67 research outputs found

    Inhibition and Adjective Learning in Bilingual and Monolingual Children

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    The ability to control attention – by inhibiting pre-potent, yet no longer relevant information – is an essential skill in all of human learning, and increasing evidence suggests that this ability is enhanced in language learning environments in which the learner is managing and using more than one language. One question waiting to be addressed is whether such efficient attentional control plays a role in word learning. That is, children who must manage two languages also must manage to learn two languages and the advantages of more efficient attentional control may benefit aspects of language learning within each language. This study compared bilingual and monolingual children’s performances in an artificial word-learning task and in a non-linguistic task that measures attention control. Three-year-old monolingual and bilingual children with similar vocabulary development participated in these tasks. The results replicate earlier work showing advanced attentional control among bilingual children and suggest that this better attentional control may also benefit better performance in novel adjective learning. The findings provide the first direct evidence of a relation between performances in an artificial word-learning task and in an attentional control task. We discuss this finding with respect to the general relevance of attentional control for lexical learning in all children and with respect to current views of bilingual children’s word learning

    Gaze is not Enough: Computational Analysis of Infant’s Head Movement Measures the Developing Response to Social Interaction

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    Schillingmann L, Burling JM, Yoshida H, Nagai Y. Gaze is not Enough: Computational Analysis of Infant’s Head Movement Measures the Developing Response to Social Interaction. Presented at the 37th Annual Meeting of the Cognitive Science Society

    How do Infants Coordinate Head and Gaze?: Computational Analysis of Infant’s First Person View in Social Interactions

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    Schillingmann L, Burling JM, Yoshida H, Nagai Y. How do Infants Coordinate Head and Gaze?: Computational Analysis of Infant’s First Person View in Social Interactions. Presented at the Biennial Meeting of the SRCD, Philadelphia

    Phylogenetic analyses of Chilomastix and Retortamonas species using in vitro excysted flagellates

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    Abstract In vitro excystation of cysts of microscopically identified Chilomastix mesnili and Retortamonas sp. isolated from Japanese macaques and Retortamonas sp. isolated from small Indian mongooses could be induced using an established protocol for Giardia intestinalis and subsequently by culturing with H2S-rich Robinson’s medium supplemented with Desulfovibrio desulfuricans. Excystation usually began 2 h after incubation in Robinson’s medium. DNA was isolated from excysted flagellates after 4 h of incubation or from cultured excysted flagellates. Phylogenetic analysis based on their 18S rRNA genes revealed that two isolates of C. mesnili from Japanese macaques belonged to the same cluster as a C. mesnili isolate from humans, whereas a mammalian Retortamonas sp. isolate from a small Indian mongoose belonged to the same cluster as that of an amphibian Retortamonas spp. isolate from a ‘poison arrow frog’ [sequence identity to AF439347 (94.9%)]. These results suggest that the sequence homology of the 18S rRNA gene of the two C. mesnili isolates from Japanese macaques was similar to that of humans, in addition to the morphological similarity, and Retortamonas sp. infection of the amphibian type in the small Indian mongoose highlighted the possibility of the effect of host feeding habitats

    A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis

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    京大開発の薬剤「KUS121」の変形性膝関節症への効果を確認 --外傷性変形性関節症の治療薬として臨床応用へ--. 京都大学プレスリリース. 2020-12-17.Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage chondrocyte death is a promising strategy to mitigate the development of PTOA. Namely, we examined efficacies of Kyoto University Substance (KUS) 121, a valosin-containing protein modulator, for PTOA as well as its therapeutic mechanisms. In vivo, in a rat PTOA model by cyclic compressive loading, intra-articular treatments of KUS121 significantly improved the modified Mankin scores and reduced damaged-cartilage volumes, as compared to vehicle treatment. Moreover, KUS121 markedly reduced the numbers of TUNEL-, CHOP-, MMP-13-, and ADAMTS-5-positive chondrocytes in the damaged knees. In vitro, KUS121 rescued human articular chondrocytes from tunicamycin-induced cell death, in both monolayer culture and cartilage explants. It also significantly downregulated the protein or gene expression of ER stress markers, proinflammatory cytokines, and extracellular-matrix-degrading enzymes induced by tunicamycin or IL-1β. Collectively, these results demonstrated that KUS121 protected chondrocytes from cell death through the inhibition of excessive ER stress. Therefore, KUS121 would be a new, promising therapeutic agent with a protective effect on the progression of PTOA
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