiation and observing the Compton scattering through a unique collimating system, it has been possible to detect voids as small as 1/16 inch in cross section. The hardware consists of the source, beam collimator, detector collimator, and a large plastic scintillator detector system. The projectile is inserted into the beam path and moved through a fixed scanning pattern by a mechanical handling system. The scanning sequence is computer contra ll ed and results in a threedimensional data matrix giving a direct representation of density within the projectile. Voids are identified and classified by computer analysis, and shell acceptability decisions are automatically generated. An engineering prototype system is currently being assembled and tested. (A production prototype conceptual design is concurrently under development.) This new technique will replace an existing film radiography inspection procedure and eliminate the need for human interpretation of the defects, while providing more consistent and reliable inspections at lower costs

Molecular Dynamics Simulations of Cyanine Dimers Attached to DNA Holliday Junctions

Dye aggregates and their excitonic properties are of interest for their applications to organic photovoltaics, non-linear optics, and quantum information systems. DNA scaffolding has been shown to be effective at promoting the aggregation of dyes in a controllable manner. Specifically, isolated DNA Holliday junctions have been used to achieve strongly coupled cyanine dye dimers. However, the structural properties of the dimers and the DNA, as well as the role of Holliday junction isomerization are not fully understood. To study the dynamics of cyanine dimers in DNA, molecular dynamics simulations were carried out for adjacent and transverse dimers attached to Holliday junctions in two different isomers. It was found that dyes attached to adjacent strands in the junction exhibit stronger dye-DNA interactions and larger inter-dye separations compared to transversely attached dimers, as well as end-to-end arrangements. Transverse dimers exhibit lower inter-dye separations and more stacked configurations. Furthermore, differences in Holliday junction isomer are analyzed and compared to dye orientations. For transverse dyes exhibiting the smaller inter-dye separations, excitonic couplings were calculated and shown to be in agreement with experiment. Our results suggested that dye attachment locations on DNA Holliday junctions affect dye-DNA interactions, dye dynamics, and resultant dye orientations which can guide the design of DNA-templated cyanine dimers with desired properties