3,772 research outputs found
Quantum codes give counterexamples to the unique pre-image conjecture of the N-representability problem
It is well known that the ground state energy of many-particle Hamiltonians
involving only 2-body interactions can be obtained using constrained
optimizations over density matrices which arise from reducing an N-particle
state. While determining which 2-particle density matrices are "N-
representable" is a computationally hard problem, all known extreme
N-representable 2-particle reduced density matrices arise from a unique
N-particle pre-image, satisfying a conjecture established in 1972. We present
explicit counterexamples to this conjecture through giving Hamiltonians with
2-body interactions which have degenerate ground states that cannot be
distinguished by any 2-body operator. We relate the existence of such
counterexamples to quantum error correction codes and topologically ordered
spin systems.Comment: 4 pages, 1 figur
Descendants of the first stars: the distinct chemical signature of second generation stars
Extremely metal-poor (EMP) stars in the Milky Way (MW) allow us to infer the
properties of their progenitors by comparing their chemical composition to the
metal yields of the first supernovae. This method is most powerful when applied
to mono-enriched stars, i.e. stars that formed from gas that was enriched by
only one previous supernova. We present a novel diagnostic to identify this
subclass of EMP stars. We model the first generations of star formation
semi-analytically, based on dark matter halo merger trees that yield MW-like
halos at the present day. Radiative and chemical feedback are included
self-consistently and we trace all elements up to zinc. Mono-enriched stars
account for only of second generation stars in our fiducial model
and we provide an analytical formula for this probability. We also present a
novel analytical diagnostic to identify mono-enriched stars, based on the metal
yields of the first supernovae. This new diagnostic allows us to derive our
main results independently from the specific assumptions made regarding Pop III
star formation, and we apply it to a set of observed EMP stars to demonstrate
its strengths and limitations. Our results may provide selection criteria for
current and future surveys and therefore contribute to a deeper understanding
of EMP stars and their progenitors.Comment: 18 pages, 20 figures, published in MNRA
Cancer's sweet tooth for serine
Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken centerstage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets of human melanoma and breast cancers to have high levels of phosphoglycerate dehydrogenase (PHGDH), a key enzyme for serine biosynthesis, and these cancer cells are dependent on PHGDH for their growth and survival. Tumors may thus harbor distinct metabolic alterations to support their malignancy, and targeting enzymes such as PHGDH might prove a viable therapeutic strategy in this scenario
Evolution of the Schr\"odinger--Newton system for a self--gravitating scalar field
Using numerical techniques, we study the collapse of a scalar field
configuration in the Newtonian limit of the spherically symmetric
Einstein--Klein--Gordon (EKG) system, which results in the so called
Schr\"odinger--Newton (SN) set of equations. We present the numerical code
developed to evolve the SN system and topics related, like equilibrium
configurations and boundary conditions. Also, we analyze the evolution of
different initial configurations and the physical quantities associated to
them. In particular, we readdress the issue of the gravitational cooling
mechanism for Newtonian systems and find that all systems settle down onto a
0--node equilibrium configuration.Comment: RevTex file, 19 pages, 26 eps figures. Minor changes, matches version
to appear in PR
Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress
We previously demonstrated that CBF activity is needed for cell proliferation and early embryonic development. To examine the in vivo function of CBF in differentiated hepatocytes, we conditionally deleted CBF-B in hepatocytes after birth. Deletion of CBF-B resulted in progressive liver injury and severe hepatocellular degeneration 4 weeks after birth. Electron microscopic examination demonstrated pleiotropic changes of hepatocytes including enlarged cell and nuclear size, intracellular lipid deposition, disorganized endoplasmic reticulum, and mitochondrial abnormalities. Gene expression analyses showed that deletion of CBF-B activated expression of specific endoplasmic reticulum (ER) stress-regulated genes. Inactivation of CBF-B also inhibited expression of C/EBP alpha, an important transcription factor controlling various metabolic processes in adult hepatocytes. Altogether, our study reveals for the first time that CBF is a key transcription factor controlling ER function and metabolic processes in mature hepatocytes
Quantum Simulation of Tunneling in Small Systems
A number of quantum algorithms have been performed on small quantum
computers; these include Shor's prime factorization algorithm, error
correction, Grover's search algorithm and a number of analog and digital
quantum simulations. Because of the number of gates and qubits necessary,
however, digital quantum particle simulations remain untested. A contributing
factor to the system size required is the number of ancillary qubits needed to
implement matrix exponentials of the potential operator. Here, we show that a
set of tunneling problems may be investigated with no ancillary qubits and a
cost of one single-qubit operator per time step for the potential evolution. We
show that physically interesting simulations of tunneling using 2 qubits (i.e.
on 4 lattice point grids) may be performed with 40 single and two-qubit gates.
Approximately 70 to 140 gates are needed to see interesting tunneling dynamics
in three-qubit (8 lattice point) simulations.Comment: 4 pages, 2 figure
Subaru Hyper Suprime-Cam Survey for An Optical Counterpart of GW170817
We perform a -band survey for an optical counterpart of a binary neutron
star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted
transient search covers deg corresponding to the credible
region of GW170817 and reaches the completeness magnitude of mag
on average. As a result, we find 60 candidates of extragalactic transients,
including J-GEM17btc (a.k.a. SSS17a/DLT17ck). While J-GEM17btc is associated
with NGC 4993 that is firmly located inside the 3D skymap of GW170817, the
other 59 candidates do not have distance information in the GLADE v2 catalog or
NASA/IPAC Extragalactic Database (NED). Among 59 candidates, 58 are located at
the center of extended objects in the Pan-STARRS1 catalog, while one candidate
has an offset. We present location, -band apparent magnitude, and time
variability of the candidates and evaluate the probabilities that they are
located inside of the 3D skymap of GW170817. The probability for J-GEM17btc is
being much higher than those for the other 59 candidates
(). Furthermore, the possibility, that at
least one of the other 59 candidates is located within the 3D skymap, is only
. Therefore, we conclude that J-GEM17btc is the most-likely and
distinguished candidate as the optical counterpart of GW170817.Comment: 14 pages, 9 figures. Accepted for publication in PASJ (Publications
of the Astronomical Society of Japan
Boson Stars: Alternatives to primordial black holes?
The present surge for the astrophysical relevance of boson stars stems from
the speculative possibility that these compact objects could provide a
considerable fraction of the non-baryonic part of dark matter within the halo
of galaxies. For a very light `universal' axion of effective string models,
their total gravitational mass will be in the most likely range of \sim 0.5
M_\odot of MACHOs. According to this framework, gravitational microlensing is
indirectly ``weighing" the axion mass, resulting in \sim 10^{-10} eV/c^2. This
conclusion is not changing much, if we use a dilaton type self-interaction for
the bosons. Moreover, we review their formation, rotation and stability as
likely candidates of astrophysical importance.Comment: 14 pages, uses REVTeX, 1 postscript figur
Effects of some salts on H2O as probed by a thermodynamic signature of glycerol: towards understanding the Hofmeister effects (VII)
- …