Neoirietriol

The title compound {systematic name: (1R,4S,4aS,7R,8aR)-4-bromo-7-[(1S,3R)-3-bromo-1,2,2-trimethyl­cyclo­pent­yl]-1,4a-dimethyl­deca­hydro­naphthalene-1,7,8a-triol}, C20H34Br2O3, is a neoirieane-type bromo­diterpenoid isolated from Laurencia yonaguniensis Masuda et Abe, species inedita. The absolute stereochemistry was established as (1S,4R,5R,7R,10S,11S,14R). The structure displays inter- and intra­molecular O—H⋯O hydrogen bonding

Mobile Robot Self Localization based on Multi-Antenna-RFID Reader and IC Tag Textile

This paper presents a self-localization system using multiple RFID reader antennas and High-Frequency RFID-tag textile floor for an indoor autonomous mobile robot. Conventional self-localization systems often use vision sensors and/or laser range finders and an environment model. It is difficult to estimate the exact global location if the environment has number of places that have similar shape boundaries or small number of landmarks to localize. It tends to take a long time to recover the self-localization estimation if it goes wrong at once. Vision sensors work hard in dark lighting condition. Laser range finder often fails to detect distance to a transparent wall. In addition, the self-localization becomes unstable if obstacles occlude landmarks that are important to estimate position of the robot. Door opening and closing condition affects the self- localization performance. Self-localization system based on reading RFID-tags on floor is robust against lighting condition, obstacles, furniture and doors conditions in the environment. Even if the arrangement of the obstacles or furniture in the environment is changed, it is not necessary to update the map for the self-localization. It can localize itself immediately and is free from well-known kidnapped robot problem because the RFID-tags give global po- sition information. Conventional self-localization systems based on reading RFID-tags on floor often use only one RFID reader antenna and have difficulty of orientation estimation. We have developed a self-localization system using multiple RFID reader antennas and High-Frequency RFID-tag textile floor for an indoor autonomous mobile robot. Experimental results show the validity of the proposed methods.2013 IEEE Workshop on Advanced Robotics and its Social Impacts (ARSO) Shibaura Institute of Technology, Tokyo, JAPAN November 7-9, 201

Japanese subpopulation analysis of MONARCH 2: phase 3 study of abemaciclib plus fulvestrant for treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer that progressed on endocrine therapy

BACKGROUND: This was a Japanese subpopulation analysis of MONARCH 2, a double-blind, randomized, placebo-controlled, phase 3 study of abemaciclib plus fulvestrant in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer (ABC). METHODS: Eligible women had progressed on (neo)adjuvant endocrine therapy (ET),  ≤ 12 months from end of adjuvant ET, or on first-line ET for ABC, and had not received chemotherapy for ABC. Patients were randomized 2:1 to receive abemaciclib or placebo plus fulvestrant. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), pharmacokinetics (PK), health-related quality of life (HRQoL), and safety. RESULTS: In Japan, 95 patients were randomized (abemaciclib, n = 64; placebo, n = 31). At final PFS analysis (February 14, 2017), median PFS was 21.2 and 14.3 months, respectively, in the abemaciclib and placebo groups (hazard ratio: 0.672; 95% confidence interval: 0.380-1.189). Abemaciclib had a higher objective response rate (37.5%) than placebo (12.9%). PK and safety profiles for Japanese patients were consistent with those of the overall population, without clinically meaningful differences across most HRQoL dimensions evaluated. The most frequent adverse events in the abemaciclib versus placebo groups were diarrhea (95.2 versus 25.8%), neutropenia (79.4 versus 0%), and leukopenia (66.7 versus 0%). At a second data cutoff (June 20, 2019), median OS was not reached with abemaciclib and 47.3 months with placebo (hazard ratio: 0.755; 95% confidence interval: 0.390-1.463). CONCLUSIONS: Results of the Japanese subpopulation were consistent with the improved clinical outcomes and manageable safety profile observed in the overall population. CLINICAL TRIAL REGISTRATION: NCT02107703; U.S. National Library of Medicine: https://clinicaltrials.gov/ct2/show/NCT02107703

Male Breast Cancer Originating in an Accessory Mammary Gland in the Axilla: A Case Report

Carcinoma of an accessory mammary gland is an extremely rare tumor. A 61-year-old male patient presented with a hard mass measuring 85 mm × 51 mm in the left axilla. Incisional biopsy histopathologically showed an adenocarcinoma compatible with breast carcinoma originating in an accessory mammary gland. Systemic examinations revealed no evidence of malignant or occult primary lesion in the bilateral mammary glands or in other organs. Neoadjuvant chemotherapy was performed for the locally advanced axillary tumor and reduced the tumor to 55 mm in size, and, then, he could undergo complete resection with a negative surgical margin in combination with reconstructive surgery to fill the resulting skin defect with a local flap of the latissimus dorsi muscle. The patient has presented with no metastatic lesion in four years since the operation. This unusual case shows that neoadjuvant chemotherapy is an effective and tolerated therapy for advanced accessory breast cancer in the axilla

In Situ Synchrotron X-ray Analysis: Application of High-Pressure Sliding Process to Ti Allotropic Transformation

In this study, severe plastic deformation through high-pressure sliding (HPS) was applied for in situ high-energy X-ray diffraction analysis at SPring-8 in JASRI (Japan Synchrotron Radiation Research Institute). Allotropic transformation of pure Ti was examined in terms of temperatures, pressures and imposed strain using a miniaturized HPS facility. The true pressure applied on the sample was estimated from the peak shift. Peak broadening due to local variation of pressure was reduced using white X-rays. The phase transformation from α phase to ω phase occurred at a pressure of ∼4.5 GPa. Straining by the HPS processing was effective to promote the transformation to the ω phase and to maintain the ω phase even at ambient pressure. The reverse transformation from ω phase to α phase occurred at a temperature of ∼110°C under ambient pressure, while under higher pressure as ∼4 GPa, the ω phase remained stable even at ∼170°C covered in this study. It was suggested that the reverse transformation from the ω phase to the α phase is controlled by thermal energy