<i>In Situ</i> Construction of a Polymer Coating Layer on the LiNi_0.8Co_0.1Mn_0.1O₂ Cathode for High-Performance Lithium-Ion Batteries

Lithium-ion batteries (LIBs) are known for their high energy density but exhibit poor cyclic stability and safety risks due to side reactions between the electrode and electrolyte. To address these issues, a novel approach involving construction of a polymer coating layer (PCL) via in situ self-polymerization using 2,2,3,4,4,4-hexafluorobutyl methacrylate (HFBM) as an electrolyte additive on the cathode is proposed. The PCL endows the electrolyte with a high onset oxidation potential (4.78 V) and lithium-ion transference number (0.52). The uniform and robust in situ constructed PCL can effectively inhibit the severe irreversible side reactions and suppress harmful reactions, thus providing a protective barrier against degradation. The resulting Li||LiNi0.8Co0.1Mn0.1O2 batteries exhibit an improved discharge capacity retention of 80% at 1C over 100 cycles. These results demonstrate that the in situ self-polymerization strategy holds promising potential for enhancing LIB performance and long-term stability, especially when high-voltage cathode materials are used

Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis

Abstract Background Observational studies have explored the association of psychiatric disorders and the risk of brain cancers. However, the causal effect of specific mental illness on glioma remains elusive due to the lack of solid evidence. Methods We performed a two-sample bidirectional Mendelian randomization (MR) analysis to explore the causal relationships between 5 common psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorder, and panic disorder) and glioma. Summary statistics for psychiatric disorders and glioma were extracted from Psychiatric Genomics Consortium (PGC) and 8 genome-wide association study (GWAS) datasets respectively. We calculated the MR estimates for odds ratio of glioma associated with each psychiatric disorder by using inverse-variance weighting (IVW) method. Sensitivity analyses such as weighted median estimator, MR-Egger and MR-PRESSO were leveraged to assess the strength of causal inference. Results A total of 30,657 participants of European ancestry were included in this study. After correction for multiple testing, we found that genetically predicted schizophrenia was associated with a statistically significant increase in odds of non-glioblastoma multiforme (non-GBM) (OR = 1.13, 95% CI: 1.03–1.23, P = 0.0096). There is little evidence for the causal relationships between the other 4 psychiatric disorders with the risk of glioma. Conclusions In this MR analysis, we revealed an increased risk of non-GBM glioma in individuals with schizophrenia, which gives an insight into the etiology of glioma

5V-Class Electrolytes Based on Fluorinated Solvents for Li-Ion Batteries with Excellent Cyclability

A novel electrochemically compatible, high-voltage, and nonflammable electrolyte has been prepared based on a fluorinated ether with no flash point, that is, 1,1,1,3,3,3-hexafluoroisopropyl methyl ether (HFPM). Our experimental results demonstrate that this F-electrolyte is not only totally nonflammable in fire burning tests, but it also exhibits a remarkably high anodic stability of at least 5.5V (vs. Li+/Li). In particular, this F-electrolyte has good compatibility with graphite anodes. Mesocarbon microbeads/LiNi0.5Mn1.5O4 18650 batteries made with this F-electrolyte display an excellent cycling stability with 82% capacity retention after 200 cycles at a high cutoff voltage of 4.9V, confirming their potential as high-voltage lithium-ion batteries with enhanced safety and longevity

Additional file 1 of Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis

Supplementary Table 1 Summary of 8 glioma GWAS dataset

Survival Benefits of Radiotherapy and Surgery in Lung Cancer Brain Metastases with Poor Prognosis Factors

Background: Radiotherapy and surgery are the standard local treatments for lung cancer brain metastases (BMs). However, limited studies focused on the effects of radiotherapy and surgery in lung cancer BMs with poor prognosis factors. Methods: We retrospectively analyzed 714 patients with lung cancer BMs. Analyses of overall survival (OS) and risk factors for OS were assessed by the log-rank test and Cox proportional hazard model. Results: Age ≥ 65 years, a Karnofsky Performance Scale (KPS) score ≤ 70, anaplastic large-cell lymphoma kinase (ALK)/epidermal growth factor receptor (EGFR) wild type, and extracranial metastases were related to poor prognosis. Patients were stratified according to these poor prognosis factors. In patients with the ALK/EGFR wild type, whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), and surgery improved the OS of patients. WBRT and SRS were the independent protective factors for OS. In patients with extracranial metastases, patients who received WBRT plus SRS or WBRT alone had longer OS than those who did not receive radiotherapy. WBRT plus SRS and WBRT were the independent protective factors for OS. Conclusions: Radiotherapy and surgery are associated with improved survival for lung cancer BMs with the ALK/EGFR wild type. Radiotherapy is associated with improved survival in lung cancer BMs with extracranial metastases

Study of energetic particle physics with advanced ECEI system on the HL-2A tokamak

Understanding the physics of energetic particles (EP) is crucial for the burning plasmas in next generation fusion devices such as ITER. In this work, three types of internal kink modes (a saturated internal kink mode (SK), a resonant internal kink mode (RK), and a double e-fishbone) excited by energetic particles in the low density discharges during ECRH/ECCD heating have been studied by the newly developed 24(poloidal) × 16(radial) = 384 channel ECEI system on the HL-2A tokamak. The SK and RK rotate in the electron diamagnetic direction poloidally and are destabilized by the energetic trapped electrons. The SK is destabilized in the case of qmin > 1, while the RK is destabilized in the case of qmin < 1. The double e-fishbone, which has two m/n = 1/1 modes propagating in the opposite directions poloidally, has been observed during plasma current ramp-up with counter-ECCD. Strong thermal transfer and mode coupling between the two m/n = 1/1 modes have been studied