LATE HOLOCENE ACTIVATION HISTORY OF THE STANTON DUNES, NORTHEASTERN NEBRASKA

The Nebraska Sandhills have been an important resource for better understanding dune activation and the nature of prehistoric Great Plains drought events. However, until recently, few studies have focused on documenting the activation histories of smaller dune fields found along the Great Plains\u27 eastern margin. This study focuses on the Stanton dune field, which lies about 145 km east of the Nebraska Sandhills on an alluvial terrace of the Elkhorn River in northeastern Nebraska. Sediments in the Stanton Dunes were dated with optically stimulated luminescence (OSL) to determine when these dunes were active. The ages indicate three activation periods that cluster into the following time periods: ~5,800-3,800, 960-630, and 510-410 years ago. The ages that fall into our two older clusters closely agree with dune activation records from the Nebraska Sandhills and other major central Great Plains dune fields, suggesting that these large-scale droughts also impacted eastern Nebraska. However, our youngest cluster of ages occurs at a time when the Nebraska Sandhills were thought to be largely inactive, suggesting that the Stanton Dunes may have been activated by a locally important drought event that had a more limited impact on dunes found to the west

Groundwater level assessment and prediction in the Nebraska Sand Hills using LIDAR-derived lake water level

The spatial variability of groundwater levels is often inferred from sparsely located hydraulic head observations in wells. The spatial correlation structure derived from sparse observations is associated with uncertainties that spread to estimates at unsampled locations. In areas where surface water represents the nearby groundwater level, remote sensing techniques can estimate and increase the number of hydraulic head measurements. This research uses light detection and ranging (LIDAR) to estimate lake surface water level to characterize the groundwater level in the Nebraska Sand Hills (NSH), an area with few observation wells. The LIDAR derived lake groundwater level accuracy was within 40 cm mean square error (MSE) of the nearest observation wells. The lake groundwater level estimates were used to predict the groundwater level at unsampled locations using universal kriging (UK) and kriging with an external drift (KED). The results indicate unbiased estimates of groundwater level in the NSH. UK showed the influence of regional trends in groundwater level while KED revealed the local variation present in the groundwater level. A 10-fold cross-validation demonstrated KED with better mean squared error (ME) [–0.003, 0.007], root mean square error (RMSE) [2.39, 4.46], residual prediction deviation (RPD) [1.32, 0.71] and mean squared deviation ratio (MSDR) [1.01, 1.49] than UK. The research highlights that the lake groundwater level provides an accurate and cost-effective approach to measure and monitor the subtle changes in groundwater level in the NSH. This methodology can be applied to other locations where surface water bodies represent the water level of the unconfined aquifer and the results can aid in groundwater management and modeling

Polarized Broad-Line Emission from Low-Luminosity Active Galactic Nuclei

In order to determine whether unified models of active galactic nuclei apply to low-luminosity objects, we have undertaken a spectropolarimetric survey of of LINERs and Seyfert nuclei at the Keck Observatory. The 14 objects observed have a median H-alpha luminosity of 8x10^{39} erg/s, well below the typical value of ~10^{41} erg/s for Markarian Seyfert nuclei. Polarized broad H-alpha emission is detected in three LINERs: NGC 315, NGC 1052, and NGC 4261. Each of these is an elliptical galaxy with a double-sided radio jet, and the emission-line polarization in each case is oriented roughly perpendicular to the jet axis, as expected for the obscuring torus model. NGC 4261 and NGC 315 are known to contain dusty circumnuclear disks, which may be the outer extensions of the obscuring tori. The detection of polarized broad-line emission suggests that these objects are nearby, low-luminosity analogs of obscured quasars residing in narrow-line radio galaxies. The nuclear continuum of the low-luminosity Seyfert 1 galaxy NGC 4395 is polarized at p = 0.67%, possibly the result of an electron scattering region near the nucleus. Continuum polarization is detected in other objects, with a median level of p = 0.36% over 5100-6100 A, but in most cases this is likely to be the result of transmission through foreground dust. The lack of significant broad-line polarization in most type 1 LINERs is consistent with the hypothesis that we view the broad-line regions of these objects directly, rather than in scattered light.Comment: 28 pages, including 3 tables and 16 figures. Uses the emulateapj latex style file. Accepted for publication in The Astrophysical Journa

The low-temperature energy calibration system for the CUORE bolometer array

The CUORE experiment will search for neutrinoless double beta decay (0nDBD) of 130Te using an array of 988 TeO_2 bolometers operated at 10 mK in the Laboratori Nazionali del Gran Sasso (Italy). The detector is housed in a large cryogen-free cryostat cooled by pulse tubes and a high-power dilution refrigerator. The TeO_2 bolometers measure the event energies, and a precise and reliable energy calibration is critical for the successful identification of candidate 0nDBD and background events. The detector calibration system under development is based on the insertion of 12 gamma-sources that are able to move under their own weight through a set of guide tubes that route them from deployment boxes on the 300K flange down into position in the detector region inside the cryostat. The CUORE experiment poses stringent requirements on the maximum heat load on the cryostat, material radiopurity, contamination risk and the ability to fully retract the sources during normal data taking. Together with the integration into a unique cryostat, this requires careful design and unconventional solutions. We present the design, challenges, and expected performance of this low-temperature energy calibration system.Comment: To be published in the proceedings of the 13th International Workshop on Low Temperature Detectors (LTD), Stanford, CA, July 20-24, 200

Image Sharing Technologies and Reduction of Imaging Utilization: A Systematic Review and Meta-analysis

INTRODUCTION: Image sharing technologies may reduce unneeded imaging by improving provider access to imaging information. A systematic review and meta-analysis were conducted to summarize the impact of image sharing technologies on patient imaging utilization. METHODS: Quantitative evaluations of the effects of PACS, regional image exchange networks, interoperable electronic heath records, tools for importing physical media, and health information exchange systems on utilization were identified through a systematic review of the published and gray English-language literature (2004-2014). Outcomes, standard effect sizes (ESs), settings, technology, populations, and risk of bias were abstracted from each study. The impact of image sharing technologies was summarized with random-effects meta-analysis and meta-regression models. RESULTS: A total of 17 articles were included in the review, with a total of 42 different studies. Image sharing technology was associated with a significant decrease in repeat imaging (pooled effect size [ES] = -0.17; 95% confidence interval [CI] = [-0.25, -0.09]; P < .001). However, image sharing technology was associated with a significant increase in any imaging utilization (pooled ES = 0.20; 95% CI = [0.07, 0.32]; P = .002). For all outcomes combined, image sharing technology was not associated with utilization. Most studies were at risk for bias. CONCLUSIONS: Image sharing technology was associated with reductions in repeat and unnecessary imaging, in both the overall literature and the most-rigorous studies. Stronger evidence is needed to further explore the role of specific technologies and their potential impact on various modalities, patient populations, and settings

Usage of query-based health information exchange after event notifications

ABSTRACT Objectives: This study sought to quantify the association between event notifications and subsequent querybased health information exchange (HIE) use among end users of three different community health information organizations. Materials and Methods: Using system-log data merged with user characteristics, regression-adjusted estimates were used to describe the association between event notifications and subsequent query-based HIE usage. Results: Approximately 5% of event notifications were associated with query-based HIE usage within 30 days. In adjusted models, odds of query-based HIE usage following an event notification were higher for older patients and for alerts triggered by a discharge event. Query-based HIE usage was more common among specialty clinics and Federally Qualified Health Centers than primary care organizations. Discussion and Conclusion: In this novel combination of data, 1 in 20 event notifications resulted in subsequent query-based HIE usage. Results from this study suggest that event notifications and query-based HIE can be applied together to address clinical and population health use cases

Nebraska Statewide Groundwater-Level Monitoring Report 2021

This report is a synthesis of groundwater-level monitoring programs in Nebraska. It is a continuation of the series of annual reports and maps produced by the Conservation and Survey Division (CSD) of the University of Nebraska in cooperation with the U.S. Geological Survey (USGS) since the 1950s. Groundwater-level monitoring began in Nebraska in 1930 in an effort to survey the state’s groundwater resources and to observe changes in its availability on a continuing basis. The CSD and USGS cooperatively developed, maintained, and operated an observation-well network throughout the state. These two agencies were responsible for collecting and archiving this information, and for making it available to the citizens

Differences in transcription between free-living and CO_2-activated third-stage larvae of Haemonchus contortus

Background: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once ingested with herbage by the host, undergoes an exsheathment process that marks the transition from the free-living (L3) to the parasitic (xL3) stage. This study explored changes in gene transcription associated with this transition and predicted, based on comparative analysis, functional roles for key transcripts in the metabolic pathways linked to larval development. Results: Totals of 101,305 (L3) and 105,553 (xL3) expressed sequence tags (ESTs) were determined using 454 sequencing technology, and then assembled and annotated; the most abundant transcripts encoded transthyretin-like, calcium-binding EF-hand, NAD(P)-binding and nucleotide-binding proteins as well as homologues of Ancylostoma-secreted proteins (ASPs). Using an in silico-subtractive analysis, 560 and 685 sequences were shown to be uniquely represented in the L3 and xL3 stages, respectively; the transcripts encoded ribosomal proteins, collagens and elongation factors (in L3), and mainly peptidases and other enzymes of amino acid catabolism (in xL3). Caenorhabditis elegans orthologues of transcripts that were uniquely transcribed in each L3 and xL3 were predicted to interact with a total of 535 other genes, all of which were involved in embryonic development. Conclusion: The present study indicated that some key transcriptional alterations taking place during the transition from the L3 to the xL3 stage of H. contortus involve genes predicted to be linked to the development of neuronal tissue (L3 and xL3), formation of the cuticle (L3) and digestion of host haemoglobin (xL3). Future efforts using next-generation sequencing and bioinformatic technologies should provide the efficiency and depth of coverage required for the determination of the complete transcriptomes of different developmental stages and/or tissues of H. contortus as well as the genome of this important parasitic nematode. Such advances should lead to a significantly improved understanding of the molecular biology of H. contortus and, from an applied perspective, to novel methods of intervention

Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets

The blood fluke Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease (NTD) that affects more than 110 million people. Treating this disease by targeted or mass administration with a single chemical, praziquantel, carries the risk that drug resistance will develop in this pathogen. Therefore, there is an imperative to search for new drug targets in S. haematobium and other schistosomes. In this regard, protein kinases have potential, given their essential roles in biological processes and as targets for drugs already approved by the US Food and Drug Administration (FDA) for use in humans. In this context, we defined here the kinome of S. haematobium using a refined bioinformatic pipeline. We classified, curated and annotated predicted kinases, and assessed the developmental transcription profiles of kinase genes. Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind to them using an integrated bioinformatic pipeline. Most kinases of S. haematobium are very similar to those of its congener, S. mansoni, offering the prospect of designing chemicals that kill both species. Overall, this study provides a global insight into the kinome of S. haematobium and should assist the repurposing or discovery of drugs against schistosomiasis