Application of poly(3,4-ethylenedioxythiophene)/manganese dioxide composite-modified electrode for sensitive electrochemical detection of luteolin

In this work, the electrochemical determination of luteolin using poly(3,4-ethylenedioxythiophene)/manganese dioxide nanocomposite modified glassy carbon electrode (PEDOT/MnO₂/GCE) is reported. PEDOT/MnO₂ nanocomposite has been proposed via a simple two-step deposition approach. Electrochemical results revealed that PEDOT/MnO₂ showed enhanced electrocatalytic performance toward luteolin, which might be attributed to good conductivity and accelerated electron transfer of PEDOT and good catalytic effect of MnO₂. Experimental conditions, including pH values and scan rates were optimized. In optimal conditions, a good linear relationship was found between oxidation peak currents and the concentration of luteolin in 5.0 nM-7.0 μM range. The detection limit was calculated to be 1.8 nM at a signal-to-noise ratio of 3. Finally, the applicability for luteolin determination in real samples was successfully demonstrated.10 page(s