Financial transactions tax : panacea, threat, or damp squib ?

Attempts to raise a significant percentage of gross domestic product in revenue from a broad-based financial transactions tax are likely to fail both by raising much less revenue than expected and by generating far-reaching changes in economic behavior. Although the side-effects would include a sizable restructuring of financial sector activity, this would not occur in ways corrective of the particular forms of financial overtrading that were most conspicuous in contributing to the crisis.Debt Markets,Emerging Markets,Taxation&Subsidies,Banks&Banking Reform,Economic Theory&Research

Patients' Perceptions and Treatment Effectiveness

An extensive literature relating patients’ expectations to treatment outcomes has not addressed the determinants of these expectations. We argue that treatment history is part of a reference point that influences patients’ expectations of how effective further treatment might be, thus influencing whether to proceed with additional treatment or not. We hypothesize that those patients with unsuccessful prior treatments have diminished expected improvement from subsequent treatments. Prospect theory provides a theoretical foundation for reference frame effects, and the model is tested with data on patients diagnosed with idiopathic intracranial hypertension. Our results support the reference frame hypothesis.Prospect Theory, Treatment Outcomes, Treatment History, Misclassification, Monotone Rank Estimator

Autonomous Light Management in Flexible Photoelectrochromic Films Integrating High Performance Silicon Solar Microcells

Commercial smart window technologies for dynamic light and heat management in building and automotive environments traditionally rely on electrochromic (EC) materials powered by an external source. This design complicates building-scale installation requirements and substantially increases costs for applications in retrofit construction. Self-powered photoelectrochromic (PEC) windows are an intuitive alternative wherein a photovoltaic (PV) material is used to power the electrochromic device, which modulates the transmission of the incident solar flux. The PV component in this application must be sufficiently transparent and produce enough power to efficiently modulate the EC device transmission. Here, we propose Si solar microcells (μ-cells) that are i) small enough to be visually transparent to the eye, and ii) thin enough to enable flexible PEC devices. Visual transparency is achieved when Si μ-cells are arranged in high pitch (i.e. low-integration density) form factors while maintaining the advantages of a single-crystalline PV material (i.e., long lifetime and high performance). Additionally, the thin dimensions of these Si μ-cells enable fabrication on flexible substrates to realize these flexible PEC devices. The current work demonstrates this concept using WO₃ as the EC material and V₂O₅ as the ion storage layer, where each component is fabricated via sol-gel methods that afford improved prospects for scalability and tunability in comparison to thermal evaporation methods. The EC devices display fast switching times, as low as 8 seconds, with a modulation in transmission as high as 33%. Integration with two Si μ-cells in series (affording a 1.12 V output) demonstrates an integrated PEC module design with switching times of less than 3 minutes, and a modulation in transmission of 32% with an unprecedented EC:PV areal ratio

Tidal Limits to Planetary Habitability

The habitable zones of main sequence stars have traditionally been defined as the range of orbits that intercept the appropriate amount of stellar flux to permit surface water on a planet. Terrestrial exoplanets discovered to orbit M stars in these zones, which are close-in due to decreased stellar luminosity, may also undergo significant tidal heating. Tidal heating may span a wide range for terrestrial exoplanets and may significantly affect conditions near the surface. For example, if heating rates on an exoplanet are near or greater than that on Io (where tides drive volcanism that resurface the planet at least every 1 Myr) and produce similar surface conditions, then the development of life seems unlikely. On the other hand, if the tidal heating rate is less than the minimum to initiate plate tectonics, then CO_2 may not be recycled through subduction, leading to a runaway greenhouse that sterilizes the planet. These two cases represent potential boundaries to habitability and are presented along with the range of the traditional habitable zone for main sequence, low-mass stars. We propose a revised habitable zone that incorporates both stellar insolation and tidal heating. We apply these criteria to GJ 581 d and find that it is in the traditional habitable zone, but its tidal heating alone may be insufficient for plate tectonics.Comment: 13 pages, 2 figures, accepted to ApJ Letters. A version with full resolution images is available at http://www.astro.washington.edu/users/rory/publications/bjgr09.pd

Approach to Qualification for Electron Beam Powder Bed Fusion in Ti-6Al-4V

Recent developments in additive manufacturing (AM) show promise for using AM manufactured components in a production setting. However, a crucial step for mass producing AM components is to certify these parts for use. One common method for certifying parts is to manufacture tensile coupons alongside any parts. These coupons are characterized and the results are related to the parts. This causes many researchers to focus on the process-material interactions while neglecting build setup. Another issue related to certification of AM parts is the lack of knowledge in the software calculations for a given process. Original equipment manufacturers (OEM), such as Arcam AB for electron beam powder bed fusion (E-PBF), need secrecy in their software to ensure their scan strategy is protected. Therefore, this practice provides researchers little information or confidence about changes made in process parameters. To provide insight into these areas of variation, the current work can be broken into two parts – (i) understanding how changes in selected process parameters can influence non-selected parameters and (ii) determining the effectiveness of current qualification methods for the E-PBF process.To better understand process parameters, changes in selected process parameters were simulated and compared with the Arcam provided parameter set. Results of these simulations show that speed function variable is only a function of melting time while modifications to the contour passes and surface temperature result in changes to the heat balance. Variations in the heat balance change the cooling rate of as-fabricated material, which causes microstructural evolution in titanium alloys. Preliminary results show that modifying the surface temperature for specific regions can be used to control microstructure.To better understand how build setup can influence parts in a build, build setup variables such as part melt order, build volume, and cross-sectional melt area were modified between two builds. Results of these changes show that performance in test coupons cannot be applied to performance in the other parts since changes in build setup influence each part differently. The current work provide challenges to applying traditional qualification methods to AM fabricated components in hopes that a process-based certification path can be achieved

Reliability of Striatal [11C]Raclopride Binding in Smokers Wearing Transdermal Nicotine Patches

PURPOSE: In studies where [(11)C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. METHODS: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. RESULTS: Across the striatum, test-retest variability was 7.63 ± 5.88; percent change in binding potential was 1.11 ± 9.83; and the intraclass correlation coefficient was 0.91 (p < 0.0001). CONCLUSION: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine

Identification and comparison of Mycobacterium avium isolates from patients and foods using polymerase chain reaction

The genus Mycobacterium is commonly associated with diseases such as leprosy, tuberculosis and other pulmonary infections. Mycobacterium avium is increasingly identified as a cause of disseminated disease in AIDS patients. A need for a better understanding of possible sources and routes of transmission of this organism is necessary. This study fircCalifornia State University, Northridge. Department of Biology.Includes bibliographical references (leaves 25-30

Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics

Background Striatal dopamine (DA) has been implicated in alcohol use disorders, but it is still unclear whether or not alcohol can induce dopamine release in social drinkers. Furthermore, no data exist on dopamine responses to alcohol in dependent drinkers. We sought to characterize the DA responses to alcohol intoxication in moderately large samples of social drinkers (SD) and nontreatment-seeking alcoholics (NTS). Methods Twenty-four SD and twenty-one NTS received two [11C]raclopride (RAC) PET scans; one at rest, and one during an intravenous alcohol infusion, with a prescribed ascent to a target breath alcohol concentration (BrAC), at which it was then “clamped.” The alcohol clamp was started 5 min after scan start, with a linear increase in BrAC over 15 min to the target of 80 mg%, the legal threshold for intoxication. Target BrAC was maintained for 30 min. Voxel-wise binding potential (BPND) was estimated with MRTM2. Results IV EtOH induced significant increases in DA in the right ventral striatum in NTS, but not SD. No decreases in DA were observed in either group. Conclusions Alcohol intoxication results in distinct anatomic profiles of DA responses in SD and NTS, suggesting that in NTS, the striatal DA system may process effects of alcohol intoxication differently than in SD

Identical probes on different high-density oligonucleotide microarrays can produce different measurements of gene expression

BACKGROUND: There are many potential sources of variability in a microarray experiment. Variation can arise from many aspects of the collection and processing of samples for gene expression analysis. Oligonucleotide-based arrays are thought to minimize one source of variability as identical oligonucleotides are expected to recognize the same transcripts during hybridization. RESULTS: We demonstrate that although the probes on the U133A GeneChip arrays are identical in sequence to probes designed for the U133 Plus 2.0 arrays the values obtained from an experimental hybridization can be quite different. Nearly half of the probesets in common between the two array types can produce slightly different values from the same sample. Nearly 70% of the individual probes in these probesets produced array specific differences. CONCLUSION: The context of the probe may also contribute some bias to the final measured value of gene expression. At a minimum, this should add an extra level of caution when considering the direct comparison of experiments performed in two microarray formats. More importantly, this suggests that it may not be possible to know which value is the most accurate representation of a biological sample when comparing two formats

Regional to Global Assessments of Phytoplankton Dynamics From The SeaWiFS Mission

Photosynthetic production of organic matter by microscopic oceanic phytoplankton fuels ocean ecosystems and contributes roughly half of the Earth's net primary production. For 13 years, the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) mission provided the first consistent, synoptic observations of global ocean ecosystems. Changes in the surface chlorophyll concentration, the primary biological property retrieved from SeaWiFS, have traditionally been used as a metric for phytoplankton abundance and its distribution largely reflects patterns in vertical nutrient transport. On regional to global scales, chlorophyll concentrations covary with sea surface temperature (SST) because SST changes reflect light and nutrient conditions. However, the oceanmay be too complex to be well characterized using a single index such as the chlorophyll concentration. A semi-analytical bio-optical algorithm is used to help interpret regional to global SeaWiFS chlorophyll observations from using three independent, well-validated ocean color data products; the chlorophyll a concentration, absorption by CDM and particulate backscattering. First, we show that observed long-term, global-scale trends in standard chlorophyll retrievals are likely compromised by coincident changes in CDM. Second, we partition the chlorophyll signal into a component due to phytoplankton biomass changes and a component caused by physiological adjustments in intracellular chlorophyll concentrations to changes in mixed layer light levels. We show that biomass changes dominate chlorophyll signals for the high latitude seas and where persistent vertical upwelling is known to occur, while physiological processes dominate chlorophyll variability over much of the tropical and subtropical oceans. The SeaWiFS data set demonstrates complexity in the interpretation of changes in regional to global phytoplankton distributions and illustrates limitations for the assessment of phytoplankton dynamics using chlorophyll retrievals alone